Nω-ニトロ-L-アルギニンメチル塩酸塩 化学特性,用途語,生産方法
外観
白色の結晶~結晶性粉末
溶解性
水に可溶。、エタノール及びアセトンにほとんど溶けない。
用途
NO合成酵素(NOS)阻害剤、NOの生体内での生理活性発現機構の解析。
説明
L-
NAME requires hydrolysis of the methyl ester by cellular esterases to become a fully functional inhibitor (L-
NNA). L-
NNA exhibits some selectivity for inhibition of neuronal and endothelial isoforms. It exhibits K
i values of 15 nM, 39 nM, and 4.4 μM for nNOS (bovine), eNOS (human), and iNOS (mouse), respectively. The reported K
i value for the inhibition of iNOS ranges from 4-
65 μM. L-
NAME inhibits cGMP formation in endothelial cells with an IC
50 of 3.1 μM (in the presence of 30 μM arginine) and reverses the vasodilation effects of acetylcholine in rat aorta rings with an EC
50 of 0.54 μM.
化学的特性
Crystalline
使用
Nitroarginine Methyl Ester Hydrochloride is used in the synthesis of N/CD13 inhibitors playing an important role in tumor invasion, metastatsis and angiogenesis. Also used in the preparation of spirocyclic lactam as a type II’ β-turn inducer.
定義
ChEBI: A hydrochloride obtained by combining Ngamma-nitro-L-arginine methyl ester with one equivalent of hydrochloric acid.
一般的な説明
More soluble analog of arginine and a competitive, slowly reversible inhibitor of endothelial nitric oxide synthase (IC
50 = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC
50 = 400 nM).
生物活性
NO synthase inhibitor.
Nω-ニトロ-L-アルギニンメチル塩酸塩 上流と下流の製品情報
原材料
準備製品