MANZAMINE A
- CAS No.
- 104196-68-1
- Chemical Name:
- MANZAMINE A
- Synonyms
- MANZAMINE A;Keramamine A;1,13-Etheno-4,21a-methano-1H-azocino[1',2':1,5]pyrrolo[3,2-e]azacyclopentadecin-13(13aH)-ol, 2,3,5,6,7,8,11,12,15,16,17,18,20a,21-tetradecahydro-24-(9H-pyrido[3,4-b]indol-1-yl)-, (1R,4S,9Z,13S,13aR,20aR,21aR)-
- CBNumber:
- CB9838727
- Molecular Formula:
- C36H44N4O
- Molecular Weight:
- 548.76
- MDL Number:
- MFCD00883806
- MOL File:
- 104196-68-1.mol
- MSDS File:
- SDS
Melting point | >240(disassembly) |
---|---|
Boiling point | 756.6±60.0 °C(Predicted) |
Density | 1.26±0.1 g/cm3(Predicted) |
storage temp. | -20° |
solubility | Soluble in DMSO (up to 25 mg/ml). |
pka | 13.58±0.40(Predicted) |
form | Off white to yellow solid. |
color | Off-White to Pale Yellow |
optical activity | +5020 (CHCl3) |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
NFPA 704 |
|
MANZAMINE A price More Price(7)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 21444 | Manzamine A ≥98% | 104196-68-1 | 500μg | $129 | 2024-03-01 | Buy |
Cayman Chemical | 21444 | Manzamine A ≥98% | 104196-68-1 | 1mg | $232 | 2024-03-01 | Buy |
TRC | M186003 | ManzamineA | 104196-68-1 | 2.5mg | $795 | 2021-12-16 | Buy |
Biorbyt Ltd | orb546096 | Manzamine A >98% | 104196-68-1 | 5mg | $1281.8 | 2021-12-16 | Buy |
Biorbyt Ltd | orb546096 | Manzamine A >98% | 104196-68-1 | 1mg | $365.5 | 2021-12-16 | Buy |
MANZAMINE A Chemical Properties,Uses,Production
Description
Manzamine A (104196-68-1) inhibits vacuolar ATPases and inhibits autophagy in pancreatic cancer cells1. Suppresses atherosclerosis?in vivo2. Manzamine A displays neuritogenic activity3?and suppresses tau hyperphosphorylation in human neuroblastoma cell lines4.
Uses
Manzamine A is a β-Carboline alkaloid with anti-inflammatory.
Definition
ChEBI: An alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).
storage
+4°C
References
1) Kallifatidis?et al. (2013),?The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells; Mar. Drugs,?11?3500 2) Eguchi?et al. (2013),?Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo; Bioorg. Med. Chem.,?21?3831 3) Zhang?et al. (2008),?Neuritogenic activity-guided isolation of a free base form manzamine A from a marine sponge, Acanthostrongylophora aff. Igens (Thiele, 1899); Chem. Pharm. Bull.,?56?866 4) Hamann?et al. (2007),?Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer’s disease; J. Nat. Prod.,?70 139
MANZAMINE A Preparation Products And Raw materials
Raw materials
Preparation Products
MANZAMINE A Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
Chengdu Push Bio-Technology Co., Ltd. | 028-85370565-229 18080489829 | 3004654993@qq.com | China | 9266 | 60 |
Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-0755-85201366 18938635012 | sales@regentsciences.com | China | 9303 | 58 |
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
Chengdu Alfa Biotechnology Co.,Ltd. | 028-028-85142057 19983342022 | 3005359975@qq.com | China | 2002 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |