Travoprost
- CAS No.
- 157283-68-6
- Chemical Name:
- Travoprost
- Synonyms
- Trovoprost;Trivo;FLU-IPR;AL 6221;Travatan;ravopros;Travaprost;TRAVOPROST;Trivoprost;Travoprostt
- CBNumber:
- CB5703458
- Molecular Formula:
- C26H35F3O6
- Molecular Weight:
- 500.55
- MDL Number:
- MFCD03411995
- MOL File:
- 157283-68-6.mol
alpha | D20 +14.6° (c = 1.0 in methylene chloride) |
---|---|
Boiling point | 584.8±50.0 °C(Predicted) |
Density | 1.245±0.06 g/cm3(Predicted) |
Flash point | 17 °C |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | Dichloromethane (Sparingly, Sonicated), Chloroform (Sparingy), Methanol (Sparing |
form | ethanol solution |
pka | 13.43±0.20(Predicted) |
color | Colourless to Light Beige |
BCS Class | 2 |
Stability | Light Sensitive |
InChIKey | MKPLKVHSHYCHOC-AHTXBMBWSA-N |
CAS DataBase Reference | 157283-68-6(CAS DataBase Reference) |
FDA UNII | WJ68R08KX9 |
ATC code | S01EE04 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS02,GHS07 |
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Signal word | Danger | |||||||||
Hazard statements | H225-H319 | |||||||||
Precautionary statements | P210-P233-P240-P241-P242-P305+P351+P338 | |||||||||
Hazard Codes | F,Xi | |||||||||
Risk Statements | 11-36/37/38 | |||||||||
Safety Statements | 16-26-36-7 | |||||||||
RIDADR | UN 1170 3/PG 2 | |||||||||
WGK Germany | 1 | |||||||||
HS Code | 2937500000 | |||||||||
NFPA 704 |
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Travoprost price More Price(34)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | PHR1622 | Travoprost Pharmaceutical Secondary Standard; Certified Reference Material | 157283-68-6 | 3mL | $173 | 2024-03-01 | Buy |
Sigma-Aldrich | 1673001 | Travoprost | 157283-68-6 | 3ml | $436 | 2024-03-01 | Buy |
Cayman Chemical | 16769 | Fluprostenol isopropyl ester ≥98% | 157283-68-6 | 1mg | $70 | 2024-03-01 | Buy |
Cayman Chemical | 16769 | Fluprostenol isopropyl ester ≥98% | 157283-68-6 | 5mg | $308 | 2024-03-01 | Buy |
Cayman Chemical | 16769 | Fluprostenol isopropyl ester ≥98% | 157283-68-6 | 10mg | $545 | 2024-03-01 | Buy |
Travoprost Chemical Properties,Uses,Production
Description
Travoprost was launched in the US as Travatan?, an ophthalmic solution (0.004%) administered topically for the treatment of elevated intraocular hypertension (lOP) through open-angle glaucoma, a common optic neuropathy and a leading cause of blindness. Travoprost is the isopropyl ester of (+)-fluprostenol, a new prostaglandin derivative belonging to the PGF2α, analog class. This compound can be prepared in 8 steps from a bicyclic lactone aldehyde by a Wittig alkylidenation followed, after 2 ketonic reductions, by a lactol opening to prostenoic acid while protecting and deprotecting appropriately. Travoprost is a full agonist of FP receptors with a greater affinity than PGF2α, (K1 = 52 nM). Pharmacologic studies in rabbits treated daily for a week demonstrated a significant increase of the microvascular optic nerve head blood flow without significant alterations in the systemic flow. In several placebo-controlled clinical studies with hundreds of patients suffering from open-angle glaucoma or ocular hypertension, travoprost (1 to 4 pm daily) dose-dependently reduced lOP (by about 30% at 4 pm); it was shown equal or superior to latanoprost, another prostaglandin analog (5 pm daily) or the adrenergic ~-blocker timolol (500 pm bid). In addition, travoprost was safe and well tolerated with a low incidence of conjunctival hyperaemia.
Chemical Properties
Colorless Oil
Originator
Alcon (US)
Uses
Travoprost is a selective FP prostaglandin receptor agonist used to treat glaucoma (1,2).
Uses
treatment conditions arising from excess uric acid, eg chronic gout
Uses
Selective FP prostaglandin receptor agonist. Isopropyl ester of (+)-fluprostenol. Antiglaucoma
Definition
ChEBI: The isopropyl ester of prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophth lmic solutions of travoprost are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. It is a pro-drug; the isopropyl ester group is hydrolysed by esterases in the co nea to the biologically active free acid, fluprostenol.
brand name
Travatan
General Description
Travoprost (Travatan and Travatan-Z) is supplied asa 2.5- or 5.0-mL sterile 0.004% ophthalmic solution in a4.0- or 7.5-mL size container. Travoprost is claimed to bethe most potent and FP-specific analog in this product category. Cautions and side effects are similar to those givenpreviously.
Travoprost Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Wuhan Quanjinci New Material Co.,Ltd. | +8615271838296 | kyra@quanjinci.com | China | 1534 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 | sales02@sdzhonghuimaterial.com | China | 983 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9357 | 55 |
Shanghai finete Pharmaceutical Co., Ltd. | +86-18221039705 | CHINA | 139 | 55 | |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14335 | 58 |
View Lastest Price from Travoprost manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-20 | Travoprost
157283-68-6
|
US $0.00 / Kg/Bag | 2Kg/Bag | USP32 | 20 tons | Sinoway Industrial co., ltd. | ||
2024-09-18 | Travoprost
157283-68-6
|
US $0.00 / g | 1g | 96%-102% | 100G | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2024-09-18 | Travoprost
157283-68-6
|
US $10.00 / gram | 10gram | 99% | 50000 kilograms | Wuhan Senwayer Century Chemical Co.,Ltd |
- Travoprost
157283-68-6
- US $0.00 / Kg/Bag
- USP32
- Sinoway Industrial co., ltd.
- Travoprost
157283-68-6
- US $0.00 / g
- 96%-102%
- WUHAN FORTUNA CHEMICAL CO., LTD
- Travoprost
157283-68-6
- US $10.00 / gram
- 99%
- Wuhan Senwayer Century Chemical Co.,Ltd
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