2-Butyl-4-chloro-5-formylimidazole
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2-Butyl-4-chloro-5-formylimidazole 속성
- 녹는점
- 97-100 °C(lit.)
- 끓는 점
- 384.1±22.0 °C(Predicted)
- 밀도
- 1.240
- 증기압
- 0.001Pa at 25℃
- 저장 조건
- Inert atmosphere,2-8°C
- 용해도
- 물에 약간 용해됨
- 물리적 상태
- Powder to crystal
- 산도 계수 (pKa)
- 8.87±0.10(Predicted)
- 색상
- 연한 노란색에서 갈색까지
- 수용성
- 약간 용해됨
- InChIKey
- JLVIHQCWASNXCK-UHFFFAOYSA-N
- LogP
- 2.5 at 25℃ and pH7.1
- 표면장력
- 58.3mN/m at 1.2g/L and 20℃
- CAS 데이터베이스
- 83857-96-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi,N | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 43-51/53 | ||
| 안전지침서 | 24-37-61 | ||
| 유엔번호(UN No.) | UN 3077 9/PG 3 | ||
| WGK 독일 | 2 | ||
| 위험 등급 | IRRITANT | ||
| 포장분류 | III | ||
| HS 번호 | 29339900 |
2-Butyl-4-chloro-5-formylimidazole C화학적 특성, 용도, 생산
개요
2-Butyl-4-chloro-5-formylimidazole is an API intermediate used as an intermediate for the anti-hypertensive drug Chlosartan. It can be used in the chemical manufacture of many APIs and advanced intermediates. With the help of this chemical, a number of other chemicals can be manufactured that have further applications in industries such as Losartan manufacturing.화학적 성질
2-Butyl-4-chloro-5-formylimidazole is Yellow Solid용도
2-Butyl-4-chloro-5-formylimidazole is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists주요 응용
2-Butyl-4-chloro-1H-imidazole-5-carboxaldehyde (Losartan EP Impurity D) is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists. Losartan USP Related Compound A.Synthesis
2-Butyl-4-chloro-5-formylimidazole was synthesised as follows: Performing condensation reaction of pentamidine hydrochloride with glyoxal and controlling the pH value of the system in the range of 6.0-7.5; after the reaction terminates, arousing dehydration reaction of the compound of formula III, thereby obtaining 2-butyl-1H-imidazole-5(4H)-ketone; and finally, reacting 2-butyl-1H-imidazole-5(4H)-ketone with N,N-dimethylformamide in the presence of phosphorus oxychloride, thereby obtaining 2-butyl-4-chloro-5-formylimidazole.저장
2-Butyl-4-chloro-5-formylimidazole is soluble in DMF, DMSO, Ethanol and Methanol.2-Butyl-4-chloro-5-formylimidazole 준비 용품 및 원자재
원자재
준비 용품
4’-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1,1’-Biphenyl]-2-carbonitrile
(2-BUTYL-5-CHLORO-1H-IMIDAZOL-4-YL)METHANOL
EPROSARTAN
N-(4-Bromobenzyl)-2-butyl-4-chloro-1H-imidazole-5-carboxyaldehyde
2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde
2-Butyl-4-chloro-5-formylimidazole 공급 업체
글로벌( 544)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23556 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 |
sales@nbinno.com | CHINA | 925 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 |
sales@finerchem.com | China | 2967 | 58 |