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エノキサシン

エノキサシン 化学構造式
74011-58-8
CAS番号.
74011-58-8
化学名:
エノキサシン
别名:
エノキサシン;エノキサシン 1.5 水和物
英語化学名:
Enoxacin
英語别名:
ENX;ci919;enoram;Abenox;Enoxen;Enoxor;Humark;at-2266;flumark;Gyramid
CBNumber:
CB2403021
化学式:
C15H17FN4O3
分子量:
320.32
MOL File:
74011-58-8.mol

エノキサシン 物理性質

融点 :
220-224 C
比重(密度) :
1.2931 (estimate)
貯蔵温度 :
2-8°C
水溶解度 :
50 mg/ml in 1 M NaOHSlightly soluble in sodium hydroxide, dimethyl sulfoxide, chloroform and methanol. Insoluble in water.
CAS データベース:
74011-58-8(CAS DataBase Reference)

安全性情報

主な危険性  Xi
Rフレーズ  36/37/38
Sフレーズ  26-36/37
WGK Germany  2
RTECS 番号 QN2800000
HSコード  29335995
毒性 LD50 in male, female mice, male, female rats (mg/kg): 327, 391, 236, 294 i.v.; 1237, 1320, >2000, >2000 s.c.; all >5000 orally (Senda)

エノキサシン 価格 もっと(12)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01FLC358124
1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
74011-58-8 5g ¥57400 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01FLC358124
1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
74011-58-8 25g ¥172300 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCE557600 エノキサシン
Enoxacin
74011-58-8 10g ¥77500 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01LKTE5358 エノキサシン
Enoxacin
74011-58-8 500mg ¥8100 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCE557600 エノキサシン
Enoxacin
74011-58-8 500mg ¥11300 2018-12-26 購入

エノキサシン MSDS


Enoxacin

エノキサシン 化学特性,用途語,生産方法

外観

白色~うすい黄褐色, 結晶~粉末

溶解性

酢酸に溶けやすく、メタノールに溶けにくく、クロロホルムに極めて溶けにくく、水、エタノール(95)及びジエチルエーテルにほとんど溶けない。

用途

DNA ジャイレースを阻害し、 抗菌作用を示します。

効能

抗菌薬, 核酸合成阻害薬

特長

(Wako BioWindow 2015.7/No.138, p36)

使用上の注意

不活性ガス封入

説明

Enoxacin is a broad spectrum, quinolone-class, antibacterial agent closely related structurally to nalidixic acid. The serum half-life (6.2 hrs.) and urinary recovery (70%) are considerably greater than for other newer agents of this class, such as norfloxacin (10) and earlier mentioned ciprofloxacin.

化学的特性

Off-White to Pale Yellow Solid

Originator

Dainippon (Japan)

使用

A flurorquinolone antibacterial used to treat urinary tract infections and gonorrhea.

使用

A fluororquinolone antibacterial used to treat urinary tract infections and gonorrhea.

定義

ChEBI: A 1,8-naphthyridine derivative that is 1,4-dihydro-1,8-naphthyridine with an ethyl group at the 1 position, a carboxy group at the 3-position, an oxo sustituent at the 4-position, a fluoro substituent at the 5-position and a piperazin-1-yl group at the 7 p sition. An antibacterial, it is used in the treatment of urinary-tract infections and gonorrhoea.

brand name

Penetrex (Sanofi Aventis);FLUMARK.

応用例(製薬)

A 1,8 naphthyridone derivative available as an oral drug. It exhibits good activity in vitro against many species of Enterobacteriaceae. It is inactive against Ps. aeruginosa, Serratia, Citrobacter, Acinetobacter and Mycobacterium spp., as well as anaerobes, chlamydiae and ureaplasmas.
It is well absorbed and widely distributed when given orally. Absorption is not significantly affected by food, but ranitidine, sucralfate and some antacids or mineral supplements may interfere with absorption. After repeated doses of 400 mg every 12 h for 14 days, mean peak plasma levels reach 3.5–4.5 mg/L, a steady state being achieved in 3–4 days.

臨床応用

1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8- naphthyridine-3-carboxylic acid (Penetrex) is a quinolone with broad-spectrum antibacterial activity that is used primarily for the treatment of urinary tract infections and sexually transmitted diseases. Enoxacin has been approved for the treatment of uncomplicated gonococcal urethritis and has also been shown to be effective in chancroid caused by Haemophilus ducreyi. A single 400-mg dose is used for these indications. Enoxacin is also approved for the treatment of acute (uncomplicated) and chronic (complicated) urinary tract infections. Enoxacin is well absorbed following oral administration. Oral bioavailability approaches 98%. Concentrations of the drug in the kidneys, prostate, cervix, fallopian tubes, and myometrium typically exceed those in the plasma. More than 50% of the unchanged drug is excreted in the urine. Metabolism, largely catalyzed by cytochrome P450 enzymes in the liver, accounts for 15% to 20% of the orally administered dose of enoxacin. The relatively short elimination half-life of enoxacin dictates twice-a-day dosing for the treatment of urinary tract infections. Some cytochrome P450 isozymes, such as CYP 1A2, are inhibited by enoxacin, resulting in potentially important interactions with other drugs. For example, enoxacin has been reported to decrease theophylline clearance, causing increased plasma levels and increased toxicity. Enoxacin forms insoluble chelates with divalent metal ions present in antacids and hematinics, which reduce its oral bioavailability.

エノキサシン 上流と下流の製品情報

原材料

準備製品


エノキサシン 生産企業

Global( 188)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21726 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23976 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58

74011-58-8(エノキサシン)キーワード:


  • 74011-58-8
  • 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-car
  • at-2266
  • bactidan
  • ci919
  • comprecin
  • enoram
  • Enoxacine
  • Gluconate Norfloxacin
  • Enoxacin(Penetrex)
  • Enofloxacin
  • Enofloxacine
  • Enoksetin
  • NSC 629661
  • Enoxacin API
  • Enoxacin 1.5-Hydrate
  • 1,8-naphthyridine-3-carboxylicacid,1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-pi
  • Enoxacin Solution, 100ppm
  • Enoxacin solution,1000ppm
  • 1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-7-[1-PIPERAZINYL]-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID
  • ENOXACIN
  • Enoxacin (Flumark)
  • flumark
  • pd107779
  • Enoxacin (Patent-No-Supply)
  • ENX
  • Flumeork
  • Gyramid
  • Enoxacin (DMF)
  • 1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-7-(1-PIPERAZINYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID (ENOXACIN)
  • Abenox
  • エノキサシン
  • エノキサシン 1.5 水和物
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