DOXEPIN
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DOXEPIN 속성
- 녹는점
- 187-189°C
- 끓는 점
- bp0.03 154-157°; bp0.2 260-270°
- 밀도
- 1.0594 (rough estimate)
- 굴절률
- 1.5000 (estimate)
- 저장 조건
- Sealed in dry,2-8°C
- 산도 계수 (pKa)
- 9.40±0.28(Predicted)
- 수용성
- 31.57mg/L(25℃)
안전
| 위험품 표기 | T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 25 | ||
| 안전지침서 | 36/37/39-45 | ||
| 유해 물질 데이터 | 1668-19-5(Hazardous Substances Data) | ||
| 독성 | LD50 in mice, rats (mg/kg): 26, 16 i.v.; 79, 182 i.p.; 135, 147 orally (Ribbentrop, Schaumann) |
DOXEPIN C화학적 특성, 용도, 생산
용도
Used clinically to treat anxiety and depression. Antidepressant정의
ChEBI: A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.World Health Organization (WHO)
Doxepin, a tricyclic antidepressant was introduced in 1964 for the management of endogenous depression. Much of the adverse effects are caused by its antimuscarinic actions. These include dry mouth, cardiac arrhythmias, central nervous system disturbances, blood disorders and risk of suicide. The risk of suicide and dangers related to overdosage led the Norwegian Medicines Control Authority to put the higher strength formulation under prescribing restriction in 1992. The risk of death following overdosage is apparently higher for products containing tricyclic compounds as compared with nontricyclic products.생물학적 활성
Highly potent H 1 histamine receptor antagonist (K d = 310 pM) and tricyclic antidepressant. Also binds to the H 4 histamine receptor (pK i = 6.79).색상 색인 번호
This benzoxepin tricylcic drug has antidepressant, anticholinergic, antiitching, and antihistamine properties. After oral use, it has been developed as a topical antiitching agent. Allergic contact dermatitis is not infrequent.DOXEPIN 준비 용품 및 원자재
원자재
1,3-디브로모프로판
브로모벤젠
hydracide
1-브로모프로판
트리페닐포스핀
디메틸아민
10-Chloro-10, 11-dihydro-dibenz(b,f)thiepin
부틸리튬
브롬화수소
준비 용품
DOXEPIN 공급 업체
글로벌( 35)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29220 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 |
sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15848 | 69 |
| LGM Pharma | 1-(800)-881-8210 |
inquiries@lgmpharma.com | United States | 2127 | 70 |
| BOC Sciences | 1-631-485-4226; 16314854226 |
info@bocsci.com | United States | 14059 | 65 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 |
waley188@sohu.com | China | 12338 | 58 |
| EMMX Biotechnology LLC | 888-539-0666 |
info@emmx.com | United States | 8449 | 60 |