Travoprost
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Travoprost 속성
- 알파
- D20 +14.6° (c = 1.0 in methylene chloride)
- 끓는 점
- 584.8±50.0 °C(Predicted)
- 밀도
- 1.245±0.06 g/cm3(Predicted)
- 인화점
- 17 °C
- 저장 조건
- Sealed in dry,Store in freezer, under -20°C
- 용해도
- 디클로로메탄(소량으로 용해, 초음파 처리함), 클로로포름(소량으로 용해), 메탄올(소량으로 용해)
- 물리적 상태
- 에탄올 용액에 용해됨
- 산도 계수 (pKa)
- 13.43±0.20(Predicted)
- 색상
- 무색~연한 베이지
- BCS Class
- 2
- 안정성
- 감광성
- InChIKey
- MKPLKVHSHYCHOC-AHTXBMBWSA-N
- CAS 데이터베이스
- 157283-68-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | F,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 11-36/37/38 | ||
안전지침서 | 16-26-36-7 | ||
유엔번호(UN No.) | UN 1170 3/PG 2 | ||
WGK 독일 | 1 | ||
HS 번호 | 2937500000 |
Travoprost C화학적 특성, 용도, 생산
개요
Travoprost was launched in the US as Travatan?, an ophthalmic solution (0.004%) administered topically for the treatment of elevated intraocular hypertension (lOP) through open-angle glaucoma, a common optic neuropathy and a leading cause of blindness. Travoprost is the isopropyl ester of (+)-fluprostenol, a new prostaglandin derivative belonging to the PGF2α, analog class. This compound can be prepared in 8 steps from a bicyclic lactone aldehyde by a Wittig alkylidenation followed, after 2 ketonic reductions, by a lactol opening to prostenoic acid while protecting and deprotecting appropriately. Travoprost is a full agonist of FP receptors with a greater affinity than PGF2α, (K1 = 52 nM). Pharmacologic studies in rabbits treated daily for a week demonstrated a significant increase of the microvascular optic nerve head blood flow without significant alterations in the systemic flow. In several placebo-controlled clinical studies with hundreds of patients suffering from open-angle glaucoma or ocular hypertension, travoprost (1 to 4 pm daily) dose-dependently reduced lOP (by about 30% at 4 pm); it was shown equal or superior to latanoprost, another prostaglandin analog (5 pm daily) or the adrenergic ~-blocker timolol (500 pm bid). In addition, travoprost was safe and well tolerated with a low incidence of conjunctival hyperaemia.화학적 성질
Colorless Oil용도
Travoprost is a selective FP prostaglandin receptor agonist used to treat glaucoma (1,2).정의
ChEBI: The isopropyl ester of prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophth lmic solutions of travoprost are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. It is a pro-drug; the isopropyl ester group is hydrolysed by esterases in the co nea to the biologically active free acid, fluprostenol.일반 설명
Travoprost (Travatan and Travatan-Z) is supplied asa 2.5- or 5.0-mL sterile 0.004% ophthalmic solution in a4.0- or 7.5-mL size container. Travoprost is claimed to bethe most potent and FP-specific analog in this product category. Cautions and side effects are similar to those givenpreviously.Travoprost 준비 용품 및 원자재
원자재
준비 용품
Travoprost 공급 업체
글로벌( 403)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Wuhan Quanjinci New Material Co.,Ltd. | +8615271838296 |
kyra@quanjinci.com | China | 1534 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales02@sdzhonghuimaterial.com | China | 983 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9355 | 55 |
Shanghai finete Pharmaceutical Co., Ltd. | +86-18221039705 |
CHINA | 139 | 55 | |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 |
stella@zetchem.com | China | 2136 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14335 | 58 |