Itraconazole
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Itraconazole 속성
- 녹는점
- 166°C
- 끓는 점
- 850.0±75.0 °C(Predicted)
- 알파
- -0.1~+0.1°(D/20℃)(c=10,CH2Cl2)
- 밀도
- 1.27 g/cm3
- 인화점
- >110°(230°F)
- 저장 조건
- 2-8°C
- 용해도
- 클로로포름: 50mg/mL, 투명, 무색
- 산도 계수 (pKa)
- 3.7(at 25℃)
- 물리적 상태
- 백색분말
- 색상
- 하얀색
- 수용성
- 물에 불용성. 50 mg/ml의 클로로포름에 용해됩니다. 에탄올이나 메탄올에 약간 용해됨
- Merck
- 14,5245
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- InChIKey
- VHVPQPYKVGDNFY-UHFFFAOYSA-N
- CAS 데이터베이스
- 84625-61-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi,Xn,T,F | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38-36/38-22-39/23/24/25-23/24/25-11 | ||
안전지침서 | 22-26-36-45-36/37-16 | ||
유엔번호(UN No.) | UN 3286 8(6.1)(3) / PGII | ||
WGK 독일 | 3 | ||
RTECS 번호 | XZ5481000 | ||
HS 번호 | 2934990002 | ||
유해 물질 데이터 | 84625-61-6(Hazardous Substances Data) | ||
독성 | LD50 (14 day) in mice, rats, dogs (mg/kg): >320, >320, >200 orally (Van Cauteren) |
Itraconazole C화학적 특성, 용도, 생산
개요
Itraconazole is an orally-active triazole antifungal indicated for use in the treatment of dermal, vaginal and systemic mycoses. In immunocompromised and AIDS patients, itraconazole has been shown to significantly reduce the incidence of relapses of cryptococcal meningitis.화학적 성질
Off-White Crystalline Solid용도
Itraconazole is a triazole antifungal agent. It is used to inhibit cytochrome P-450-dependent enzymes and ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis, and aspergillosis. It?s different formulations are used to study Candida strains in murine invasive infections. It has been used to study proliferative changes of the forestomach mucosa in alloxan-induced diabetic rats..Indications
Itraconazole (Sporanox) is effective in the treatment of histoplasmosis, blastomycosis, candidiasis, and dermatophyte infection. Its efficacy in the treatment of tinea capitis in children is equal to griseofulvin, and it is usually better tolerated (21). It is metabolized by the cytochrome P-450 system and may increase the levels ofwarfarin, cyclosporine, and digoxin among others. Its use is contraindicated with certain medications.Itraconazole (Sporanox) is a triazole antifungal that is related to the imidazole ketoconazole. Similar to ketoconazole, it interferes with ergosterol synthesis and cell membrane integrity. It is clinically active against dimorphic fungi, yeast, dermatophytes, Blastomycetes, histoplasmosis, sporotrichosis, and Aspergillus. Itraconazole is a potent inhibitor of the cytochrome P450 3A enzyme system, which may elevate blood levels of other drugs metabolized by this system if taken concomitantly. Itraconazole levels may decrease in patients who are concurrently taking rifampin, phenobarbital, or phenytoin. Cyclosporine, felodipine, digoxin, warfarin, and oral hypoglycemic levels may increase when given in conjunction with itraconazole. Itraconazole, like ketoconazole, is contraindicated in patients taking cisapride. Itraconazole may induce torsades de pointes, ventricular arrhythmias, and congestive heart failure.
Antimicrobial activity
The spectrum includes dermatophytes, dimorphic fungi (Blast. dermatitidis, Coccidioides spp., Hist. capsulatum, Paracocc. brasiliensis, Penicillium marneffei and Spor. schenckii), molds (including Aspergillus spp.), dematiaceous fungi and yeasts (Candida spp. and Cryptococcus spp.).원료
This is uncommon, but fluconazole-resistant C. albicans and C. glabrata are often cross-resistant to itraconazole. There are reports of itraconazole-resistant strains of A. fumigatus.일반 설명
Itraconazole is an antifungal drug prescribed for oral or intravenous treatment of fungal infections. The drug is sold under trade names such as Sporanoxor Onmel?. This Certified Spiking Solution? is suitable as starting material for calibrators, controls, or linearity standards for clinical and diagnostic testing or therapeutic drug monitoring of itraconazole in patient blood, serum, or plasma samples by LC-MS/MS or HPLC.Pharmaceutical Applications
A synthetic dioxolane triazole available for oral or parenteral administration.Clinical Use
AspergillosisSystemic mycoses with dimorphic fungi (blastomycosis, coccidioidomycosis, histoplasmosis, paracoccidioidomycosis, penicilliosis) Subcutaneous mycoses (chromoblastomycosis, sporotrichosis)
Mucosal and cutaneous candidosis.
Dermatophytosis
Phaeohyphomycosis
Pityriasis versicolor
부작용
Unwanted effects are more common with oral solution than with capsules, and are more severe. They include nausea, abdominal discomfort, dyspepsia, diarrhea, headache, pruritus and skin rash. Rare side effects include Stevens–Johnson syndrome, transient abnormalities of liver enzymes, reversible idiosyncratic hepatitis and hypokalemia.Intravenous itraconazole has been associated with congestive heart failure. Neither intravenous nor oral itraconazole should be used to treat infections in patients with evidence of ventricular dysfunction unless the expected benefit clearly exceeds the risk. Patients with risk factors for congestive heart failure should be treated with caution and their condition monitored.
Itraconazole 준비 용품 및 원자재
원자재
P-클로로니트로벤젠
4-(1-아세틸피페라진-4-일)페놀
Chloroformate
2',4'-Dichloroacetophenone
m-디클로로벨젠
케토코나졸
2-브로모부탄
메틸이소부틸케톤
수소
브롬화수소
탄산 칼륨
아나스트로졸
수소화나트륨
1-(4-메톡시페닐)피페라진디하이드로클로라이드
준비 용품
Itraconazole 공급 업체
글로벌( 812)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12446 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5987 | 58 |
Shandong Huisheng Import & Export Co., Ltd. | +86-13176845580 +86-13176845580 |
da@zhongda-biotech.com | China | 248 | 58 |
Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 |
justine@zhongda-biotech.com | China | 300 | 58 |
Anhui Zhongda Biotechnology Co., Ltd | +8615689548120 |
linda@zhongda-biotech.com | China | 204 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 994 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales02@sdzhonghuimaterial.com | China | 983 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1143 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Itraconazole 관련 검색:
디클로로메틸페닐실란 디페닐디클로로실란 이산화셀레늄 1.4-다이옥세인
DIOXOPROMETHAZINE HCL
Cis-2-(2,4-DichloroPhenyl)-2(Ih-I,2,4-Triazol-L-Yl-Methy>>-L,3-Dioxolan-4-MethanolMethaneSulfonate,Itraconazole,
HYDROXY ITRACONAZOLE
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione
Ipamorelin
1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one
IXABEPILONE
KETO ITRACONAZOLE
(+-) 1-BROMO-2-METHYLBUTANE 95
trans-Itraconazole
N-Desalkyl Itraconazole
Itraconazole Impurity 34
Butyl Itraconazole
2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-