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無水エデト酸二ナトリウム

無水エデト酸二ナトリウム 化学構造式
139-33-3
CAS番号.
139-33-3
化学名:
無水エデト酸二ナトリウム
别名:
エチレンジアミン四酢酸二ナトリウム溶液 [水の硬度測定用] [ppm用];(エチレンビスニトリロ)四酢酸1,1''-ジナトリウム;(エチレンビスニトリロ)四酢酸1,1''-二ナトリウム;エデト酸ジナトリウム;エチレンジニトリロ四酢酸二水素1,1''-二ナトリウム;3,6-ビス[(ソジオオキシカルボニル)メチル]-3,6-ジアザオクタン二酸;EDTAジナトリウム;EDTA二ナトリウム;エチレンジアミン四酢酸ジナトリウム;エデチン酸二ナトリウム;エチレンジアミン-N,N,N',N'-四酢酸二水素N,N'-二ナトリウム;コンプレキソンIII;エチレンジアミン四酢酸二ナトリウム;エチレンジアミンテトラ酢酸二ナトリウム;EDTA-2Na;HW 34550-10L-VOLPAC エチレンジアミン四酢酸二ナトリウム塩 SOLUTION REAG. PH. EUR.,VOLUMETRIC,0.1 M EDTA-NA2,FO;HW 34550-5L-VOLPAC エチレンジアミン四酢酸二ナトリウム塩 SOLUTION REAG. PH. EUR.,VOLUMETRIC,0.1 M EDTA-NA2,FOR;HW 35102-10L-VOLPAC エチレンジアミン四酢酸二ナトリウム塩 SOLUTION VOLUMETRIC,0.2 M EDTA-NA2,FOR COMPLEXOMETRY;HW 35102-5L-VOLPAC エチレンジアミン四酢酸二ナトリウム塩 SOLUTION VOLUMETRIC,0.2 M EDTA-NA2,FOR COMPLEXOMETRY;エチレンジアミン四酢酸二ナトリウム塩 SOLUTION REAG. PH. EUR.,VOLUMETRIC,0.1 M EDTA-NA2,FOR COMPLEXOMETRY
英語化学名:
Ethylenediaminetetraacetic acid disodium salt
英語别名:
ETA;EDNRA;Gpcr10;hET-AR;4C EDTA;Disotate;EDTA-2NA;EDTA NA2;trilonbd;RATENDOR
CBNumber:
CB8371263
化学式:
C10H14N2Na2O8
分子量:
336.21
MOL File:
139-33-3.mol

無水エデト酸二ナトリウム 物理性質

融点 :
248 °C (dec.)(lit.)
沸点 :
>100 °C
比重(密度) :
1.01 g/mL at 25 °C
貯蔵温度 :
2-8°C
溶解性:
H2O: clear, colorless
外見 :
solution
色:
≤5 (0.5 M)(APHA)
水溶解度 :
Miscible with water.
BRN :
3822669
CAS データベース:
139-33-3(CAS DataBase Reference)
EPAの化学物質情報:
Ethylenediaminetetraacetic acid disodium salt (139-33-3)

安全性情報

主な危険性  Xn,C
Rフレーズ  36/38-36/37/38-22-34-21/22
Sフレーズ  26-36-37/39-45-36/37/39-36/37
WGK Germany  2
RTECS 番号 AH4410000
TSCA  Yes
HSコード  29224999
有毒物質データの 139-33-3(Hazardous Substances Data)
化審法 (2)-1265

無水エデト酸二ナトリウム 価格 もっと(41)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
Sigma-Aldrich Japan 2854 エチレンジアミン四酢酸 二ナトリウム塩 溶液 2%, solution
Ethylenediaminetetraacetic acid disodium salt solution 2%, solution
139-33-3 15ml ¥12800 2021-03-23 購入
Sigma-Aldrich Japan 09-1480
Ethylenediaminetetraacetic acid disodium salt solution
139-33-3 500 mL ¥2010 2021-03-23 購入
Sigma-Aldrich Japan 09-1480 エチレンジアミン四酢酸 二ナトリウム塩 溶液
Ethylenediaminetetraacetic acid disodium salt solution
139-33-3 5-500ml-j ¥1900 2018-12-25 購入
林純薬工業株式会社 44011495
10W/V% Disodium dihydrogen ethylenediamine tetraacetic acid solution pH 7.010W/V% EDTA・2Na溶液 pH 7.0
139-33-3 500mL ¥4400 2021-03-22 購入
林純薬工業株式会社 42008449
0.05mol/L Disodium dihydrogen ethylenediamine tetraacetic acid solution0.05mol/L EDTA・2Na溶液
139-33-3 20L ¥30600 2021-03-22 購入

無水エデト酸二ナトリウム MSDS


(Ethylenedinitrilo)tetraacetic acid disodium salt

無水エデト酸二ナトリウム 化学特性,用途語,生産方法

定義

本品は、エチレンジアミン四酢酸(EDTA(*))の二ナトリウム塩であり、次の化学式で表されるジアミン誘導体である。
参照表示名称:EDTA

化粧品の成分用途

キレート剤

効能

金属キレート剤

化学的特性

Disodium edetate occurs as a white crystalline, odorless powder with a slightly acidic taste.

Originator

Endrate Disodium,Bersworth,US,1959

使用

Chelating agent (metal); pharmaceutic aid (chelating agent).

使用

disodium EDTA is a preservative used in concentrations of 0.1 to 0.5 percent.

使用

Disodium Dihydrogen EDTA is a sequestrant and chelating agent whose complete name is disodium ethylenediamine tetraacetate. it is a nonhygroscopic powder that is colorless, odorless, and tasteless at recommended use levels. A 1% solution has a ph of 4.3–4.7. It is used to control the reaction of trace metals to include calcium and magnesium with other organic and inorganic components in food to prevent deterioration of color, texture, and development of precipitates and to prevent oxidation. Its function is comparable to that of disodium calcium edta.

使用

Ethylenediaminetetraacetic acid disodium salt is widely used in textile industry. Usually applied to dissolve limescale. It is applied in textile industry, pulp and paper industry and also in chelation therapy. In cosmetics, it acts as a sequestering agent. It acts as a corrosion inhibitor to carbon steel in the industries. It also acts as a food additive.

主な応用

Ethylenediaminetetraacetic acid disodium salt dihydrate has been in seed germination trials of plant species and in protein extraction from Moss, Physcomitrella paten. It has also been used in lysis and vacuole buffer for the isolation of vacuoles from Petunia petals.
Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

定義

ChEBI: An organic sodium salt that is the anhydrous form of the disodium salt of ethylenediaminetetraacetic acid (EDTA).

調製方法

Disodium edetate may be prepared by the reaction of edetic acid and sodium hydroxide.

Manufacturing Process

10 mols of ethylene diamine as a 30% aqueous solution and 4 mols of solid caustic soda are placed in a steam heated kettle supplied with an agitator. 8 mols of sodium cyanide as a concentrated water solution (about 30%) are added and the solution heated to 60°C. About a 10 inch vacuum is applied to bring the liquid to incipient boiling. Formaldehyde (7.5 mols of 37% to 40% aqueous solution) is slowly added, the temperature being held at 60°C, and the solution vigorously stirred. Then, when the evolution of ammonia has substantially stopped, an additional 8 mols of sodium cyanide, followed by 8 mols of formaldehyde are added as before. This is continued until 40 mols of cyanide and 40 mols of formaldehyde have been added. Then at the end about 2 mols more of formaldehyde are added, making 42 mols in all, to remove any last traces of cyanide. About 8 to 10 hours are required to complete the reaction. The resulting product, referred to herein as the crude reaction product, is essentially an aqueous solution of the sodium salt of ethylene diamine tetracetic acid.
To 1,000 g of the crude reaction product are added 264 g of ethylene diamine tetracetic acid. The mixture is preferably heated to incipient boiling to increase the rate of reaction, and then the mixture is allowed to cool and crystallize. The crystals formed are filtered off, washed with the smallest possible amount of ice water, and dried to a constant weight, which is 452 g. A representative sample of the product so prepared showed, upon analysis, 13.26% sodium against a theoretical of 13.70% for the disodium salt. The dialkali salt has a pH of about 5.3 and behaves like a weak acid, displacing CO2 from carbonates and reacting with metals to form hydrogen. It is a white crystalline solid.

brand name

Endrate (Hospira); Sodium Versenate (3M Pharmaceuticals).

Therapeutic Function

Pharmaceutic aid (chelating agent)

応用例(製薬)

Disodium edetate is used as a chelating agent in a wide range of pharmaceutical preparations, including mouthwashes, ophthalmic preparations, and topical preparations, typically at concentrations between 0.005 and 0.1% w/v.
Disodium edetate forms stable water-soluble complexes (chelates) with alkaline earth and heavy-metal ions. The chelated form has few of the properties of the free ion, and for this reason chelating agents are often described as ‘removing’ ions from solution, a process known as sequestering. The stability of the metal–edetate complex is dependent on the metal ion involved and the pH.
Disodium edetate is also used as a water softener as it will chelate calcium and magnesium ions present in hard water. It is also used therapeutically as an anticoagulant as it will chelate calcium and prevent the coagulation of blood in vitro. Concentrations of 0.1% w/v are used in small volumes for hematological testing and 0.3% w/v in transfusions.

安全性プロファイル

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Mutation data reported. The calcium disodium salt of EDTA is used as a chelating agent in treating lead poisoning. When heated to decomposition it emits toxic fumes of NOx and NasO.

安全性

Disodium edetate is used widely in topical, oral, and parenteral pharmaceutical formulations; it is used extensively in cosmetic and food products. Disodium edetate and edetate calcium disodium are used in a greater number and variety of pharmaceutical formulations than is edetic acid. Both disodium edetate and edetate calcium disodium are poorly absorbed from the gastrointestinal tract and are associated with few adverse effects when used as excipients in pharmaceutical formulations.
Disodium edetate, trisodium edetate, and edetic acid readily chelate calcium and can, in large doses, cause calcium depletion (hypocalcemia) if used over an extended period of time, or if administered too rapidly by intravenous infusion. If used in preparations for the mouth, they can also leach calcium from the teeth. However, edetate calcium disodium does not chelate calcium.
Disodium edetate should be used with caution in patients with renal impairment, tuberculosis, and impaired cardiac function.
Although disodium edetate is generally considered safe, there have been reports of disodium edetate toxicity in patients receiving chelation therapy.
Nasal formulations containing benzalkonium chloride and disodium edetate, both known to be local irritants, were shown to produce an inflammatory reaction, and microscopic examination showed an extended infiltration of the mucosa by eosinophils, and pronounced atrophy and disorganization of the epithelium, although these effects were subsequently shown to be reversible.
The WHO has set an estimated acceptable daily intake for disodium EDTA in foodstuffs of up to 2.5 mg/kg body-weight
LD50 (mouse, IP): 0.26 g/kg
LD50 (mouse, IV): 0.056 g/kg
LD50 (mouse, OP): 2.05 g/kg
LD50 (rabbit, IV): 0.047 g/kg
LD50 (rabbit, OP): 2.3 g/kg
LD50 (rat, OP): 2.0 g/kg

Veterinary Drugs and Treatments

Edetate Disodium (Sodium EDTA) is a chelating agent that is also used to stop the melting effect of collagenases and proteases on the cornea. EDTA is useful in halting melting through inhibition of matrix metalloproteinases, but is not felt to be useful for melting caused by infectious agents. As the effect of EDTA on metalloproteinases is reversible, it must be administered several times daily to be effective.

貯蔵

Edetate salts are more stable than edetic acid (see also Edetic acid). However, disodium edetate dihydrate loses water of crystallization when heated to 120°C. Aqueous solutions of disodium edetate may be sterilized by autoclaving, and should be stored in an alkali-free container.
Disodium edetate is hygroscopic and is unstable when exposed to moisture. It should be stored in a well-closed container in a cool, dry place.

不和合性

Disodium edetate behaves as a weak acid, displacing carbon dioxide from carbonates and reacting with metals to form hydrogen. It is incompatible with strong oxidizing agents, strong bases, metal ions, and metal alloys.

規制状況(Regulatory Status)

GRAS listed. Included in the FDA Inactive Ingredients Database (inhalations; injections; ophthalmic preparations; oral capsules, solutions, suspensions, syrups, and tablets; rectal topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

無水エデト酸二ナトリウム 上流と下流の製品情報

原材料

準備製品


無水エデト酸二ナトリウム 生産企業

Global( 499)Suppliers
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139-33-3(無水エデト酸二ナトリウム)キーワード:


  • 139-33-3
  • SEQUESTRENE NA2
  • SODIUM (DI) ETHYLENEDIAMINE TETRAACETATE DIHYDRATE
  • VERSENE NA, DIHYDRATE
  • VERSENE DISODIUM
  • WANKLYN'S EDTA
  • Ceftriaxone Impurity 21(EDTA Disodium)
  • disodium ethylenediamintetraacetate
  • EDTA two sodium
  • EDTA TITRANT 0.05M VOL SOL
  • EDTA disodium salt solution, 0.1000mol/L(0.1M)
  • EDTA disodium salt solution, 0.2000mol/L(0.2M)
  • EDTA disodium salt solution, 0.02000mol/L(0.02M)
  • EDTA disodium salt solution, 0.01000mol/L(0.01M)
  • Disodium Ethylenediaminetetraacetic Acid Salt
  • Ethylenediaminetetraacetic acid disodium salt(EDTA)
  • TITRAVER(R) HARDNESS REAGENT
  • TITRIPLEX III
  • TITRIPLEX(R) III
  • (Ethylenedinitrilo)tetraacetic acid disodium salt, EDTA disodium salt, Ethylenediaminetetraacetic acid solution disodium salt, Ethylenediaminetetraacetic acid disodium salt standard solution
  • IDRANAL(R) III standard solution
  • IDRANAL(R) III concentrate
  • (Ethylenedinitrilo)tetraacetic acid disodium salt, EDTA disodium salt, Ethylenediaminetetraacetic acid solution disodium salt
  • Ethylenediamine-tetraacetic acid disodium salt concentrate
  • (Ethylenedinitrilo)tetraacetic acid disodium salt, Additive Screening Solution 43/Fluka kit no 78374, EDTA disodium salt
  • Disotate
  • Ethylenediaminetetraacetic acid, disodium salt, dnase, rnase and protease free, for
  • Ethylenediaminetetraacetic acid, disodium salt, DNAse, RNAse and Protease free, for molecular biology
  • Ethylenediaminetetraacetic Acid Disodium Salt Solution [for Determination of water hardness] [for ppm]
  • (Ethylenebisnitrilo)tetraacetic acid 1,1''-disodium salt
  • Ethylenedinitrilotetraacetic acid dihydrogen 1,1''-disodium salt
  • エチレンジアミン四酢酸二ナトリウム溶液 [水の硬度測定用] [ppm用]
  • (エチレンビスニトリロ)四酢酸1,1''-ジナトリウム
  • (エチレンビスニトリロ)四酢酸1,1''-二ナトリウム
  • エデト酸ジナトリウム
  • エチレンジニトリロ四酢酸二水素1,1''-二ナトリウム
  • 3,6-ビス[(ソジオオキシカルボニル)メチル]-3,6-ジアザオクタン二酸
  • EDTAジナトリウム
  • EDTA二ナトリウム
  • エチレンジアミン四酢酸ジナトリウム
  • エデチン酸二ナトリウム
  • エチレンジアミン-N,N,N',N'-四酢酸二水素N,N'-二ナトリウム
  • コンプレキソンIII
  • エチレンジアミン四酢酸二ナトリウム
  • エチレンジアミンテトラ酢酸二ナトリウム
  • EDTA-2Na
  • HW 34550-10L-VOLPAC エチレンジアミン四酢酸二ナトリウム塩 SOLUTION REAG. PH. EUR.,VOLUMETRIC,0.1 M EDTA-NA2,FO
  • HW 34550-5L-VOLPAC エチレンジアミン四酢酸二ナトリウム塩 SOLUTION REAG. PH. EUR.,VOLUMETRIC,0.1 M EDTA-NA2,FOR
  • HW 35102-10L-VOLPAC エチレンジアミン四酢酸二ナトリウム塩 SOLUTION VOLUMETRIC,0.2 M EDTA-NA2,FOR COMPLEXOMETRY
  • HW 35102-5L-VOLPAC エチレンジアミン四酢酸二ナトリウム塩 SOLUTION VOLUMETRIC,0.2 M EDTA-NA2,FOR COMPLEXOMETRY
  • エチレンジアミン四酢酸二ナトリウム塩 SOLUTION REAG. PH. EUR.,VOLUMETRIC,0.1 M EDTA-NA2,FOR COMPLEXOMETRY
  • エチレンジアミン四酢酸二ナトリウム塩 SOLUTION VOLUMETRIC,0.01 M EDTA-NA2,FOR COMPLEXOMETRY
  • エチレンジアミン四酢酸二ナトリウム塩 SOLUTION VOLUMETRIC,0.05 M EDTA-NA2
  • エチレンジアミン四酢酸二ナトリウム塩 SOLUTION VOLUMETRIC,0.2 M EDTA-NA2,FOR COMPLEXOMETRY
  • エチレンジアミン四酢酸二ナトリウム塩 SOLUTION VOLUMETRIC,FOR 水 HARDNESS DETERMINATION (1 ML = 1 GERMAN DEGREE OF HARDNESS IN 100 ML OF 水)
  • エチレンジアミン四酢酸二ナトリウム塩濃縮物 FOR 1L STANDARD SOLUTION,0.1 M EDTA-NA2,FOR COMPLEXOMETRY
  • 0.01MOL/L エチレンジアミン四酢酸二水素二ナトリウム溶液 (M/100 EDTA-2NA)
  • 0.025MOL/L エチレンジアミン四酢酸二水素二ナトリウム溶液 (M/40 EDTA-2NA)
  • 0.02MOL/L エチレンジアミン四酢酸二水素二ナトリウム溶液(M/50 EDTA-2NA)
  • 0.05MOL/L エチレンジアミン四酢酸二水素二ナトリウム溶液 (M/20 EDTA-2NA)
  • 0.1MOL/L エチレンジアミン四酢酸二水素二ナトリウム溶液 (M/10 EDTA-2NA)
  • エチレンジアミン四酢酸 二ナトリウム塩 溶液
  • チトリプレックス™ III
  • 無水エデト酸二ナトリウム
  • キレート試薬
  • コンプレクソン
  • 分析化学
  • EDTA類縁体
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