Alkaloid naturally occurring in the d-form. Shows GABA antagonist activity.
일반 설명
Bicuculline is a convulsant alkaloid. It was originally isolated from the plant Dicentra cucullaria.
생물학적 활성
Classical GABA A antagonist.
Safety Profile
A poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofNOx.
Purification Methods
It crystallises from CHCl3/MeOH as plates. The crystals melt at 177o, then solidify and re-melt at 193-195o [Manske Canad J Research 21B 13 1943]. It is soluble in CHCl3, *C6H6, EtOAc but sparingly soluble in EtOH, MeOH and Et2O. [Stereochem: Blaha et al. Collect Czech Chem Commun 29 2328 1964, Snatzke et al. Tetrahedron 25 5059 1969, Pharmcol: Curtis et al. Nature 266 1222 1970, Beilstein 27 III/IV 1900].