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Diethylstilbestrol Produkt Beschreibung

Diethylstilbestrol Struktur
56-53-1
CAS-Nr.
56-53-1
Bezeichnung:
Diethylstilbestrol
Englisch Name:
Diethylstilbestrol
Synonyma:
DES;Stil;CSM1;CSM2;-PVT;ALPHA;Bufon;Cyren;Desma;Sibol
CBNumber:
CB9751457
Summenformel:
C18H20O2
Molgewicht:
268.35
MOL-Datei:
56-53-1.mol

Diethylstilbestrol Eigenschaften

Schmelzpunkt:
170-172 °C(lit.)
Siedepunkt:
351.51°C (rough estimate)
Dichte
1.1096 (rough estimate)
Brechungsindex
1.4800 (estimate)
storage temp. 
0-6°C
Löslichkeit
methanol: 0.1 g/mL, clear, faintly yellow
pka
pKa 9.02(H2O t=25 I=0.025) (Uncertain)
Aggregatzustand
Crystalline Powder
Farbe
White to almost white
Wasserlöslichkeit
PRACTICALLY INSOLUBLE
Merck 
13,3155
BRN 
2056095
Stabilität:
Isomerizes rapidly in Benzene, Chloroform, and Ether. Keep Shielded from light.
CAS Datenbank
56-53-1(CAS DataBase Reference)
NIST chemische Informationen
Diethylstilbesterol(56-53-1)
EPA chemische Informationen
Phenol, 4,4'-[(1E)-1,2-diethyl- 1,2-ethenediyl]bis-(56-53-1)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T,N
R-Sätze: 45-61-36/37/38-51/53-40
S-Sätze: 53-36/37/39-45-60-61-36/37
RIDADR  UN 3077 9/PG 3
WGK Germany  3
RTECS-Nr. WJ5600000
10
HazardClass  6.1(b)
PackingGroup  III
HS Code  29072990
Giftige Stoffe Daten 56-53-1(Hazardous Substances Data)
Toxizität LD50 oral in rat: > 3gm/kg
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
H350 Kann Krebs verursachen. Karzinogenität Kategorie 1A Achtung
H360 Kann die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung
H410 Sehr giftig für Wasserorganismen mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 1 Warnung P273, P391, P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P261 Einatmen von Staub vermeiden.
P273 Freisetzung in die Umwelt vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Diethylstilbestrol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R45:Kann Krebs erzeugen.
R61:Kann das Kind im Mutterleib schädigen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R40:Verdacht auf krebserzeugende Wirkung.

S-Sätze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.

Chemische Eigenschaften

White Solid

Verwenden

A synthetic, nonsteroidal estrogen. Recomended solvents are DMSO, DMF and ethanol, even in these solvents do not store in solution for any prolonged period of time.

Trademarks

Stilbestrol (Tablicaps); Stilbetin (Bristol-Myers Squibb);Distilbene;Oestro-gynedron;Stilphostrol.

Weltgesundheitsorganisation (WHO)

Diethylstilbestrol, a synthetic estrogen which is a stilbene derivative, was introduced into obstetric practice in the late 1940s and subsequently widely used for the treatment of threatened abortion. This use was later shown to be associated with an increased risk of vaginal cancer in the offspring which resulted in restrictive regulatory action in several countries. Diethylstilbestrol and other stilbenes remain available in many countries, however, for the treatment of certain hormone-dependent neoplasms including carcinoma of the prostate and postmenopausal breast cancer. (Reference: (WHODI) WHO Drug Information, 77.1, 16, 1977)

Allgemeine Beschreibung

At first glance, it might be surprising that synthetic nonsteroidal molecules such as diethylstilbestrol (DES) could have the same activity as estradiol or other estrogens. DES can be viewed, however, as a form of estradiol with rings B and C open and a six-carbon ring D. The activity of DES analogs was explained in 1946. It was proposed that the distance between the two DES phenol OH groups was the same as the 3-OH to 17-OH distance of estradiol; therefore, they could both fit the same receptor. Medicinal chemists have shown the OH-to-OH distance to be actually 12.1 ? in DES and 10.9 ? in estradiol. In aqueous solution, however, estradiol has two water molecules that are hydrogen bonded to the 17-OH. If one of the two water molecules is included in the distance measurement, there is a perfect fit with the two OH groups of DES. This suggests that water may have an important role for estradiol in its receptor site.
It is now generally accepted that the estrogens must have a phenolic moiety for binding, but some investigators propose that the receptor may be flexible enough to accommodate varying distances between the two key hydroxyls. This point about estrogens needing a phenolic ring for high-affinity binding to the ER is critical. Steroids with a phenolic A ring and related phenolic compounds lack high-affinity binding to the other steroid hormone receptors.

Allgemeine Beschreibung

Odorless tasteless white crystalline powder.

Air & Water Reaktionen

Insoluble in water.

Reaktivität anzeigen

Diethylstilbestrol is incompatible with strong oxidizing agents, strong bases, acid chlorides and acid anhydrides .

Brandgefahr

Flash point data for Diethylstilbestrol are not available; however, Diethylstilbestrol is probably combustible.

Sicherheitsprofil

Confirmed carcinogen producing skin, liver, and lung tumors in exposed humans as well as uterine and other reproductive system tumors in the female offspring of exposed women. Experimental carcinogenic, neoplas tigenic, tumorigenic, and teratogenic data. A transplacental carcinogen. A human teratogen by many routes. Poison by intraperitoneal and subcutaneous routes. It causes glandular system effects by sktn contact. Human reproductive effects by ingestion: abnormalspermatogenesis; changes in testes, epididymis, and sperm duct; menstrual cycle changes or disorders; changes in female ferulity; unspecified maternal effects; developmental abnormalities of the fetal urogenital system; germ cell effects in offspring; and delayed effects in newborn. Implicated in male impotence and enlargement of male breasts. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and fumes. See also ETHINYL ESTRADIOL.

Carcinogenicity

Diethylstilbestrol is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans.

Diethylstilbestrol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Diethylstilbestrol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 216)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21671 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32447 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 535 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 892 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58

56-53-1(Diethylstilbestrol)Verwandte Suche:


  • -Amino-3-(phosphonomethyl)-2-quinoxalinepropanoic Acid
  • Dibromonicotinate
  • Methyl 4,​
  • -Phenyl-2-piperidinemethanol (Mixture)
  • -Methyl-N-(phenylmethyl)benzenepropanamine
  • -(Bromomethyl)-2,4-dichlorobenzenemethanol
  • -Methyl-N-(phenylmethyl)benzenepropanamine-d3
  • Amino-hexanoic Acid Phenylmethyl Ester
  • -Amino-2-Benzofuranacetic Acid Methyl Ester
  • -dimethoxychalcone
  • -Ethyl-4,4'
  • -Truxillin
  • Amino-hexanoic Acid Phenylmethyl Ester 4,4'
  • alanyl-D-alanine
  • Aminocycloheptanecar​
  • boxylic Acid
  • -(Methylenecyclopropyl)glycine (Mixture of Diastereomers)
  • 4-bis(2-phenylethyl)-1,4-piperazinediacetic Acid 1,4-Diethyl Ester
  • 4S,2S,5S)-2,5-Dimethyl-3,6-dioxo-&alpha
  • Difluorocyclobutanol
  • -Methyl-5-indanethylamine-D6 Hydrochloride
  • -(phenylmethyl)benzenehexanoic Acid
  • -[[(1,1-Dimethylethoxy)carbonyl]amino]-&gamma
  • -hydroxy-&alpha
  • R)-&delta
  • R,&delta
  • 1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl-d4]-&alpha
  • D-(+)-Trehalose, Dihydrate (&alpha
  • -D-glucopyranoside, D-Trehalose)
  • -Trehalose, Mycose, &alpha
  • d3)​
  • -Hexylcinnamaldehyde, stabilized
  • R-Brivaracetam-d7
  • -Diphenylprolinol Hydrochloride
  • Pentafluoropropanoic Acid-13C
  • (3S)-1-[2-(3-Ethenyl-4-hydroxyphenyl)ethyl]-&alpha
  • Aminopyridine-​
  • piperidinamine-d3
  • -[[(1S)-1-Carboxyethyl]amino]benzenebutanoic Acid
  • -[[(2-Amino-4-thiazolyl)(hydroxyimino)acetyl]amino]-1,2,5,7-tetrahydro-5-methyl-7-oxo-4H-Furo[3,4-d][1,3]thiazine-2-acetic Acid Sodium Salt||(Mixture of Diastereomers)
  • 4-[(2-Vinyl]-1-enthyne)-&alpha
  • -Methyl-N-[3-[4-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethan|amine|
  • -(1-demethylethyl)-Verapamil Hydrochloride
  • (3R)-&alpha
  • -[(Acetyloxy)imino]-2-(formylamino)-4-thiazoleacetic Acid (Mixture)
  • -[(Acetyloxy)imino]-2-amino-4-thiazoleacetic Acid + (&alpha
  • -(methoxymethylene)benzeneacetic Acid Methyl Ester
  • E)-2-[(6-Chloro-4-pyrimidinyl)oxy]-&alpha
  • -Bromostyrene (~90%, ~1% Hydroquinone as stabilizer)
  • -Amino-4-octylbenzenebutanoic Acid
  • -Methyl-1-pentyl-1H-indole-3-ethanamine (2Z)-2-Butenedioate
  • methyl-1H-pyrrolo[3,4-b]pyridine Hydrochloride
  • diiodo-benzenepropanoic Acid
  • dinitrophenoxy)​
  • Leucine-​
  • -[(Acetyloxy)imino]-2-(formylamino)-4-thiazoleacetic Acid-13C,15N2
  • Tetrachlorododecane
  • azepin-​
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