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ホルムアミド

ホルムアミド 化学構造式
75-12-7
CAS番号.
75-12-7
化学名:
ホルムアミド
别名:
ホルムアミド;ギ酸アミド;ハイドラナール-ホルムアミドドライ SOLVENT FOR KF TITRATION;ホルムアミド PURISS. P.A.,ACS REAGENT,≥99.5% (GC/T);ホルムアミド SPECTROPHOTOMETRIC GRADE,≥99%;ぬれ張力試験用混合液 NO.58.0;ホルムアミド 溶液
英語化学名:
Formamide
英語别名:
FORM;HCONH2;NSC 748;AMIDE C1;Formamid;FORMAMIDE;Formaride;METHANAMIDE;Formylamide;FormamideGr
CBNumber:
CB9854215
化学式:
CH3NO
分子量:
45.04
MOL File:
75-12-7.mol

ホルムアミド 物理性質

融点 :
2-3 °C(lit.)
沸点 :
210 °C(lit.)
比重(密度) :
1.134 g/mL at 25 °C(lit.)
蒸気密度:
1.55 (vs air)
蒸気圧:
0.08 mm Hg ( 20 °C)
屈折率 :
n20/D 1.447(lit.)
闪点 :
310 °F
貯蔵温度 :
Store at +2°C to +25°C.
溶解性:
H2O: 10 M at 20 °C, clear, colorless
外見 :
liquid
酸解離定数(Pka):
16.50±0.50(Predicted)
比重:
1.138 (20/20℃)
色:
clear, colorless
PH:
8-10 (200g/l, H2O, 20℃)
Relative polarity:
7.3
臭い (Odor):
Odorless
酸塩基指示薬変色域(pH):
7.1 at 23 g/l
爆発限界(explosive limit):
2.7-19.0%(V)
水溶解度 :
miscible
Sensitive :
Hygroscopic
極大吸収波長 (λmax):
λ: 275 nm Amax: 1.00
λ: 280 nm Amax: 0.20
λ: 300 nm Amax: 0.05
λ: 360 nm Amax: 0.02
λ: 400 nm Amax: 0.01
Merck :
14,4237
BRN :
505995
InChIKey:
ZHNUHDYFZUAESO-UHFFFAOYSA-N
CAS データベース:
75-12-7(CAS DataBase Reference)
NISTの化学物質情報:
Formamide(75-12-7)
EPAの化学物質情報:
Formamide (75-12-7)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T
Rフレーズ  61-41-37/38-48/22-40
Sフレーズ  53-45-36/37/39-26-23-36/37
WGK Germany  1
RTECS 番号 LQ0525000
10
自然発火温度 932 °F
TSCA  Yes
有毒物質データの 75-12-7(Hazardous Substances Data)
毒性 LD50 in mice, rats (g/kg): 4.6, 5.7 i.p. (Pham-Huu-Chanh)
消防法 危険物第4類第三石油類(水溶性)
化審法 (2)-681
安衛法 57,57-2
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H351 発がんのおそれの疑い 発がん性 2 警告 P201, P202, P281, P308+P313, P405,P501
H360 生殖能または胎児への悪影響のおそれ 生殖毒性 1A, 1B 危険
H373 長期にわたる、または反復暴露により臓器の障 害のおそれ 特定標的臓器有害性、単回暴露 2 警告 P260, P314, P501
注意書き
P201 使用前に取扱説明書を入手すること。
P202 全ての安全注意を読み理解するまで取り扱わないこ と。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P281 指定された個人用保護具を使用すること。
P308+P313 暴露または暴露の懸念がある場合:医師の診断/手当てを 受けること。
P405 施錠して保管すること。
P501 内容物/容器を...に廃棄すること。

ホルムアミド 価格 もっと(64)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01W0106-0042 ホルムアミド 98.5+% (GC) (mass/mass) (HCONH2)
Formamide 98.5+% (GC) (mass/mass) (HCONH2)
75-12-7 25mL ¥1200 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01W0106-0042 ホルムアミド 98.5+% (GC) (mass/mass) (HCONH2)
Formamide 98.5+% (GC) (mass/mass) (HCONH2)
75-12-7 100mL ¥1800 2021-03-23 購入
東京化成工業 F0045 ホルムアミド >98.5%(GC)
Formamide >98.5%(GC)
75-12-7 25g ¥1600 2021-03-23 購入
東京化成工業 F0045 ホルムアミド >98.5%(GC)
Formamide >98.5%(GC)
75-12-7 500g ¥3000 2021-03-23 購入
関東化学株式会社(KANTO) 16062-00 ホルムアミド >98.5%(GC)
Formamide >98.5%(GC)
75-12-7 500mL ¥2800 2021-03-23 購入

ホルムアミド MSDS


Formamide

ホルムアミド 化学特性,用途語,生産方法

外観

無色澄明の液体

溶解性

水及びエタノールに溶けやすく、ジエチルエーテルに極めて溶けにくい。

用途

1. DNA塩基配列決定法(マキサム・ギルバート法でのDNA変性液, Dideoxy法での停止液)2. サザンブロット法でのハイブリダイゼーション緩衝液3. ノーザンブロット法でのRNA変性液, ハイブリダイゼーション緩衝液4. S1マッピングでのハイブリダイゼーション緩衝液

用途

研究用の溶剤、試薬

用途

医薬品原料、香料

用途

医薬品、染料、顔料、その他有機合成用中間原料として使用される溶剤、たん白、合成繊維糊料、紙などの処理剤、電気化学工業の電解液

使用上の注意

吸湿性があり、湿気によって徐々に分解する。

化学的特性

Clear, colorless liquid

化学的特性

Formamide is a colorless, viscous liquid. Faint ammonia-like odor.

化学的特性

Formamide is hydrolyzed very slowly at room temperature. Acids, bases and elevated temperatures accelerate the hydrolysis (Eberling 1980).

使用

Formamide is a good solvent for proteins and salts owing to its high dielectric constant. Its main applications are as a solvent in the chemical industry, as a softener for paper, as an intermediate for the manufacturing of formic acid and esters and hydrocyanic acid, and as a reaction medium.

使用

Formamide destabilizes nucleic acid duplexes and may be used, typically, at a concentration of 50%, in hybridization protocols requiring lower hybridization temperatures.

使用

As ionizing solvent, manufacture of formic esters, hydrocyanic acid by catalytic dehydration, as softener for paper, animal glues, water-sol gums.

定義

ChEBI: The simplest monocarboxylic acid amide, obtained by formal condensation of formic acid with ammonia. The parent of the class of formaldehydes.

調製方法

Formamide is produced commercially by two processes (Eberling 1980). In a direct synthesis, ammonia and carbon monoxide react at 100-300 atm and 80-100°C in methanolic sodium methoxide. In the second, a two-stage synthesis, carbon monoxide and methanol form methylformate in the presence of sodium methoxide. The methylformate is treated with liquid or gaseous ammonia at 2-6 atm and 80-100°C.

一般的な説明

A colorless liquid with a faint odor of ammonia. Denser than water. Freezing point 36°F.

空気と水の反応

Hygroscopic. Water soluble.

反応プロフィール

Formamide is incompatible with strong oxidizers, acids and bases. Sensitive to light. Reacts with water very slowly at room temperature, but rate is accelerated by acids and bases at elevated temperatures. Incompatible with iodine, pyridine and sulfur trioxide. Reacts explosively with furfuryl alcohol, H2O2, Tl(NO3)3.H2O, nitromethane and P2O5. An effective solvent: dissolves casein, glucose, tannins, starch, lignin, polyvinyl alcohol, cellulose acetate, nylon, the chlorides of copper, lead, zinc, tin, cobalt, iron, aluminum and nickel, the acetates of the alkali metals, some inorganic sulfates and nitrates. Attacks copper and brass .

危険性

Toxic material. Toxic by skin absorption.

健康ハザード

INHALATION: A moderate irritant to mucous membranes. EYES: Moderately irritating to the eyes. SKIN: A mild to moderate irritant to the skin.

健康ハザード

Formamide is moderately irritating to the skin and mucous membranes (Windholz 1983).

农业用途

Fonnamide is an organic compound containing the amide group -CONH2. It is made from formic acid or its ester with ammonia. It is also made from ammonia and carbon monoxide.
Formamide is used in making liquid fertilizers for foliar application of nitrogen. For example, a mixture of formamide, urea and ammonium nitrate is used as a solution fertilizer and has a salt-out temperature of 0°C. It contains more than 35% nitrogen, unlike the aqueous formulations of urea, and ammonium nitrate, which have 32 % nitrogen.Formamide is a good solvent for many organic compounds.

工業用途

Formamide is used in the large scale production of formic acid by reaction with inorganic acids, as an intermediate in the chemical industry, as a solvent in the processing of plastics, and as a solvent in felt-tip pens (Eberling 1980).

安全性プロファイル

Poison by skin contact and subcutaneous routes. Moderately toxic by ingestion, intraperitoneal, and intramuscular routes. An irritant to skin, eyes, and mucous membranes. Experimental teratogenic and reproductive effects. An eye irritant. Mutation data reported. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. Incompatible with 12, pyridine,SO3. When heated to decomposition it emits toxic fumes of NOx. Has exploded while in storage.

職業ばく露

Formamide is a powerful solvent. It is also used as an intermediate in pharmaceutical manufacture.

環境運命予測

If released to air, formamide will exist solely as a vapor in the ambient atmosphere. Vapor-phase formamide will be degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals. The half-life for this reaction in air is estimated to be 8.0 days. If released to soil, formamide is expected to have very high mobility. Volatilization from moist soil surfaces is not expected to be an important fate process. If released into water, formamide is not expected to adsorb to suspended solids and sediment. Several biodegradation screening studies have observed significant biodegradation of formamide, which suggests that biodegradation may be important. Volatilization from water surfaces is not expected to be an important fate process based upon this compound’s estimated Henry’s law constant.

代謝

There are only very few reports on the metabolic fate of formamide in the literature. Halsey (1898) found that formamide gave rise to as much urinary formate in the dog as did formic acid, and assumed complete hydrolysis of the amide in vivo. In a study by Bray et al (1949) the hypothesis was tested that formamide undergoes metabolic hydrolysis in rabbits. Acidic substances were titrated after extraction by ether, before and after hydrolysis of urine samples. The ether-soluble acid determined in hydrolyzed urine was assumed to reflect the amount of formamide excreted unchanged. The difference between the amount of amide administered and the total amount excreted unchanged was considered to represent amide which was metabolically hydrolyzed. After administration of 2-4 g per rabbit orally, 39% of the dose was recovered unchanged using this method. When formamide was incubated with rabbit liver extracts or liver slices, only very little hydrolysis was detected by this method.

輸送方法

UN2810 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

純化方法

Formamide is easily hydrolysed by acids and bases. It also reacts with peroxides, acid halides, acid anhydrides, esters and (on heating) alcohols, while strong dehydrating agents convert it to a nitrile. It is very hygroscopic. Commercial material often contains acids and ammonium formate. Vorhoek [J Am Chem Soc 58 2577 1956] added some bromothymol blue to formamide and then neutralised it with NaOH before heating to 80-90o under reduced pressure to distil off ammonia and water. The amide is again neutralised and the process is repeated until the liquid remained neutral on heating. Sodium formate is added, and the formamide is concentrated under reduced pressure at 80-90o. The distillate is again neutralised and redistilled. It is then fractionally crystallised in the absence of CO2 and water by partial freezing. Formamide (specific conductance 2 x 10-7 ohm-1 cm-1) of low water content is dried by passage through a column of 3A molecular sieves, then deionized by treatment with a mixed-bed ion-exchange resin loaded with H+ and HCONH-ions (using sodium formamide in formamide)[Notley & Spiro J Chem Soc (B) 362 1966]. [Beilstein 2 IV 45.]

Toxicity evaluation

The mechanism of toxicity of formamide is not known; the response profile is quite different from the better studied dimethyl derivative.

不和合性

Forms hydrocyanic acid with water solutions. Hygroscopic (absorbs moisture from air). Incompatible with nonoxidizing mineral acids; strong acids; ammonia, cresols, iodine, isocyanates, oleum, phenols, pyr idine, sulfur trioxide; oxidizers, iodine, pyridine. Formamide decomposes on heating @ 180℃ forming ammonia, water, carbon monoxide and hydrogen cyanide. Attacks metals, such as aluminum, iron, copper, brass, lead, and natural rubber. Thermal decomposition may release deadly hydrogen cyanide. Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithio carbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur).

廃棄物の処理

Dissolve in a combustible solvent and dispose by burning in a furnace equipped with an alkali scrubber for the exit gases.

ホルムアミド 上流と下流の製品情報

原材料

準備製品

5-メチル-2-ピロール-1-イル-チオフェン-3-カルボン酸 イベルメクチン 6-アミノ-7-メチル-7H-プリン 6-ISO-プロピル-3H-チエノ[2,3-D]ピリミジン-4-オン 3'-アジド-3'-デオキシチミジン 4-メチルチアゾール ペプロマイシン 1,2,3,5-テトラヒドロ-8-チア-5,7-ジアザ-シクロペンタ[A]インデン-4-オン N,N-ジエチル-3-(2,4,6-トリメチルフェニルスルホニル)-1H-1,2,4-トリアゾール-1-カルボキサミド 5,6-ジメチルチエノ[2,3-D]ピリミジン-4(3H)-オン 4,5-ジメチルチアゾール 4-クロロ-5,6-ジメチルチエノ[2,3-D]ピリミジン キサノメリン L-酒石酸 水和物 2-チオフェンカルボキサミド 6-フェニル-3H-チエノ[2,3-D]ピリミジン-4-オン 5-メチル-4-オキソ-3,4-ジヒドロチエノ[2,3-D]-ピリミジン-6-カルボン酸エチル 4-メチル-5-エトキシオキサゾール 6-エチルチエノ[2,3-D]ピリミジン-4(3H)-オン 6-メトキシピリミジン-4-アミン 2,6-ジメルカプトプリン 酢酸2-(4-メチル-5-チアゾリル)エチル ラゾキサン セフォジジム 2,4-ジメトキシベンゼンメタンアミン ベスナリノン 4-クロロ-8-フルオロ-5H-ピリミド[5,4-B]インドール Β-D-フルクトフラノシル, Α-D-グルコピラノシド, オクタデカノアート 6-ヨード-4-キナゾロン ヨウ化物 3,4-デヒドロ-4-オキソ-7-キンゾリンカルボン酸 ジエチルスチルベストロール

ホルムアミド 生産企業

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75-12-7(ホルムアミド)キーワード:


  • 75-12-7
  • formimidicacid
  • Formylamide
  • HCONH2
  • methanoicacid,amide
  • METHANAMIDE
  • FORMIC AMIDE
  • FORMIC ACID AMIDE
  • FORMAMIDE
  • FORMAMIDE, DEIONIZED
  • CARBAMALDEHYDE
  • Formamide, for polarographic and nonaqueous titration, for analysis
  • Formamide, for spectroscopy, 99+%
  • FORMAMIDE BIO-REFINED
  • FORMAMIDE REAGENT (ACS)
  • formamide, spectrophotometric grade
  • FORMAMIDE,BIOSOLV
  • FORMAMIDE,DEIONIZED,ULTRAPURE
  • FORMAMIDE,OMNISOLV
  • FORMAMIDE,ULTRAPURE
  • FORM
  • Ameisensαureamid
  • AMIDE C1
  • AKOS BBS-00004264
  • Formamide, Spectrophotometric Grade, 99+%
  • Formamide, 99.5%
  • FORMAMIDE pure
  • FORMAMIDE extrapure AR
  • Amide C1, Formic amide
  • Formamide solution
  • Formamide, 99.5+%, extra pure
  • ホルムアミド
  • ギ酸アミド
  • ハイドラナール-ホルムアミドドライ SOLVENT FOR KF TITRATION
  • ホルムアミド PURISS. P.A.,ACS REAGENT,≥99.5% (GC/T)
  • ホルムアミド SPECTROPHOTOMETRIC GRADE,≥99%
  • ぬれ張力試験用混合液 NO.58.0
  • ホルムアミド 溶液
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