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푸로세미드

푸로세미드
푸로세미드 구조식 이미지
카스 번호:
54-31-9
한글명:
푸로세미드
동의어(한글):
푸로세미드
상품명:
Furosemide
동의어(영문):
ERIS;Furix;Lazax;fusid;lasex;lasix;laxur;salix;"mita";franyl
CBNumber:
CB2445739
분자식:
C12H11ClN2O5S
포뮬러 무게:
330.74
MOL 파일:
54-31-9.mol

푸로세미드 속성

녹는점
220 °C (dec.) (lit.)
끓는 점
582.1±60.0 °C(Predicted)
밀도
1.606
굴절률
1.6580 (estimate)
인화점
11 °C
저장 조건
2-8°C
용해도
Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute solutions of alkali hydroxides.
물리적 상태
powder
산도 계수 (pKa)
pKa 3.8 (Uncertain)
수용성
Soluble in acetone, DMF or methanol. Slightly soluble in water
Merck
14,4309
안정성
Stable, but light sensitive, air sensitive and hygroscopic. Incompatible with strong oxidizing agents.
InChIKey
ZZUFCTLCJUWOSV-UHFFFAOYSA-N
CAS 데이터베이스
54-31-9(CAS DataBase Reference)
IARC
3 (Vol. 50) 1990
EPA
Furosemide (54-31-9)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T,F,Xi
위험 카페고리 넘버 61-39/23/24/25-23/24/25-11-36/37/38
안전지침서 7-16-36/37-45-53-36/37/39-22-36-26
유엔번호(UN No.) UN 1230 3/PG 2
WGK 독일 3
RTECS 번호 CB2625000
HS 번호 2935904000
유해 물질 데이터 54-31-9(Hazardous Substances Data)
독성 LD50 orally in female, male rats: 2600, 2820 mg/kg (Goldenthal)
기존화학 물질 KE-01596
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H303 삼키면 유해할 수 있음 급성 독성 물질 - 경구 구분 5 P312
H360 태아 또는 생식능력에 손상을 일으킬 수 있음 생식독성 물질 구분 1A, 1B 위험
H370 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴(노출되어도 특정 표적장기 독성을 일으키지 않는다는 결정적인 노출경로가 있다면 노출경로를 기재) 특정 표적장기 독성 - 1회 노출 구분 1 위험 P260, P264, P270, P307+P311, P321,P405, P501
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P202 모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P311 의료기관(의사)의 진찰을 받으시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405 밀봉하여 저장하시오.

푸로세미드 MSDS


4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid

푸로세미드 C화학적 특성, 용도, 생산

화학적 성질

white to light yellow crystal powde

Originator

Lasix,Hoechst,W. Germany,1964

용도

diuretic, antihypertensive

용도

Furosemide inhibits ion co-transport in the kidney. Furosemide is used as a diuretic.

용도

This compound belongs to the aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.

용도

An inhibitor of NKCC and a GABAA receptor antagonist.

정의

A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration and anti-hypertensive agent.

Manufacturing Process

10.8 grams of 3-sulfamyl-4,6-dichlorobenzoic acid (0.04 mol) and 11.7 grams of furfurylamine (0.12 mol) are heated in 30 cc of diethyleneglycoldimethylether for 6 hours under reflux. When pouring the reaction mixture into 300 cc of 1 N hydrochloric acid, the reaction product is immediately separated off in the form of crystals. The light-yellow crude product is purified by dissolving it in 100 cc of warm 1 N sodium bicarbonate solution, precipitation by means of hydrochloric acid and subsequent recrystallization from ethanol/water, with addition of charcoal. Colorless prisms are obtained which decompose at 206°C while adopting a brown coloration, and with evolution of gas.

상표명

Lasix (Sanofi Aventis).

Therapeutic Function

Diuretic

일반 설명

Odorless white to slightly yellow crystalline powder. A diuretic drug. Almost tasteless.

공기와 물의 반응

Light sensitive. Air sensitive. Slightly soluble in water.

반응 프로필

Furosemide may undergo hydrolysis at sufficiently low pH. The pH of aqueous solutions should be maintained in the basic range to prevent hydrolysis. Alcohol has been shown to improve the stability of Furosemide. Incompatible with strong oxidizing agents .

위험도

Poison; moderately toxic; teratogen; questionable carcinogen; mutagen.

화재위험

Flash point data for Furosemide are not available; however, Furosemide is probably combustible.

생물학적 활성

Loop diuretic that inhibits the Na + /2Cl - /K + (NKCC) cotransporter. Also acts as a non-competitive antagonist at GABA A receptors with ~ 100-fold greater selectivity for α 6-containing receptors than α 1-containing receptors.

Mechanism of action

Furosemide is a highly effective and quick-acting diuretic whose action, like all of the examined loop diuretics, is associated with blocking reabsorption of ions in the ascending bend of Henle’s loop. It is used for edema syndrome of various origins, edema of the lungs and brain, chronic renal insufficiency, some forms of hypertonic crises, and poisoning by barbiturates and other compounds excreted mainly with urine.

Clinical Use

Furosemide has a saluretic effect 8- to 10-fold that of the thiazide diuretics; however, it has a shorter duration of action (~6–8 hours). Furosemide causes a marked excretion of sodium, chloride, potassium, calcium, magnesium, and bicarbonate ions, with as much as 25% of the filtered load of sodium excreted in response to initial treatment. It is effective for the treatment of edemas connected with cardiac, hepatic, and renal sites. Because it lowers the blood pressure similar to the thiazide derivatives, one of its uses is in the treatment of hypertension.

부작용

Clinical toxicity of furosemide and other loop diuretics primarily involves abnormalities of fluid and electrolyte balance. As with the thiazide diuretics, hypokalemia is an important adverse effect that can be prevented or treated with potassium supplements or coadministration of potassium-sparing diuretics. Increased calcium ion excretion can be a problem for postmenopausal osteopenic women, and furosemide generally should not be used in these individuals. Hyperuricemia, glucose intolerance, increased serum lipid levels, ototoxicity, and gastrointestinal side effects might be observed as well. Hypersensitivity reactions also are possible with furosemide (a sulfonamide-based drug), and cross-reactivity with other sulfonamide containing drugs is possible.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by intravenous route: change in the sensitivity of the ear to sound, tinnitus, unspecified effects on the heart, constriction of the arteries, a decrease in urine volume, interstitial nephritis, metabolic alkalosis, pulse rate decrease, fall in blood pressure. Ingestion can damage the liver. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cl-, NOx, and SOx.

Chemical Synthesis

Furosemide, 4-chloro-N-furfuryl-5-sulfamoylanthranylic acid (21.4.11), is synthesized in a relatively simple manner from 2,4-dichlorobenzoic acid, which is converted into 5-aminosulfonyl-4,6-dichlorobenzoic acid (21.4.10) during subsequent reaction with chlorosulfonic acid and ammonia. Reacting this with furfurylamine gives furosemide (21.4.11) .

Veterinary Drugs and Treatments

Furosemide is used for its diuretic activity in all species. It is used in small animals for the treatment of congestive cardiomyopathy, pulmonary edema, hypercalcuric nephropathy, uremia, as adjunctive therapy in hyperkalemia and, occasionally, as an antihypertensive agent. In cattle, it is approved for use for the treatment of post-parturient udder edema. It has been used to help prevent or reduce epistaxis (exercise-induced pulmonary hemorrhage; EIPH) in racehorses.

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