1,2-Bis(chlorodimethylsilyl)ethane
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1,2-Bis(chlorodimethylsilyl)ethane 속성
- 녹는점
- 35-38 °C (lit.)
- 끓는 점
- 198 °C/734 mmHg (lit.)
- 밀도
- 0.99
- 인화점
- 155 °F
- 저장 조건
- Inert atmosphere,Room Temperature
- 물리적 상태
- 저융점 고체
- 색상
- 투명한
- 수용성
- 물과 반응합니다.
- 감도
- Moisture Sensitive
- Hydrolytic Sensitivity
- 8: reacts rapidly with moisture, water, protic solvents
- BRN
- 1920141
- InChIKey
- VGQOKOYKFDUPPJ-UHFFFAOYSA-N
- CAS 데이터베이스
- 13528-93-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | C | ||
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위험 카페고리 넘버 | 34-10 | ||
안전지침서 | 26-28-36/37/39-45-16 | ||
유엔번호(UN No.) | UN 3261 8/PG 2 | ||
WGK 독일 | 3 | ||
F 고인화성물질 | 10-21 | ||
TSCA | Yes | ||
위험 등급 | 8 | ||
포장분류 | III | ||
HS 번호 | 29319000 |
1,2-Bis(chlorodimethylsilyl)ethane C화학적 특성, 용도, 생산
화학적 성질
transparent low melting solid물리적 성질
mp 36–41°C; bp 198°C/734 mmHg.용도
1,2-Bis(chlorodimethylsilyl)ethane can be used as a reagent for the protection of primary amines as their tetramethyldisilylazacyclopentane or Stabase adducts; used in combination with zinc to form organozinc carbenoids; electrophilic silylating reagent.Protection of Primary Amines.
Few protecting groups exist for the N,N-diprotection of primary amines. The tetramethyldisilylazacyclopentane or Stabase adduct (3) is particularly attractive for this purpose due to its ease of preparation, base stability and facile removal. This cyclic disilane is easily prepared (eq 1) from the commercially available title reagent (1).For primary amines with pKa values between 10 and 11, typical reaction conditions involve the treatment of a dichloromethane solution of the amine with (1) in the presence of two equivalents of triethylamine at room temperature. Subsequent workup with aqueous dihydrogen phosphate provides (3) in excellent yields.1 Stabase adducts are quite stable to strongly basic conditions such as n-butyllithium and s-butyllithium (at ?25°C), lithium diisopropylamide, and Grignard reagents making it a superb candidate for use in the alkylation of substrates bearing a primary amine. For example, protected amino acid derivatives are easily alkylated (eq 2).After formation of the lithium enolate of the protected ethyl glycinate (4) under standard conditions, exposure to various alkyl halides or aldehydes yields alkylation products such as (5).
1,2-Bis(chlorodimethylsilyl)ethane 준비 용품 및 원자재
원자재
준비 용품
1,2-Bis(chlorodimethylsilyl)ethane 공급 업체
글로벌( 218)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18628 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
Zjartschem | +86-571 87238903 |
jocelynpan@zjarts.com | CHINA | 993 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 |
info@konochemical.com | China | 2995 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
Hubei Co-Formula Material Tech Co., Ltd. | +86-27-84459282 |
sales@cfmats.com | CHINA | 882 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 |
sale04@alfachem.cn | China | 13363 | 58 |
1,2-Bis(chlorodimethylsilyl)ethane 관련 검색:
아이소뷰틸렌 옥사이드 클로로디메틸비닐실란 염화에틸 에탄 터트-뷰틸클로로다이메틸실란 헥사플루오로에테인(헥사플루오르에탄) 시메티콘 (DOW CORNING) 1,1,2,2-테트라클로로에틸렌 디실란 트리메틸클로로실란 트라이메틸실레인 디메틸클로로실란
DIMETHYLTHEXYLSILYL CHLORIDE
(2-BROMOETHOXY)-TERT-BUTYLDIMETHYLSILANE
1-Cyclohexenyloxytrimethylsilane
ETHYLDIMETHYLCHLOROSILANE
ETHYLDIMETHYLSILANE
METHYLETHYLCHLOROSILANE