P-클로로니트로벤젠
|
|
P-클로로니트로벤젠 속성
- 녹는점
- 80-83 °C(lit.)
- 끓는 점
- 242 °C(lit.)
- 밀도
- 1.298 g/mL at 25 °C(lit.)
- 증기 밀도
- 5.4 (vs air)
- 증기압
- 0.09 mm Hg ( 25 °C)
- 굴절률
- 1.5376 (estimate)
- 인화점
- >230 °F
- 용해도
- 아세톤과 알코올에 용해됨(Weast, 1986)
- 물리적 상태
- 결정 또는 플레이크
- 색상
- 노란색
- 수용성
- 불용성
- Merck
- 14,2151
- BRN
- 508691
- Henry's Law Constant
- 4.90 x 10-6 atm?m3/mol at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)
- 노출 한도
- Potential occupational carcinogen. NIOSH REL: IDLH 100; OSHA PEL: TWA 1.
- 안정성
- 안정적인. 타기 쉬운. 강한 산화제, 수산화물과 호환되지 않습니다. 메탄올의 나트륨메톡사이드와 격렬하게 반응함.
- InChIKey
- CZGCEKJOLUNIFY-UHFFFAOYSA-N
- CAS 데이터베이스
- 100-00-5(CAS DataBase Reference)
- IARC
- 2B (Vol. 65, 123) 2020
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,N | ||
---|---|---|---|
위험 카페고리 넘버 | 23/24/25-40-48/20/21/22-51/53-68 | ||
안전지침서 | 28-36/37-45-61-28A | ||
유엔번호(UN No.) | UN 1578 6.1/PG 2 | ||
WGK 독일 | 2 | ||
RTECS 번호 | CZ1050000 | ||
자연 발화 온도 | 500 °F | ||
위험 참고 사항 | Very Toxic | ||
TSCA | Yes | ||
위험 등급 | 6.1 | ||
포장분류 | II | ||
HS 번호 | 29049085 | ||
유해 물질 데이터 | 100-00-5(Hazardous Substances Data) | ||
독성 | LD50 (skin) for rats 16 gm/kg (quoted, RTECS, 1985). | ||
IDLA | 100 mg/m3 | ||
기존화학 물질 | KE-05780 |
P-클로로니트로벤젠 C화학적 특성, 용도, 생산
물리적 성질
p-Nitrochlorobenzene is a yellow crystalline solid with a sweet odor.화학적 성질
4-Chloronitrobenzene is a light yellow monoclinic prisms crystallizes, which are insoluble in water and very soluble in toluene, ether, acetone, or hot ethanol. It is incompatible with strong oxidizers and alkalis. It is extensively used in different industries as an intermediate in the manufacture of dyes, rubber, and agricultural chemicals.용도
4-Nitrochlorobenzene is an important intermediate in the manufacture of azo dyes and sulfide dyes, the drugs finasteride and paracetamol, the pesticide herbicide, etc. It is also the raw material of rubber antioxidant 4010.정의
ChEBI: 4-Chloronitrobenzene is a C-nitro compound.일반 설명
Light yellow crystalline solid. Density 1.520 g / cm3. Melting point 83°C. Sweet odor. Very toxic by inhalation, ingestion, and skin absorption. p-Chloronitrobenzene is extensively used in different industries as an intermediate in the manufacture of dyes, rubber, and agricultural chemicals. It is incompatible with strong oxidisers and alkalis.공기와 물의 반응
Insoluble in water.반응 프로필
4-Chloronitrobenzene reacts with oxidizing agents. Reacts violently and finally explosively when added to a solution of sodium methoxide in methanol. . Unstable when heated.위험도
A questionable carcinogen. Very toxic by inhalation and ingestion. Absorbed via skin. Combustible. Methemoglobinemia.건강위험
Repeated exposure to high levels of p-chloronitrobenzene causes adverse health effects. The symptoms of toxicity include, but are not limited to, anoxia, unpleasant taste, anemia, methemoglobinemia, hematuria (blood in the urine), spleen, kidney, bone marrow changes, and reproductive effects. The target organs of p-chloronitrobenzene poisoning have been identifi ed as the blood, liver, kidneys, cardiovascular system, spleen, bone marrow, and reproductive system.화재위험
4-Chloronitrobenzene is combustible.Safety Profile
Confirmed carcinogen with experimental carcinogenic data. A poison by ingestion. Experimental reproductive effects. Mutation data reported. Flammable liquid when exposed to heat, sparks, or flame. May explode on heating. Potentially violent reaction with sodium methoxide. When heated to decomDosition it emits very toxic fumes of NOx and Cl-. See also other chloronitrobenzene entries and NITRO COMPOUNDS OF AROMATIC HYDROCARBONS.잠재적 노출
p-Nitrochlorobenzene (PNCB) is used as an intermediate in pesticide (parathion) manufacture, drug (phenacetin and acetaminophen) manufacture; and in dye making; rubber and antioxidant manufacture.Carcinogenicity
No increase in tumor incidence was seen in rats fed up to 1000 ppm in the diet for 2 years; in mice, results were equivocal, with high-dose animals showing an increase in vascular tumors and low-dose males showing an increase in liver tumors.6 The IARC has determined that there is inadequate evidence in experimental animals and humans for the carcinogenicity of chlorobenzenes.7운송 방법
UN1578 Chloronitrobenzenes, solid or liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.Purification Methods
Crystallise the nitrobenzene from 95% EtOH (charcoal) and sublime it in vacuo. [Emmons JAm Chem Soc 76 3470 1954, Newman & Forrest J Am Chem Soc 69 1221 1947, Beilstein 5 IV 723.]비 호환성
A strong oxidizer. Reacts violently with oxidizers, combustibles, alkalis, sodium methoxide; and reducing materials.폐기물 처리
Incineration (816℃, 0.5 second for primary combustion; 1204℃, 1.0 second for secondary combustion). The formation of elemental chlorine can be prevented through injection of steam or methane into the combustion process. nitrogen oxides may be abated through the use of thermal or catalytic devices.P-클로로니트로벤젠 준비 용품 및 원자재
원자재
준비 용품
4-나이트로아니솔
[5-(프로필시오)-1H-벤지마이다졸-2-일]카르바믹산 메틸 에스테르; 알벤다졸
Sodium 2-chloro-5-nitrobenzenesulfonate
p-펜네티딘
프로파닐
2- 아미노 -5- 클로로 벤조
노르플록사신
p-플루오로미트로벤젠
Disperse Blue 301
7-chloro-1,3-dihydro-5-phenyl-2-oxo-2H-1,4-benzodiazepin-3-yl acetate
4-NITROPHENYL PHENYL ETHER
4 니트로페네톨
디우론
클로르나이트로펜
4-(1-Acetylpiperazin-4-yl)phenol
Demoxepam
Itraconazole
4-디아조디페닐아민 바이황산염
VARIAMINE BLUE B DIAZONIUM SALT
BIS(4-NITROPHENYL) SULFIDE
3,4-디클로로아닐린
4-니트로페놀소다염(2수화물)
알프라졸람
아닐로포스
2-CHLORO-5-NITROBENZENESULFONIC ACID
설파구아니딘
6-CHLORO-2-(CHLOROMETHYL)-3-OXIDO-4-PHENYL-QUINAZOLINE
5-CHLORO-3-PHENYLANTHRANIL
4-(4-Methylpiperazino)aniline
M-니트로클로로벤젠
3,4-디클로로나이트로벤젠
4-[(4-methoxyphenyl)amino]benzenediazonium
나이트로펜(나이트로펜)
4-Aminodiphenylamine
Estazolam
파라-아미노디페닐아민
4-ISOTHIOCYANATO-4'-NITRODIPHENYL ETHER
1-METHYL-4-(4-NITROPHENYL)PIPERAZINE
1-(4-ISOCYANATOPHENYL)-4-METHYLPIPERAZINE
4-플루오로페놀