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Acebutolol

Acebutolol 구조식 이미지
카스 번호:
37517-30-9
상품명:
Acebutolol
동의어(영문):
Prent;Sectral;ACEBUTOLOL;Acebutololum;Acetobutolol;dl-Acebutolol;Acebutolo HCl;AcebutololDiscontinued. See: A123800;3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide;5'-Butyramido-2'-(2-hydroxy-3-isopropylaminopropoxy)acetophenone
CBNumber:
CB5393651
분자식:
C18H28N2O4
포뮬러 무게:
336.43
MOL 파일:
37517-30-9.mol

Acebutolol 속성

녹는점
119-123°C
끓는 점
472.9°C (rough estimate)
밀도
1.1748 (rough estimate)
굴절률
1.5700 (estimate)
저장 조건
-20°C Freezer
산도 계수 (pKa)
pKa 9.40 (Uncertain)
수용성
259 mg/L
CAS 데이터베이스
37517-30-9(CAS DataBase Reference)
NIST
Acebutolol(37517-30-9)

안전

Acebutolol C화학적 특성, 용도, 생산

화학적 성질

Crystalline Solid

용도

Cardioselective ?adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II)

용도

Cardioselective β-adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).

정의

ChEBI: An ether that is the 2-acetyl-4-(butanoylamino)phenyl ether of the primary hydroxy group of 3-(propan-2-ylamino)propane-1,2-diol.

상표명

Sectral (Dr. Reddy’s).

일반 설명

Acebutolol is one of the very few β-blockers whosemetabolite plays a significant role in its pharmacological actions.This drug is absorbed well from the gastrointestinaltract, but it undergoes extensive first-pass metabolic conversionto diacetolol by hydrolytic conversion of the amidegroup to the amine, followed by acetylation of the amine. After oral administration, plasma levels of diacetololare higher than those of acebutolol. Diacetolol is also aselective β1-blocker with partial agonistic activity; it has littlemembrane-stabilizing activity. It has a longer half-life (8–12hours) than the parent drug and is excreted by the kidneys.

Clinical Use

Acebutolol (Sectral) is a cardioselective 1-adrenoceptor blocking agent that also has some minor membrane stabilizing effects on the action potential. Acebutolol is effective in the management of the patient with essential hypertension, angina pectoris, and ventricular arrhythmias. Antiarrhythmic effects are observed with the patient both at rest and taking exercise.

부작용

Adverse effects include bradycardia, gastrointestinal upset, dizziness, and headache.

신진 대사

About half of an orally administered dose of acebutolol (Sectral) is absorbed. Approximately 25% of the drug is bound to plasma proteins, and its plasma halflife is about 4 hours.Metabolism of acebutolol produces a metabolite with -blocking activity whose half-life is 10 hours.

주의 사항

Acebutolol should not be administered in cardiogenic shock, uncontrolled heart failure, or severe bradycardia or to patients with known hypersensitivity to the drug.

Acebutolol 준비 용품 및 원자재

원자재

준비 용품


Acebutolol 공급 업체

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