Triprolidine hydrochloride
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Triprolidine hydrochloride 속성
- 녹는점
- 115-120°C
- 저장 조건
- 2-8°C
- 용해도
- 알코올: 용매 1.5에 용해1
- 색상
- 흰색에서 황백색까지
- 수용성
- 20°C에서 >=10g/100mL
- Merck
- 13,9817
- 안정성
- 안정적이지만 빛에 변색됩니다. 강한 산화제와 호환되지 않습니다.
- LogP
- 4.223 (est)
- CAS 데이터베이스
- 6138-79-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-36/37/38 | ||
| 안전지침서 | 26-36 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | UT7658000 | ||
| HS 번호 | 2933399090 |
| 그림문자(GHS): |
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| 신호 어: | Warning | |||||||||||||||||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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Triprolidine hydrochloride C화학적 특성, 용도, 생산
화학적 성질
TRIPROLIDINE HYDROCHLORIDE is a white, crystalline powder.용도
TRIPROLIDINE HYDROCHLORIDE is used as bulk pharmaceutical (antihistaminic). Product Data Sheet정의
TRIPROLIDINE HYDROCHLORIDE is a hydrate that is the monohydrate form of triprolidine hydrochloride. A sedating antihistamine, it is used for the symptomatic relief of uticaria, rhinitis, and various pruritic skin disorders.일반 설명
Triprolidine hydrochloride,(E)-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine monohydrochloridemonohydrate (Actidil), is a white crystalline powder with a slight, but unpleasant, odor. It is soluble inwater and in alcohol, and its solutions are alkaline to litmus.The antihistaminic activity is confined mainly to the geometricisomer in which the pyrrolidinomethyl group is transto the 2-pyridyl group. Pharmacological studies confirm thehigh activity of triprolidine and the superiority of (E) overcorresponding (Z) isomers as H1-antihistamines. At guineapig ileum sites, the affinity of triprolidine for H-receptorswas more than 1,000 times the affinity of its (Z) diasteromer.The relative potency of triprolidine is of the same orderas that of dexchlorpheniramine. The peak effect occursabout 3.5 hours after oral administration, and the duration ofeffect is about 12 hours.
공기와 물의 반응
Water soluble.반응 프로필
Triprolidine hydrochloride discolors on exposure to light.건강위험
SYMPTOMS: Symptoms of exposure to Triprolidine hydrochloride may include depression to stimulation of the central nervous system, dry mouth, fixed dilated pupils, flushing, hallucinations, convulsions, urinary retention, cardiac arrhythmias and coma. Other symptoms may include excitability, drowsiness, nervousness, dizziness, high fever and sleeplessness. It can also cause sedation. It may also cause local anesthesia, dryness of the throat and nose and abdominal pain with vomiting or diarrhea.화재위험
Flash point data for Triprolidine hydrochloride are not available; however, Triprolidine hydrochloride is probably combustible.생물학적 활성
Potent H 1 receptor antagonist.Triprolidine hydrochloride 준비 용품 및 원자재
원자재
준비 용품
Triprolidine hydrochloride 공급 업체
글로벌( 160)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 |
1056@dideu.com | China | 3581 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 9271 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29118 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 |
info@afinechem.com | CHINA | 15377 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 +86-13986145403 |
info@fortunachem.com | China | 5988 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9339 | 58 |
| CD Chemical Group Limited | +8615986615575 |
info@codchem.com | China | 20356 | 58 |
Triprolidine hydrochloride 관련 검색:
N-메틸-2-피롤리디논 피리딘 세틸피리디늄 염화물 모노수화물 폴리비닐피로리돈 피리딘 하이드로클로라이드 포비돈요오드 메페리딘 수화염화물
CALAMINE
Topotecan hydrochloride
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Triprolidine
Cyproheptadine hydrochloride sesquihydrate
METHYL-2-PYRROLIDONE
ALPHA,P-DIMETHYLSTYRENE
TRANS-TRIPROLIDINE HYDROCHLORIDE
Triprolidine hydrochloride
TRIPOLIDINE
TRIPROLIDINE HYDROCHLORIDE Z-ISOMER (100 MG)