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PF-9366

PF-9366 Structure
PF-9366 structure
CAS No.
72882-78-1
Chemical Name:
PF-9366
Synonyms
CS-2703;PF-9366;PF 9366 NEW;PF-9366; PF 9366; PF9366;72882-78-1;PF-9366,inhibit,PF9366,PF 9366,Inhibitor;[1,2,4]Triazolo[4,3-a]quinoline-1-ethanamine, 7-chloro-N,N-dimethyl-5-phenyl-;2-(7-Chloro-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine
CBNumber:
CB13375661
Molecular Formula:
C20H19ClN4
Molecular Weight:
350.84
MDL Number:
MFCD31630724
MOL File:
72882-78-1.mol
Last updated:2023-09-20 16:43:00
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PF-9366 Properties

Melting point 182-183.5 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Density 1.25±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in DMSO (up to 20 mg/ml).
pka 8.75±0.28(Predicted)
form solid
color Beige
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

PF-9366 price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 30782 PF-9366 72882-78-1 5mg $81 2024-03-01 Buy
Cayman Chemical 30782 PF-9366 72882-78-1 25mg $317 2024-03-01 Buy
Cayman Chemical 30782 PF-9366 72882-78-1 10mg $152 2024-03-01 Buy
TRC P294108 PF-9366 72882-78-1 10mg $825 2021-12-16 Buy
AK Scientific 9179CT CID12612431 72882-78-1 50mg $640 2021-12-16 Buy
Product number Packaging Price Buy
30782 5mg $81 Buy
30782 25mg $317 Buy
30782 10mg $152 Buy
P294108 10mg $825 Buy
9179CT 50mg $640 Buy

PF-9366 Chemical Properties,Uses,Production

Description

PF-9366 (72882-78-1) is an allosteric inhibitor (IC50?= 420 nM) of methionine adenosyltransferase 2A (Mat2A), the primary enzyme responsible for extrahepatic synthesis of S-adenosyl-L-methionine (SAM).1?It inhibited cellular SAM production in H520 lung and Huh-7 liver cancer cells with IC50’s of 1.2 μM and 225 nM respectively.

Uses

PF-9366 is a novel inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform.

References

1) Quinlan?et al. (2017),?Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A; Nat. Chem. Biol.,?13?785

PF-9366 synthesis

51-80-9
75-36-5
36916-18-4
72882-78-1
Synthesis of PF-9366 from N,N,N',N'-TETRAMETHYLDIAMINOMETHANE and Acetyl chloride and [1,2,4]Triazolo[4,3-a]quinoline, 7-chloro-1-methyl-5-phenyl-

PF-9366 Preparation Products And Raw materials

Raw materials

[1,2,4]Triazolo[4,3-a]quinoline, 7-chloro-1-methyl-5-phenyl- Acetyl chloride N,N,N',N'-TETRAMETHYLDIAMINOMETHANE

Preparation Products

PF-9366 Suppliers

Global( 56)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
Chemia Biotechnology（Shanghai） Co., Ltd 		+8613816753574 info@chemia-pharm.com CHINA 311 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3136 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998 757984502@qq.com China 892 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4121 55
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Career Henan Chemica Co 		58
Chemia Biotechnology（Shanghai） Co., Ltd 		58
InvivoChem 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		58
LEAPCHEM CO., LTD. 		58
Aladdin Scientific 		58
Shanghai Lollane Biological Technology Co.,Ltd. 55

PF-9366 Spectrum

PF-9366(72882-78-1)1HNMR

72882-78-1(PF-9366)Related Search:

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1of4

PF-9366 CS-2703 PF-9366; PF 9366; PF9366;72882-78-1 PF 9366 NEW [1,2,4]Triazolo[4,3-a]quinoline-1-ethanamine, 7-chloro-N,N-dimethyl-5-phenyl- 2-(7-Chloro-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine PF-9366,inhibit,PF9366,PF 9366,Inhibitor 72882-78-1 API