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메티마졸

메티마졸
메티마졸 구조식 이미지
카스 번호:
60-56-0
한글명:
메티마졸
동의어(한글):
메티마졸;1,3-다이하이드로-1-메틸-2H-이미다졸-2-싸이온;티아마졸;1-메틸-1,3-다이하이드로이미다졸-2-싸이온;1-메틸-1H-이미다졸-2-싸이올;1-메틸-2-머캅토-1H-이미다졸;1-메틸-2-머캅토이미다졸;1-메틸-3H-이미다졸-2-싸이온;1-메틸-4-이미다졸린-2-싸이온;1-메틸이미다졸-2(3H)-싸이온;2H-이미다졸-2-싸이온, 1,3-다이하이드로-1-메틸-;2-머캅토-1-메틸이미다졸
상품명:
Methimazole
동의어(영문):
Basolan;Metizol;METAZOLE;Favistan;Metazolo;Tapuzole;TAPAZOLE;Frentirox;Mercazole;Merkastan
CBNumber:
CB9220870
분자식:
C4H6N2S
포뮬러 무게:
114.17
MOL 파일:
60-56-0.mol

메티마졸 속성

녹는점
144-147 °C (lit.)
끓는 점
280 °C
밀도
1.176 (estimate)
굴절률
1.5000 (estimate)
인화점
280°C
저장 조건
2-8°C
용해도
200g/l
물리적 상태
Crystalline Powder
산도 계수 (pKa)
12.37±0.50(Predicted)
색상
White to slightly cream or pale buff
수용성
soluble
Merck
14,5971
BRN
108646
CAS 데이터베이스
60-56-0(CAS DataBase Reference)
IARC
3 (Vol. 79) 2001
NIST
Methimazole(60-56-0)
EPA
Methimazole (60-56-0)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 43-62-63-22
안전지침서 26-27-36-45-36/37
WGK 독일 3
RTECS 번호 NI8615000
TSCA Yes
HS 번호 29332990
유해 물질 데이터 60-56-0(Hazardous Substances Data)
기존화학 물질 2009-3-3732
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H303 삼키면 유해할 수 있음 급성 독성 물질 - 경구 구분 5 P312
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H361 태아 또는 생식능력에 손상을 일으킬 것으로 의심됨 생식독성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405 밀봉하여 저장하시오.
NFPA 704
1
1 0

메티마졸 MSDS


Methimazole

메티마졸 C화학적 특성, 용도, 생산

화학적 성질

White Solid

Originator

Favistan ,Asta

용도

Methimazole also directly disrupts thyroxine and triiodothyronin sysnthesis in the thyroid gland, and it is used for the same indications as propylthiouracil and methylthiouracil to treat hyperfunctioning thyroid glands in patients with Basedow’s disease.

용도

2-Mercapto-1-methylimidazole was employed as hydrophobic charge-induction chromatography ligand for antibody purification. It was also used in preparation of nitrile functionalized methimazole-based room temperature ionic liquids.

용도

Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid

Manufacturing Process

2 Methods of preparation of thiamazole:
1. To 2,2-diethoxyethylamine methylisothiocyanate was added and mixed after then 1-(2,2-diethoxy-ethyl)-3-methylthiourea was obtained.
The reaction of the 1-(2,2-diethoxyethyl)-3-methylthiourea with sulfuric acid yield thiamazole.
2. 1,1-Diethoxyethane was treated by bromine in the presence CaCO3 and 2- bromo-1,1-diethoxyethane was obtained.
Then to the 2-bromo-1,1-diethoxyethane methylamine was added, mixed and reaction mixture was heated to 120°-130°C in autoclave. As the result (2,2- diethoxyethyl)methylamine was obtained.
(2,2-Diethoxyethyl)methylamine reacted with potassium thiocyanate in the presence of hydrochloric acid and give the thiamazole, yellow crystallic precipitate, melting point 144°-147°C.

상표명

Tapazole (Jones); Tapazole (King) .

Therapeutic Function

Thyroid inhibitor

일반 설명

Methimazole, 1-methylimidazole-2-thiol (Tapazole), occurs as a white to off-white, crystallinepowder with a characteristic odor and is freely soluble inwater. A 2% aqueous solution has a pH of 6.7 to 6.9. It shouldbe packaged in well-closed, light-resistant containers.

Biochem/physiol Actions

Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine.

Clinical Use

Methimazole is indicated in the treatment of hyperthyroidism.It is more potent than propylthiouracil. The side effectsare similar to those of propylthiouracil. As with otherantithyroid drugs, patients using this drug should be undermedical supervision. Also, like the other antithyroid drugs,methimazole is most effective if the total daily dose is subdividedand given at 8-hour intervals.

Safety Profile

Poison by subcutaneous route. Moderately toxic by ingestion and intraperitoneal routes. Human teratogenic effects. An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Human mutation data reported. An antithyroid drug. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also MERCAPTANS.

Chemical Synthesis

Methimazole, 1-methyl-2-imidazolthiol (25.2.5), is synthesized by reacting aminoacetic aldehyde diethylacetal with methylisothiocyanate and subsequent hydrolysis of the acetal group of the resulting disubstituted urea derivative 25.2.4 by a solution of sulfuric acid, during which a simultaneous cyclization reaction takes place, forming the imidazole ring of the desired methimazole .

Veterinary Drugs and Treatments

Methimazole is considered by most clinicians to be the agent of choice when using drugs to treat feline hyperthyroidism. Propylthiouracil has significantly higher incidences of adverse reactions when compared to methimazole and is rarely used today. Transdermal methimazole (in PLO gel; 2.5 mg twice daily) has been used with some therapeutic success in cats that do not tolerate oral dosing. Efficacy may require four or more weeks to detect. Studies are ongoing.
Methimazole appears to be useful for the prophylactic prevention of cisplatin induced nephrotoxicity in dogs.

Purification Methods

Crystallise it from EtOH. UV: at 251nm (H2O), 260nm (EtOH) and 267nm (CHCl3). [Lawson max & Morley J Chem Soc 1103 1956, Beilstein 24 H 17, 24 III/IV 61.]

메티마졸 준비 용품 및 원자재

원자재

준비 용품


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