4-AMINO-1,8-NAPHTHALIMIDE
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4-AMINO-1,8-NAPHTHALIMIDE 속성
- 녹는점
- 360 °C
- 끓는 점
- 352.04°C (rough estimate)
- 밀도
- 1.105 g/mL at 25 °C(lit.)
- 증기압
- 0Pa at 25℃
- 굴절률
- 1.6000 (estimate)
- 저장 조건
- -20°C
- 용해도
- DMSO에 용해됨
- 물리적 상태
- 주황색 고체.
- 산도 계수 (pKa)
- 9.53±0.20(Predicted)
- 수용성
- 354mg/L at 25℃
- LogP
- 1.08
- CAS 데이터베이스
- 1742-95-6
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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4-AMINO-1,8-NAPHTHALIMIDE C화학적 특성, 용도, 생산
개요
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC50 = 180 nM). It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation. 4-ANI is used to study the role of PARP activity in various cell systems.화학적 성질
orange amorphous powder용도
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC50 = 180 nM). It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation. 4-ANI is used to study the role of PARP activity in various cell systems.효소 저해제
This PARP inhibitor (FW = 212.21 g/mol) is a strong inhibitor of NAD:ADP-ribosyltransferase or poly(ADP-ribose) polymerase (IC50 = 0.18 μM). In addition, 4-Amino-1,8-naphthalimide is a radiation sensitizer at non-toxic and low concentrations.4-AMINO-1,8-NAPHTHALIMIDE 준비 용품 및 원자재
원자재
준비 용품
4-AMINO-1,8-NAPHTHALIMIDE 공급 업체
글로벌( 74)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10248 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | CHINA | 52867 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 49999 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131981 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006608290; 18621169109 |
market03@meryer.com | China | 40241 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15848 | 69 |
4-AMINO-1,8-NAPHTHALIMIDE 관련 검색:
4-Amino-N-2,4-xylyl-1,8-naphthalimide
4-AMINO-1,8-NAPHTHALIMIDE
LUCIFER YELLOW CH DILITHIUM SALT
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1,8-Naphthalimide
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6-(4-ACETAMIDO-1 8-NAPHTHALAMIDO) HEXANO
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H-LYS(DABSYL)-SER-GLU-VAL-ASN-LEU-ASP-ALA-GLU-PHE-ARG-GLN-LUCIFER YELLOW
LUCIFER YELLOW CH DIPOTASSIUM SALT
LUCIFER YELLOW VS DILITHIUM SALT
4-AMINO-1,8-NAPHTHALIMIDE
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4-(DI-TERT-BUTOXYCARBONYL)AMINO-1,8 –NAPHTHALIMIDE
6-AMINO-2-(3-HYDROXY-PHENYL)-BENZO[DE]ISOQUINOLINE-1,3-DIONE
4-(6-NITRO-1,3-DIOXO-1H,3H-BENZO[DE]ISOQUINOLIN-2-YL)-BENZOIC ACID
6-AMINO-2-(2-HYDROXY-ETHYL)-1,3-DIOXO-2,3-DIHYDRO-1H-BENZO[DE]ISOQUINOLINE-5-SULFONIC ACID
2-(4-AMINOPHENYL)-6-NITRO-1H-BENZO[DE]ISOQUINOLINE-1,3(2H)-DIONE