트리암테렌
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트리암테렌 속성
- 녹는점
- 316°C
- 끓는 점
- 386.46°C (rough estimate)
- 밀도
- 1.3215 (rough estimate)
- 굴절률
- 1.8260 (estimate)
- 인화점
- 11 °C
- 저장 조건
- 2-8°C
- 용해도
- 포름산: 가용성 200 mg + 4 mL 따뜻한 포름산, 투명, 황록색
- 산도 계수 (pKa)
- 6.2(at 25℃)
- 색상
- 연한 노란색에서 노란색까지
- 수용성
- 20°C에서 <0.1g/100mL
- Merck
- 14,9599
- BRN
- 266723
- InChIKey
- FNYLWPVRPXGIIP-UHFFFAOYSA-N
- CAS 데이터베이스
- 396-01-0(CAS DataBase Reference)
- IARC
- 2B (Vol. 108) 2016
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,T,F | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/37/38-36/38-23/25-39/23/24/25-23/24/25-11 | ||
안전지침서 | 26-36/37/39-45-33-24-16-7-36/37 | ||
유엔번호(UN No.) | 2811 | ||
WGK 독일 | 3 | ||
RTECS 번호 | UO3470000 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 2933997500 | ||
유해 물질 데이터 | 396-01-0(Hazardous Substances Data) | ||
기존화학 물질 | KE-28438 |
트리암테렌 C화학적 특성, 용도, 생산
용도
Triamterene은 이핵 성 질소족 방향족 인 푸 테리 딘 골격을 갖는 유기 화학 물질입니다. 이 약은 칼륨 보존 이뇨제 군의 약으로 사용됩니다. Triamteren은 신장을 통해 나트륨 배설을 촉진하여 이뇨 작용을합니다. 나트륨은 수화물 껍질에 물을 결합 시키므로 물이 분비됩니다. 후기 말초 세뇨관 내강과 수집 튜브에 대한 영향으로 - 삼중 생산의 마지막 부분 - 삼중 체는 칼륨을 체내에 보유합니다.개요
Triamterene is an inhibitor of the epithelial sodium channel (ENaC; IC50 = 4.5 μM for the rat channel). In vivo, triamterene (0.5-32 mg/animal) enhances sodium secretion and decreases potassium secretion in adrenalectomized rats. Formulations containing triamterene have been used in the treatment of edema. This product is also available as an analytical reference standard .화학적 성질
Yellow Solid용도
Triamterene is a potassium-sparing diuretic ie, it inhibits the urinary excretion of potassiumBiological Functions
Triamterene (Dyrenium) results in changes in urinary electrolyte patterns that are qualitatively similar to those produced by spironolactone. The mechanism by which this agents bring about the alterations in electrolyte loss, however, is quite different. Triamterene produces this effects whether or not aldosterone or any other mineralocorticoid is present. The action of this drug is clearly unrelated to endogenous mineralocorticoid activity, and this drug is effective in adrenalectomized patients.일반 설명
Odorless yellow powder or crystalline solid. Melting point 316°C. Almost tasteless at first and with a slightly bitter aftertaste. Acidified solutions give a blue fluorescence. Used as a diuretic drug.공기와 물의 반응
Sensitive to light; slowly oxidized upon exposure to air. Insoluble in water.반응 프로필
2,4,7-Triamino-6-phenylpteridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.화재위험
Flash point data for 2,4,7-Triamino-6-phenylpteridine are not available; however, 2,4,7-Triamino-6-phenylpteridine is probably combustible.Mechanism of action
Triamterene is a pyrazine derivative that inhibits reabsorption of sodium ions without increasing excretion of potassium ions. It exhibits the same approximate effect as spironolactone; however, it does not competitively bind with aldosterone receptors. Its action does not have an effect on secretion of aldosterone or its antagonists, which are a result of direct action on renal tubules.This potassium sparing diuretic causes a moderate increase in excretion of sodium and bicarbonate ions in urine, and it raises excretion of potassium and ammonia ions. It has little effect on urine volume.
Clinical Use
Triamterene can be used in the treatment of congestive heart failure, cirrhosis, and the edema caused by secondary hyperaldosteronism. It is frequently used in combination with other diuretics except spironolactone. Amiloride, but not triamterene, possesses antihypertensive effects that can add to those of the thiazides. These K+-sparing diuretics have low efficacy when used alone, since only a small amount of total Na reabsorption occurs at more distal sites of the nephron.These compounds are used primarily in combination with other diuretics, such as the thiazides and loop diuretics, to prevent or correct hypokalemia. The availability of fixed-dose mixtures of thiazides with nonsteroidal K+-sparing compounds has proved a rational form of drug therapy. Both triamterene and amiloride are available alone or in combination with hydrochlorothiazide.
부작용
Because the actions of triamterene and amiloride are independent of plasma aldosterone levels, their prolonged administration is likely to result in hyperkalemia. Both amiloride and triamterene are contraindicated in patients with hyperkalemia.Triamterene should not be given to patients with impaired renal function. Potassium intake must be reduced, especially in outpatients.A folic acid deficiency has been reported to occur occasionally following the use of triamterene.트리암테렌 준비 용품 및 원자재
원자재
phenylacetonitrile
2,4,6-트리아미노피리미딘
나트륨 에톡시드
에틸렌디아민사초산
에틸 사이아노아세테이트
페닐아세토나이트릴
5-Nitroso-2,4,6-triaminopyrimidine
푸로세미드
준비 용품
트리암테렌 공급 업체
글로벌( 213)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 |
xie@china-sinoway.com | China | 992 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales02@airuikechemical.com | China | 994 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8823 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
트리암테렌 관련 검색:
β-에스트라디올 트리암테렌
Amiloride hydrochloride
Trimethoprim
Bumetanide
Entacapone
Rivaroxaban
Carvedilol
Clarithromycin
Glibenclamide
Docetaxel
TRIAMTERENE-D5
2,4-Diamino-6-(p-methoxyphenyl)pteridine hydrochloride
N,N',N''-(6-Phenyl-2,4,7-pteridinetriyl)tris-acetamide
BIBW 22
P-HYDROXY TRIAMTERENE SULFATE
4-hydroxytriamterene
propyl 5-[4-(2,4,7-triaminopteridin-6-yl)phenoxy]pentanoate