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에틸렌디아민테트라아세트산, 이나트륨 염

에틸렌디아민테트라아세트산, 이나트륨 염
에틸렌디아민테트라아세트산, 이나트륨 염 구조식 이미지
카스 번호:
139-33-3
한글명:
에틸렌디아민테트라아세트산, 이나트륨 염
동의어(한글):
에틸렌디아민테트라아세트산,이나트륨염;에틸렌디아민테트라아세트산;다이소듐이디티에이;에틸렌디아민테트라아세트산,이나트륨염
상품명:
Ethylenediaminetetraacetic acid disodium salt
동의어(영문):
ETA;EDNRA;Gpcr10;hET-AR;4C EDTA;Disotate;EDTA-2NA;EDTA NA2;trilonbd;RATENDOR
CBNumber:
CB8371263
분자식:
C10H14N2Na2O8
포뮬러 무게:
336.21
MOL 파일:
139-33-3.mol

에틸렌디아민테트라아세트산, 이나트륨 염 속성

녹는점
248 °C (dec.)(lit.)
끓는 점
>100 °C
밀도
1.01 g/mL at 25 °C
저장 조건
2-8°C
용해도
H2O: clear, colorless
물리적 상태
solution
색상
≤5 (0.5 M)(APHA)
수용성
Miscible with water.
BRN
3822669
CAS 데이터베이스
139-33-3(CAS DataBase Reference)
EPA
Ethylenediaminetetraacetic acid disodium salt (139-33-3)

안전

위험품 표기 Xn,C
위험 카페고리 넘버 36/38-36/37/38-22-34-21/22
안전지침서 26-36-37/39-45-36/37/39-36/37
WGK 독일 2
RTECS 번호 AH4410000
TSCA Yes
HS 번호 29224999
유해 물질 데이터 139-33-3(Hazardous Substances Data)
기존화학 물질 KE-13651

에틸렌디아민테트라아세트산, 이나트륨 염 MSDS


(Ethylenedinitrilo)tetraacetic acid disodium salt

에틸렌디아민테트라아세트산, 이나트륨 염 C화학적 특성, 용도, 생산

용도

비누 / 세제 : 칼슘 및 마그네슘 비누 형성의 예방; 비누와 세제의 세제를 개선합니다. 과 붕산염과과 탄산염 표백제를 안정화시킵니다.
화학 세척 : 옥살산 칼슘, 황산 칼슘, 탄산 칼슘, 황산 바륨, 및 공정 설비로부터의 다른 타입의 스케일을 제거한다.
I & I 청소기 : 스케일을 용해 스케일 형성을 방지, 계면 활성제의 세정력을 향상시킨다. 농축 된 액체 세제 및 샴푸의 탁도를 방지합니다. 유제, 윤활제 및 광택제에 대한 다가 금속 이온의 효과를 최소화합니다.
금속 마감 : 금속 제품의 산화막의 제거; 알칼리성 파쇄; 침산 조의 정전기 방지제; 알칼리 탈지.
섬유가 : 정련에 금속 이온을 제어, 종기 오프, 표백, 염색, 제거하고 작업을 마무리합니다. 형광 증 백제를 금속 촉매 산화 및 분해로부터 보호합니다. 염료의 변색을 방지합니다.
펄프 / 종이 : 수력 표백제의 효율성을 향상; 금속 촉매 밝기 복귀를 감소시킵니다. 스케일 제거 공정 장비에 사용됩니다. 염료가 금속으로 침전되는 것을 방지합니다.

화학적 성질

Disodium edetate occurs as a white crystalline, odorless powder with a slightly acidic taste.

Originator

Endrate Disodium,Bersworth,US,1959

용도

disodium EDTA is a preservative used in concentrations of 0.1 to 0.5 percent.

용도

Disodium Dihydrogen EDTA is a sequestrant and chelating agent whose complete name is disodium ethylenediamine tetraacetate. it is a nonhygroscopic powder that is colorless, odorless, and tasteless at recommended use levels. A 1% solution has a ph of 4.3–4.7. It is used to control the reaction of trace metals to include calcium and magnesium with other organic and inorganic components in food to prevent deterioration of color, texture, and development of precipitates and to prevent oxidation. Its function is comparable to that of disodium calcium edta.

용도

Chelating agent (metal); pharmaceutic aid (chelating agent).

정의

ChEBI: An organic sodium salt that is the anhydrous form of the disodium salt of ethylenediaminetetraacetic acid (EDTA).

주요 응용

Ethylenediaminetetraacetic acid disodium salt dihydrate has been in seed germination trials of plant species and in protein extraction from Moss, Physcomitrella paten. It has also been used in lysis and vacuole buffer for the isolation of vacuoles from Petunia petals.
Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

생산 방법

Disodium edetate may be prepared by the reaction of edetic acid and sodium hydroxide.

Manufacturing Process

10 mols of ethylene diamine as a 30% aqueous solution and 4 mols of solid caustic soda are placed in a steam heated kettle supplied with an agitator. 8 mols of sodium cyanide as a concentrated water solution (about 30%) are added and the solution heated to 60°C. About a 10 inch vacuum is applied to bring the liquid to incipient boiling. Formaldehyde (7.5 mols of 37% to 40% aqueous solution) is slowly added, the temperature being held at 60°C, and the solution vigorously stirred. Then, when the evolution of ammonia has substantially stopped, an additional 8 mols of sodium cyanide, followed by 8 mols of formaldehyde are added as before. This is continued until 40 mols of cyanide and 40 mols of formaldehyde have been added. Then at the end about 2 mols more of formaldehyde are added, making 42 mols in all, to remove any last traces of cyanide. About 8 to 10 hours are required to complete the reaction. The resulting product, referred to herein as the crude reaction product, is essentially an aqueous solution of the sodium salt of ethylene diamine tetracetic acid.
To 1,000 g of the crude reaction product are added 264 g of ethylene diamine tetracetic acid. The mixture is preferably heated to incipient boiling to increase the rate of reaction, and then the mixture is allowed to cool and crystallize. The crystals formed are filtered off, washed with the smallest possible amount of ice water, and dried to a constant weight, which is 452 g. A representative sample of the product so prepared showed, upon analysis, 13.26% sodium against a theoretical of 13.70% for the disodium salt. The dialkali salt has a pH of about 5.3 and behaves like a weak acid, displacing CO2 from carbonates and reacting with metals to form hydrogen. It is a white crystalline solid.

상표명

Endrate (Hospira); Sodium Versenate (3M Pharmaceuticals).

Therapeutic Function

Pharmaceutic aid (chelating agent)

Pharmaceutical Applications

Disodium edetate is used as a chelating agent in a wide range of pharmaceutical preparations, including mouthwashes, ophthalmic preparations, and topical preparations, typically at concentrations between 0.005 and 0.1% w/v.
Disodium edetate forms stable water-soluble complexes (chelates) with alkaline earth and heavy-metal ions. The chelated form has few of the properties of the free ion, and for this reason chelating agents are often described as ‘removing’ ions from solution, a process known as sequestering. The stability of the metal–edetate complex is dependent on the metal ion involved and the pH.
Disodium edetate is also used as a water softener as it will chelate calcium and magnesium ions present in hard water. It is also used therapeutically as an anticoagulant as it will chelate calcium and prevent the coagulation of blood in vitro. Concentrations of 0.1% w/v are used in small volumes for hematological testing and 0.3% w/v in transfusions.

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Mutation data reported. The calcium disodium salt of EDTA is used as a chelating agent in treating lead poisoning. When heated to decomposition it emits toxic fumes of NOx and NasO.

Safety

Disodium edetate is used widely in topical, oral, and parenteral pharmaceutical formulations; it is used extensively in cosmetic and food products. Disodium edetate and edetate calcium disodium are used in a greater number and variety of pharmaceutical formulations than is edetic acid. Both disodium edetate and edetate calcium disodium are poorly absorbed from the gastrointestinal tract and are associated with few adverse effects when used as excipients in pharmaceutical formulations.
Disodium edetate, trisodium edetate, and edetic acid readily chelate calcium and can, in large doses, cause calcium depletion (hypocalcemia) if used over an extended period of time, or if administered too rapidly by intravenous infusion. If used in preparations for the mouth, they can also leach calcium from the teeth. However, edetate calcium disodium does not chelate calcium.
Disodium edetate should be used with caution in patients with renal impairment, tuberculosis, and impaired cardiac function.
Although disodium edetate is generally considered safe, there have been reports of disodium edetate toxicity in patients receiving chelation therapy.
Nasal formulations containing benzalkonium chloride and disodium edetate, both known to be local irritants, were shown to produce an inflammatory reaction, and microscopic examination showed an extended infiltration of the mucosa by eosinophils, and pronounced atrophy and disorganization of the epithelium, although these effects were subsequently shown to be reversible.
The WHO has set an estimated acceptable daily intake for disodium EDTA in foodstuffs of up to 2.5 mg/kg body-weight
LD50 (mouse, IP): 0.26 g/kg
LD50 (mouse, IV): 0.056 g/kg
LD50 (mouse, OP): 2.05 g/kg
LD50 (rabbit, IV): 0.047 g/kg
LD50 (rabbit, OP): 2.3 g/kg
LD50 (rat, OP): 2.0 g/kg

Veterinary Drugs and Treatments

Edetate Disodium (Sodium EDTA) is a chelating agent that is also used to stop the melting effect of collagenases and proteases on the cornea. EDTA is useful in halting melting through inhibition of matrix metalloproteinases, but is not felt to be useful for melting caused by infectious agents. As the effect of EDTA on metalloproteinases is reversible, it must be administered several times daily to be effective.

저장

Edetate salts are more stable than edetic acid (see also Edetic acid). However, disodium edetate dihydrate loses water of crystallization when heated to 120°C. Aqueous solutions of disodium edetate may be sterilized by autoclaving, and should be stored in an alkali-free container.
Disodium edetate is hygroscopic and is unstable when exposed to moisture. It should be stored in a well-closed container in a cool, dry place.

비 호환성

Disodium edetate behaves as a weak acid, displacing carbon dioxide from carbonates and reacting with metals to form hydrogen. It is incompatible with strong oxidizing agents, strong bases, metal ions, and metal alloys.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (inhalations; injections; ophthalmic preparations; oral capsules, solutions, suspensions, syrups, and tablets; rectal topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

에틸렌디아민테트라아세트산, 이나트륨 염 준비 용품 및 원자재

원자재

준비 용품


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