메티마졸
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메티마졸 속성
- 녹는점
- 144-147 °C (lit.)
- 끓는 점
- 280 °C
- 밀도
- 1.176 (estimate)
- 굴절률
- 1.5000 (estimate)
- 인화점
- 280°C
- 저장 조건
- 2-8°C
- 용해도
- 200g/L
- 물리적 상태
- 결정성 분말
- 산도 계수 (pKa)
- 12.37±0.50(Predicted)
- 색상
- 흰색에서 약간 크림색 또는 창백한 담황색
- 수용성
- 녹는
- Merck
- 14,5971
- BRN
- 108646
- CAS 데이터베이스
- 60-56-0(CAS DataBase Reference)
- NIST
- Methimazole(60-56-0)
- IARC
- 3 (Vol. 79) 2001
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 43-62-63-22 | ||
안전지침서 | 26-27-36-45-36/37 | ||
WGK 독일 | 3 | ||
RTECS 번호 | NI8615000 | ||
TSCA | Yes | ||
HS 번호 | 29332990 | ||
유해 물질 데이터 | 60-56-0(Hazardous Substances Data) | ||
기존화학 물질 | 2009-3-3732 |
메티마졸 C화학적 특성, 용도, 생산
화학적 성질
White Solid용도
Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid일반 설명
Methimazole, 1-methylimidazole-2-thiol (Tapazole), occurs as a white to off-white, crystallinepowder with a characteristic odor and is freely soluble inwater. A 2% aqueous solution has a pH of 6.7 to 6.9. It shouldbe packaged in well-closed, light-resistant containers.Clinical Use
Methimazole is indicated in the treatment of hyperthyroidism.It is more potent than propylthiouracil. The side effectsare similar to those of propylthiouracil. As with otherantithyroid drugs, patients using this drug should be undermedical supervision. Also, like the other antithyroid drugs,methimazole is most effective if the total daily dose is subdividedand given at 8-hour intervals.Safety Profile
Poison by subcutaneous route. Moderately toxic by ingestion and intraperitoneal routes. Human teratogenic effects. An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Human mutation data reported. An antithyroid drug. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also MERCAPTANS.Purification Methods
Crystallise it from EtOH. UV: at 251nm (H2O), 260nm (EtOH) and 267nm (CHCl3). [Lawson max & Morley J Chem Soc 1103 1956, Beilstein 24 H 17, 24 III/IV 61.]메티마졸 준비 용품 및 원자재
원자재
준비 용품
메티마졸 공급 업체
글로벌( 514)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Henan Suikang Pharmaceutical Co.,Ltd. | +86-18239973690 +86-18239973690 |
sales@suikangpharm.com | China | 311 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 |
info@tnjchem.com | China | 2989 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Shanghai Arbor Chemical Co., Ltd. | 021-60451682 |
act@arborchemical.com | CHINA | 906 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
메티마졸 관련 검색:
이미다졸 1-메틸이미다졸 2-에틸헥실 10-에틸-4-[[2-[(2-에틸헥실)옥시]-2-옥소에틸]티오]-4-메틸-7- 옥소-8-옥사-3,5-다이티아-4-주석테트라테카노산염 티오글리콜산 2-메틸이미다졸 에탄디티올 멜라티온 2-머캅토에탄올 메티마졸
N-(Trimethylsilyl)imidazole
2-MERCAPTOIMIDAZOLE
2-MERCAPTO-1-METHYLIMIDAZOLE
1-Methyl-2-imidazolidinethione
5-(HYDROXYMETHYL)-2-MERCAPTO-1-METHYLIMIDAZOLE,2-Mercapto-1-methylimidazole-5-methanol
Methimazole-D3
THIAMAZOL IMPURITY C
2-MERCAPTO-4-METHYLIMIDAZOLE
Methimazole Glucuronide,Methimazole Thio-b-D-glucuronide,Methimazole Glucuronid,Methimazole Thio--D-glucuronide