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カルバミン酸エチル

カルバミン酸エチル 化学構造式
51-79-6
CAS番号.
51-79-6
化学名:
カルバミン酸エチル
别名:
カルバミン酸エチル;プラカルバミン;エチルウレタン;エチルカルバマート;エスタン-5703;カルバミド酸エチル;アミノぎ酸エチル;ウレタン;ウレタン(カルバミン酸エチル);エチル=カルバマート;カルバミン酸エチル ウレタン;カルバミド酸エチル STANDARD;カルバミン酸エチル標準品;ウレタン STANDARD;ウレタン, 結晶;ウレタン Standard, 5.0 mg/mL in MeOH;カルバミド酸エチル Standard, 100 µg/mL in MeOH
英語化学名:
Urethane
英語别名:
x41;X 41;a11032;nsc746;Uretan;NSC 746;nsc-746;uretano;Urethan;rethane
CBNumber:
CB4368670
化学式:
C3H7NO2
分子量:
89.09
MOL File:
51-79-6.mol

カルバミン酸エチル 物理性質

融点 :
48-50 °C(lit.)
沸点 :
182-184 °C(lit.)
比重(密度) :
1.10
蒸気密度:
3.07 (vs air)
蒸気圧:
10 mm Hg ( 77.8 °C)
屈折率 :
1.4144
闪点 :
198 °F
貯蔵温度 :
Room temperature.
溶解性:
slightly soluble
酸解離定数(Pka):
13.58±0.50(Predicted)
外見 :
Crystals or Crystalline Powder
色:
White
PH:
pH(50g/l, 25℃) : 5.0~7.0
水溶解度 :
slightly soluble
Merck :
14,9874
BRN :
635810
安定性::
Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
CAS データベース:
51-79-6(CAS DataBase Reference)
NISTの化学物質情報:
Urethane(51-79-6)
EPAの化学物質情報:
Urethane (51-79-6)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T
Rフレーズ  45-22
Sフレーズ  53-45-99
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
RTECS 番号 FA8400000
TSCA  Yes
HSコード  29241990
有毒物質データの 51-79-6(Hazardous Substances Data)
毒性 MLD i.p. in mice: 2.1-2.2 g/kg (Franklin)
化審法 (2)-1712
安衛法 57,57-2
PRTR法 第二種指定化学物質
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H340 遺伝性疾患のおそれ 生殖細胞変異原性 1A, 1B 危険
H350 発がんのおそれ 発がん性 1A, 1B 危険
H361 生殖能または胎児への悪影響のおそれの疑い 生殖毒性 2 警告 P201, P202, P281, P308+P313, P405,P501
注意書き
P201 使用前に取扱説明書を入手すること。
P202 全ての安全注意を読み理解するまで取り扱わないこ と。
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P308+P313 暴露または暴露の懸念がある場合:医師の診断/手当てを 受けること。
P405 施錠して保管すること。
P501 内容物/容器を...に廃棄すること。

カルバミン酸エチル 価格 もっと(25)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ACSP-419N カルバミド酸エチル
Ethyl carbamate
51-79-6 10mg ¥4400 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01ACSAS-E0306 ウレタン Standard
Urethane Standard, 5.0 mg/mL in MeOH
51-79-6 1mL ¥11800 2018-12-26 購入
東京化成工業 C0028 カルバミン酸エチル >98.0%(GC)(N)
Ethyl Carbamate >98.0%(GC)(N)
51-79-6 100g ¥5400 2018-12-04 購入
東京化成工業 C0028 カルバミン酸エチル >98.0%(GC)(N)
Ethyl Carbamate >98.0%(GC)(N)
51-79-6 25g ¥2200 2018-12-04 購入
関東化学株式会社(KANTO) 32554-1A ウレタン 97%
Urethane 97%
51-79-6 50g ¥3600 2018-12-13 購入

カルバミン酸エチル MSDS


Carbamic acid ethyl ester

カルバミン酸エチル 化学特性,用途語,生産方法

外観

白色, 結晶~結晶性粉末

溶解性

水及びエタノールに極めて溶けやすく、アセトンに溶けやすい。

用途

催眠剤, 水への溶解補助剤, 有機合成原料, 溶融させて極性有機溶剤など。

用途

生化学用,有機合成原料,医薬原料

使用上の注意

不活性ガス封入

説明

Ethyl carbamate occurs as colourless or white columnar crystals or granular powder. It is very soluble in water. With heat, ethyl carbamate undergoes decomposition and emits toxic fumes of carbon monoxide, carbon dioxide, and nitrogen oxides. Ethyl carbamate is used as an intermediate in the synthesis of a number of chemical products, for example, pharmaceuticals, in biochemical research and medicine, and as a solubiliser and co-solvent for pesticides and fumigants. Prior to World War II, ethyl carbamate saw relatively heavy use in the treatment of multiple myeloma before it was found to be toxic, carcinogenic, and largely ineffective. However, due to U.S. FDA regulations, ethyl carbamate has been withdrawn from pharmaceutical use. However, small quantities of ethyl carbamate are also used in laboratories as an anaesthetic for animals.

化学的特性

Colorless crystals or white powder; odorless, saltpeter-like taste. Solutions neutral to litmus. Soluble in water, alcohol, ether, glycerol, and chloroform; slightly soluble in olive oil. Combustible.

化学的特性

Urethane is a colorless, almost odorless crystalline solid or powder.

天然物の起源

Urethane (ethyl carbamate) occurs as a natural byproduct in fermented products such as wine, liquors, yogurt, beer, bread, olives, cheeses, and soy sauces. Whereas urethane has a known cancer etiology in experimental animals, no such relationship has yet been proven in humans. Alcohol may act by blocking the metabolism of urethane, and thus exert a protective effect in humans consuming alcoholic beverages.

使用

The primary use of urethane has been as a chemical intermediate in preparation of amino resins (IARC 1974). The process involves a reaction with formaldehyde to give hydroxymethyl derivatives that are used as cross-linking agents in permanent-press textile treatments designed to impart wash-and-wear properties to fabrics. Urethane isalso used as a solubilizer and co-solvent in the manufacture of pesticides, fumigants, and cosmetics, as an intermediate in the manufacture of pharmaceuticals, and in biochemical research (HSDB 2009). Urethane was formerly used as an active ingredient in drugs prescribed for the treatment of neoplastic diseases, as a sclerosing solution for varicose veins, as a hypnotic, and as a topical bactericide. It is also used in veterinary medicine as an anesthetic (IARC 1974). Urethane is produced naturally during many fermentation processes(Zimmerli and Schlatter 1991).

使用

Naturally occurring contaminant in fermented foods, particularly wine, stone-fruit brandies, and bread. This substance is reasonably anticipated to be a human carcinogen.

使用

antiinfective

使用

Intermediate in organic synthesis. In the preparation and modification of amino resins. As solvent, solubilizer and cosolvent for various organic materials. Animal anesthetic in laboratory procedures.

定義

A poisonous flammable organic compound, used in medicine, as a solvent, and as an intermediate in the manufacture of polyurethane resins.

世界保健機関(WHO)

Urethane was formerly used as an antineoplastic agent in the treatment of chronic myeloid leukaemia. It is also a mild hypnotic which has been used as an anaesthetic for veterinary practice. It has been reported to have both a carcinogenic and mutagenic potential. Although urethane continues to be used as an industrial solvent, WHO has no information to suggest that it remains commercially available in pharmaceutical preparations.

一般的な説明

Odorless colorless crystals or white powder. Sublimes readily at 217°F and 54 mm Hg. Cooling saline taste.

空気と水の反応

Water soluble. Aqueous solutions are neutral to litmus .

反応プロフィール

Urethane is incompatible with alkalis, acids, chloral hydrate, camphor, menthol and thymol. Also incompatible with antipyrine and salol. May react with strong oxidizing agents. Liquefies with benzoic acid, resorcinol and salicylic acid. Reacts with phosphorus pentachloride to form an explosive product .

危険性

Toxic by ingestion.

安全性プロファイル

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. A transplacental carcinogen. Moderately toxic by ingestion, intraperitoneal, subcutaneous, intramuscular, parenteral, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. Causes depression of bone marrow and occasionally focal degeneration in the brain. Can also produce central nervous system depression, nausea and vomiting. Has been found in over 1000 beverages sold in the United States. The most heavily contaminated liquors are bourbons, sherries, and fruit brandies (some had 1000 to 12,000 ppb urethane). Many whiskeys, table and dessert wines, brandies, and liqueurs contain potentially hazardous amounts of urethane. The allowable limit for urethane in alcoholic beverages is 125 ppb. It is formed as a side product during processing.Hot aqueous acids or alkalies decompose urethane to ethanol, carbon dioxide, and ammonia. Reacts with phosphorus pentachloride to form an explosive product. When heated it emits toxic fumes of NOx. Used as an intermedate in the manufacture of pharmaceuticals, pesticides, and fungicides. See also CARBAMATES.

職業ばく露

Urethane is used as a chemical intermediate in manufacture of pharmaceuticals; pesticides, and fungicides; in the preparation of amino resins. It may be reacted with formaldehyde to give cross-linking agents which impart wash-and-wear properties to fabrics. It has also been used as a solubilizer and cosolvent in the manufacture of pesticides, fumigants, and cosmetics. It was formerly used in the treatment of leukemia. It occurs when diethylpyrocarbonate, a preservative used in wines, fruit juices, and soft drinks, is added to aqueous solutions.

Carcinogenicity

Urethane is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

純化方法

Urethane is best purified by fractional distillation, but it can be 20 25 1.4144. sublimed at ~103o/~50mm. It has also been recrystallised from *benzene. Its solubilitiy at room temperature is 2g/mL in H2O, 1.25g/mL in EtOH, 1.1g/mL in CHCl3, 0.67g/mL in Et2O and 0.03g/mL in olive oil. It is a suspected human carcinogen.[Beilstein 3 H 22, 3 IV 40.]

不和合性

Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, gallium, perchlorate.

廃棄物の処理

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. Controlled incineration (incinerator equipped with a scrubber or thermal unit to reduce nitrogen oxides emissions).

カルバミン酸エチル 上流と下流の製品情報

原材料

準備製品


カルバミン酸エチル 生産企業

Global( 300)Suppliers
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Henan DaKen Chemical CO.,LTD.
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info@dakenchem.com CHINA 21829 58
Henan Tianfu Chemical Co.,Ltd.
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0371-55170693 info@tianfuchem.com CHINA 22626 55
career henan chemical co
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Xiamen AmoyChem Co., Ltd
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sale@chuangyingchem.com CHINA 5921 58
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Shenzhen Sendi Biotechnology Co.Ltd. 0755-23311925 18102838259
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+86-0592-6210733 sale@mainchem.com CHINA 32445 55
卡托研究化学公司 4000-868-328 020-81215950-
customer@uwalab.com;customer@uwalab.com United States 10425 58

51-79-6(カルバミン酸エチル)キーワード:


  • 51-79-6
  • a11032
  • Aethylcarbamat
  • Aethylurethan
  • ai3-00553
  • Aminoformicacidethylester.
  • carbamated’ethyle
  • Carbamidsaeure-aethylester
  • Estane 5703
  • Ethyl ester of carbamic acid
  • Ethyl urethan
  • Ethylaminoformate
  • Ethylester kyseliny karbaminove
  • ethylesterkyselinykarbaminove
  • ethylesterkyselinykarbaminove(czech)
  • ethylurethan
  • Leucethane
  • Leucothane
  • NH2COOC2H5
  • NSC 746
  • nsc746
  • nsc-746
  • O-Ethylurethane
  • Pracarbamin
  • Pracarbamine
  • Rcra waste number U238
  • rcrawastenumberu238
  • U-Compound
  • Uretan
  • Uretan etylowy
  • uretanetylowy
  • カルバミン酸エチル
  • プラカルバミン
  • エチルウレタン
  • エチルカルバマート
  • エスタン-5703
  • カルバミド酸エチル
  • アミノぎ酸エチル
  • ウレタン
  • ウレタン(カルバミン酸エチル)
  • エチル=カルバマート
  • カルバミン酸エチル ウレタン
  • カルバミド酸エチル STANDARD
  • カルバミン酸エチル標準品
  • ウレタン STANDARD
  • ウレタン, 結晶
  • ウレタン Standard, 5.0 mg/mL in MeOH
  • カルバミド酸エチル Standard, 100 µg/mL in MeOH
  • 発癌物質
  • 抗腫瘍薬
  • 麻酔薬
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