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1-(2,6-Dimethylphenoxy)-2-propanamine

1-(2,6-Dimethylphenoxy)-2-propanamine
1-(2,6-Dimethylphenoxy)-2-propanamine structure
CAS No.
31828-71-4
Chemical Name:
1-(2,6-Dimethylphenoxy)-2-propanamine
Synonyms
C07220;MEXILETIN;Mexilitine;Mexiletine;Mexilitine R;dl-Mexiletine;(RS)-Mexiletine;1-Methyl-2-(2,6-xylyloxy)ethylamine;1-methyl-2-(2,6-xylyloxy)-ethylamin;1-(2,6-dimethylphenoxy)-2-propanamin
CBNumber:
CB9497353
Molecular Formula:
C11H17NO
Formula Weight:
179.25878
MOL File:
31828-71-4.mol

1-(2,6-Dimethylphenoxy)-2-propanamine Properties

Melting point:
203-205 °C
Boiling point:
271.5±28.0 °C(Predicted)
Density 
0.979±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
ethanol: 50 mg/mL
pka
pKa 9.14± 0.01(H2O,t =25±0.2,I=0.01(NaCl))(Approximate)
form 
powder
color 
white
CAS DataBase Reference
31828-71-4(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
1U511HHV4Z
NIST Chemistry Reference
Mexiletine(31828-71-4)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36
RIDADR  3249
WGK Germany  3
RTECS  KR9300000
HazardClass  6.1(b)
PackingGroup  III

1-(2,6-Dimethylphenoxy)-2-propanamine Chemical Properties,Uses,Production

Uses

Cardiac depressant (anti-arrhythmic).

Definition

ChEBI: An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.

brand name

Mexitil (Boehringer Ingelheim).

Clinical Use

Mexiletine (Mexitil) is an antiarrhythmic agent with pharmacological and antiarrhythmic properties similar to those of lidocaine and tocainide. Like tocainide,mexiletine is available for oral administration.
Mexiletine is useful as an antiarrhythmic agent in the management of patients with either acute or chronic ventricular arrhythmias.While it is not at present an indication for use, there is interest in using mexiletine to treat the congenital long QT syndrome when an abnormality in the SCN5A gene (LQTS 3) has been found.

Side effects

A very narrow therapeutic window limits mexiletine use. The first signs of toxicity manifest as fine tremor of the hands, followed by dizziness and blurred vision. Hypotension, sinus bradycardia, and widening of the QRS complex have been noted as the most common unwanted cardiovascular effects of IV mexiletine. The side effects of oral maintenance therapy include reversible upper gastrointestinal distress, tremor, lightheadedness, and coordination difficulties. These effects generally are not serious and can be reduced by downward dose adjustment or administering the drug with meals. Cardiovascular adverse effects, which are less common, include palpitations, chest pain, and angina or anginalike pain.

Drug interactions

An upward adjustment in dose may be required when mexiletine is administered with phenytoin or rifampin, since these drugs stimulate the hepatic metabolism of mexiletine, reducing its plasma concentration.

Precautions

Mexiletine is contraindicated in the presence of cardiogenic shock or preexisting second- or third-degree heart block in the absence of a cardiac pacemaker. Caution must be exercised in administration of the drug to patients with sinus node dysfunction or disturbances of intraventricular conduction.

1-(2,6-Dimethylphenoxy)-2-propanamine Preparation Products And Raw materials

Raw materials

Preparation Products


1-(2,6-Dimethylphenoxy)-2-propanamine Suppliers

Global( 44)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2754 55
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571 sales@zhonglanindustry.com CHINA 4895 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63728 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 20534 58
Mainchem Co., Ltd. +86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32444 55
Hangzhou Yuhao Chemical Technology Co., Ltd 0571-82693216
+86-571-82880190 info@yuhaochemical.com China 9406 52
Beijing HuaMeiHuLiBiological Chemical 010-56205725
010-65763397 waley188@sohu.com China 12341 58
Hangzhou J&H Chemical Co., Ltd. 0571-87396432-
0571-87396431 sales@jhechem.com; China 13913 53
LABTER PHARMATECH(BEIJING) CO.,LTD 18310155299 010-56330744
010-56330744 sales@labter.com.cn China 22702 55

View Lastest Price from 1-(2,6-Dimethylphenoxy)-2-propanamine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-05-11 Mexiletine
31828-71-4
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd

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