펜플루라민하이드로클로라이드

펜플루라민하이드로클로라이드
펜플루라민하이드로클로라이드 구조식 이미지
카스 번호:
404-82-0
한글명:
펜플루라민하이드로클로라이드
동의어(한글):
펜플루라민하이드로클로라이드
상품명:
Fenfluramine hydrochloride
동의어(영문):
FENFLURAMINE HCL;ponderal;ponderax;FENFLURAMINE HYDROCHLORIDE;FEBFLURAMINE HYDROCHLORIDE;phenfluoraminehydrochloride;rac Fenfluramine Hydrochloride;2H6]-Fenfluramine hydrochloride;(+/-)-FENFLURAMINE HYDROCHLORIDE;Fenfluramine hydrochloride USP/EP/BP
CBNumber:
CB0314194
분자식:
C12H17ClF3N
포뮬러 무게:
267.72
MOL 파일:
404-82-0.mol

펜플루라민하이드로클로라이드 속성

녹는점
1660C
끓는 점
108-112 °C(Press: 12 Torr)
저장 조건
2-8°C
용해도
클로로포름(약간 용해됨), DMSO(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태
고체
안정성
흡습성
CAS 데이터베이스
404-82-0(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T
위험 카페고리 넘버 25-23/24/25
안전지침서 7-16-36/37-45-36/37/39-22
유엔번호(UN No.) UN 2811 6.1/PG 3
WGK 독일 3
RTECS 번호 DA0295500
위험 등급 6.1(b)
포장분류 III
독성 LD50 oral in rabbit: 50mg/kg
그림문자(GHS): GHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H300 삼키면 치명적임 급성 독성 물질 - 경구 구분 1,2 위험 GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P321 (…) 처치를 하시오.
P330 입을 씻어내시오.
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
3
0 0

펜플루라민하이드로클로라이드 C화학적 특성, 용도, 생산

화학적 성질

Crystalline Solid

용도

Controlled substance. Anorexic

정의

ChEBI: The hydrochloride salt of fenfluramine. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine hydrochloride was used for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

일반 설명

Fenfluramine hydrochloride, (±)N-ethyl- -methyl-m-(trifluoromethyl)phenethylamine hydrochloride (Pondimin), isunique in this group of drugs, in that it tends to produce sedationrather than excitation. Effects are said to be mediatedprincipally by central serotoninergic, rather than central noradrenergic,mechanisms. In large doses in experimental animals,the drug is a serotonin neurotoxin.It was withdrawnfrom human use after reports of heart valve damage and pulmonaryhypertension. From its structure, more apolar or hydrophobiccharacter than amphetamine, tropism for serotoninergicneurons would be expected. Likewise, thestructure suggests an indirect mechanism. If an indirectmechanism were operative, then all postsynaptic 5-HT receptors could be activated. Evidence from several studies indicatesthat the 5-HT1B and the 5-HT2C receptors are mostresponsible for the satiety effects of 5-HT. 5-HT may alsoinfluence the type of food selected (e.g., lower-fat food intake).The(+) isomer, dexfenfluramine (Redux), has agreater tropism for 5-HT systems than the racemic mixture.It, too, was withdrawn because of toxicity.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: mydriasis, change in motor activity, nausea. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of F-, NOx, and HCl

펜플루라민하이드로클로라이드 준비 용품 및 원자재

원자재

준비 용품


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