3-Oxocyclobutanecarboxylic acid
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3-Oxocyclobutanecarboxylic acid 속성
- 녹는점
- 69-70℃
- 끓는 점
- 296°C
- 밀도
- 1.431
- 인화점
- 147°C
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 4.35±0.20(Predicted)
- 색상
- 회백색
- 수용성
- 물에 약간 용해됩니다.
- InChI
- InChI=1S/C5H6O3/c6-4-1-3(2-4)5(7)8/h3H,1-2H2,(H,7,8)
- InChIKey
- IENOFRJPUPTEMI-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)CC(=O)C1
- CAS 데이터베이스
- 23761-23-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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신호 어: | Danger | ||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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3-Oxocyclobutanecarboxylic acid C화학적 특성, 용도, 생산
개요
3-Oxocyclobutanecarboxylic acid is an organic common intermediate compound used in pharmaceuticals, organic synthesis and organic light-emitting diode (OLED) intermediates. Abrocitinib, prepared from 3-Oxocyclobutanecarboxylic acid, is approved for the treatment of adult patients with atopic dermatitis (AD), as well as patients with refractory moderate to severe AD who have had limited or minimal response to other systemic medications.화학적 성질
White solid용도
3-Oxocyclobutanecarboxylic Acid (cas# 23761-23-1) is a compound useful in organic synthesis.주요 응용
3-Oxocyclobutanecarboxylic acid is a very important medicine intermediate, it is widely applied in the synthetic of tens kinds of bulk drugs, such as ACK1 antibody, the MDM2 antagonist, the JAK inhibitor, CETP inhibitor, kinase inhibitor, the PDE10 inhibitor, thrombin inhibitors and in autoimmunization chronic inflammatory diseases and antitumor drug, all being used to.제조 방법
The target product 3-oxocyclobutanecarboxylic acid is obtained by adopting acetone, bromine, and malononitrile as raw materials, adopting ethanol, DMF (dimethyl formamide), and water as solvents, adopting sodium iodide as an activating agent and tetrabutylammonium bromide (TBAB) as a phase transfer catalyst through three-step reaction.Synthesis Reference(s)
The Journal of Organic Chemistry, 53, p. 3841, 1988 DOI: 10.1021/jo00251a0333-Oxocyclobutanecarboxylic acid 준비 용품 및 원자재
원자재
준비 용품
3,3-디플루오로시클로부탄카르복실산
5,8-디옥사스피로[3.4]옥탄-2-메탄올
메틸3-브로모시클로부탄-1-카르복실레이트
3-브로모사이클로부타논
3-히드록시-시클로부탄카르복실산에틸에스테르
메틸시스-3-히드록시시클로부탄카르복실레이트
카르밤산,(3-히드록시시클로부틸)-,1,1-디메틸에틸에스테르(9CI)
3-메틸렌사이클로부탄카복실산
3-옥소-시클로부탄카르복실산2,5-디옥소-피롤리딘-1-일에스테르
isopropyl3-oxocyclobutane-1-carboxylate
사이클로부탄카복사미드,N,N-디메틸-3-옥소-,디에틸아세탈(6CI)
3,3-difluorocyclobutane-1-carbonyl chloride
N-((3-클로로피라진-2-일)메틸)-3-옥소사이클로부탄카복사미드
3-Oxocyclobutanecarboxylic acid 공급 업체
글로벌( 513)공급 업체
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Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
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