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폴리비닐피로리돈

폴리비닐피로리돈
폴리비닐피로리돈 구조식 이미지
카스 번호:
9003-39-8
한글명:
폴리비닐피로리돈
동의어(한글):
폴리비닐피롤리돈;폴리비닐피로리돈;폴리비닐피로리딘;1-에텐일-2-피롤리디논호모중합물;폴리(1-비닐피롤리디논);포비돈;피브이피;폴리비닐피로리돈(POLYVINYLPYRROLIDONE)
상품명:
Polyvinylpyrrolidone
동의어(영문):
k25;k60;POP;PVP;k115;pvp2;pvp3;pvp4;pvp5;pvp6
CBNumber:
CB4209342
분자식:
CH4
포뮬러 무게:
16.04246
MOL 파일:
9003-39-8.mol

폴리비닐피로리돈 속성

녹는점
~165 °C (dec.)(lit.)
밀도
1,69 g/cm3
저장 조건
Store at RT.
용해도
H2O: soluble100mg/mL
물리적 상태
powder
색상
White to yellow-white
수소이온지수(pH)
3.0-5.0
수용성
Soluble in water.
감도
Hygroscopic
Merck
14,7697
안정성
Stable. Incompatible with strong oxidizing agents. Light sensitive. Hygroscopic.
EPA
2-Pyrrolidinone, 1-ethenyl-, homopolymer(9003-39-8)

안전

안전지침서 22-24/25
WGK 독일 1
RTECS 번호 TR8370000
자연 발화 온도 440 °C
TSCA Yes
HS 번호 39059990
유해 물질 데이터 9003-39-8(Hazardous Substances Data)
독성 LD50 orally in Rabbit: > 2000 mg/kg

폴리비닐피로리돈 MSDS


Polyvinylpyrrolidone

폴리비닐피로리돈 C화학적 특성, 용도, 생산

용도

결합제, 모발고정제/정발제, 유화안정제, 피막형성제, 현탁화제(비계면활성)

용도

수용액은 혈액 대용으로 사용
직물 휘니시
모발용 로션과 크림등의 첨가제,분산제,천연수지대용
합성세제의 재오염 방지제

제품 소개

폴리 비닐 피 롤리 돈 (PVP) 흰색 또는 크림 백색 분말, 무취, 비 독성, 비 자극, 쉽게 물, 알코올, 아민 및 기타 여러 유기 용매에 녹입니다. 그것은 유기 용매의 물과 다양한 녹일 수있다.

화학적 성질

Hygroscopic, white or yellowish-white powder or flakes.

화학적 성질

Povidone occurs as a fine, white to creamy-white colored, odorless or almost odorless, hygroscopic powder. Povidones with K-values equal to or lower than 30 are manufactured by spray-drying and occur as spheres. Povidone K-90 and higher K-value povidones are manufactured by drum drying and occur as plates.

용도

suitable for gene delivery

정의

ChEBI: A vinyl polymer composed of repeating -CH2-CR- units where R is a 2-oxopyrrolidin-1-yl group.

생산 방법

Povidone is manufactured by the Reppe process. Acetylene and formaldehyde are reacted in the presence of a highly active copper acetylide catalyst to form butynediol, which is hydrogenated to butanediol and then cyclodehydrogenated to form butyrolactone. Pyrrolidone is produced by reacting butyrolactone with ammonia. This is followed by a vinylation reaction in which pyrrolidone and acetylene are reacted under pressure. The monomer, vinylpyrrolidone, is then polymerized in the presence of a combination of catalysts to produce povidone.

상표명

Kollidon CL (BASF); Kollidon CLM (BASF); Polyplasdone (International Specialty Products);Acu-dyne;Adapettes;Adsorbobase;Adsovbotear;Agent at 717;Albigen a;Aldacol q;Amiorel eritro;Amyderm s;Andrestrac 2-10;Anexa;B 7509;Betaisod;Bridine;Clinidine;Final step;Frepp/sepp;Ganex p 804;Ga-pvp-101;Gyno-bidex;Isoplasma;Jodoplex;K 115;Kollidon 17;Kollidon 25;Kollidon 30;Kollidon 90;Kollidon ce 50/50;Kollidon k 25;Kollidon k 30;Luviskol k 17;Luviskol k 25;Luviskol k 30;Luviskol k 90;Luvisteol;Medicort;Molycu;Mundidon;Neojodin;Oftan flurekain;Peragal st;Periston-n-toxobin;Pevidine;Plasmadone;Plasmoid;Plassint;Podiodine;Polyclar at;Polyclar h;Polyclar l;Polyplasdone xl;Polyvidone-escupient;Polyvinyl pyrrolidone;Povadyne;Povidone k 29-32;Pvp 50;Pvp0;Pvp-k 15;Pvp-k 25;Pvp-k 30;Pvp-k 60;Pvp-k 90;Pvp-macrose;Pvp-macrox;Rocmuth;Sd 13;Soft-care;Tears plus;Venostasin retard;Vetedine;Yodiplexin.

World Health Organization (WHO)

Polyvidone, a polymer of vinylpyrrolidinone, is an excipient used as a suspending and dispersing agent. Injectable preparations containing polymers with a molecular weight in the order of 12,000 have caused painful local granulomatous lesions. This has led to the withdrawal of polyvidone from such preparations in some countries. Polyvidone was formerly also used as a plasma expander but, because it was sequestered within the liver and spleen, this use has been discontinued. However, it remains widely used as a vehicle for ophthalmic preparations, and as the major component of artificial tears.

일반 설명

White powder. Compatible with a wide range of hydrophilic and hydrophobic resins.

공기와 물의 반응

Hygroscopic. Water soluble.

반응 프로필

Polyvinylpyrrolidone is a polymeric material and probably has low reactivity. Polyvinylpyrrolidone reacts as a weak base.

위험도

Questionable carcinogen.

건강위험

SYMPTOMS: Polyvinylpyrrolidone may cause interstitial fibrosis in the lungs. Lesions regress when patient is no longer being exposed to the compound.

화재위험

Flash point data for Polyvinylpyrrolidone are not available, but Polyvinylpyrrolidone is probably non-flammable.

Pharmaceutical Applications

Although povidone is used in a variety of pharmaceutical formulations, it is primarily used in solid-dosage forms. In tableting, povidone solutions are used as binders in wet-granulation processes.Povidone is also added to powder blends in the dry form and granulated in situ by the addition of water, alcohol, or hydroalcoholic solutions. Povidone is used as a solubilizer in oral and parenteral formulations, and has been shown to enhance dissolution of poorly soluble drugs from solid-dosage forms. Povidone solutions may also be used as coating agents or as binders when coating active pharmaceutical ingredients on a support such as sugar beads.
Povidone is additionally used as a suspending, stabilizing, or viscosity-increasing agent in a number of topical and oral suspensions and solutions. The solubility of a number of poorly soluble active drugs may be increased by mixing with povidone.
Special grades of pyrogen-free povidone are available and have been used in parenteral formulations;

색상 색인 번호

Polyvinylpyrrolidone is widely used as is in cosmetics such as hair care products and in medical products. It acts as iodophor in iodine-polyvinylpyrrolidone. PVP is an irritant and has been claimed as the allergen in some cases of dermatitis from iodine-polyvinylpyrrolidone (although iodine is more likely the hapten). It may cause type I contact urticaria or anaphylaxis.

Safety Profile

Mtldly toxic by intraperitoneal and intravenous routes. Questionable carcinogen. When heated to decomposition it emits toxic fumes of NOx.

Safety

Povidone has been used in pharmaceutical formulations for many years, being first used in the 1940s as a plasma expander, although it has now been superseded for this purpose by dextran.
Povidone is widely used as an excipient, particularly in oral tablets and solutions. When consumed orally, povidone may be regarded as essentially nontoxic since it is not absorbed from the gastrointestinal tract or mucous membranes.Povidone additionally has no irritant effect on the skin and causes no sensitization. exists that povidone may accumulate in the organs of the body following intramuscular injection.
A temporary acceptable daily intake for povidone has been set by the WHO at up to 25 mg/kg body-weight.
(mouse, IP): 12 g/kg

저장

Povidone darkens to some extent on heating at 150°C, with a reduction in aqueous solubility. It is stable to a short cycle of heat exposure around 110–130°C; steam sterilization of an aqueous solution does not alter its properties. Aqueous solutions are susceptible to mold growth and consequently require the addition of suitable preservatives.
Povidone may be stored under ordinary conditions without undergoing decomposition or degradation. However, since the powder is hygroscopic, it should be stored in an airtight container in a cool, dry place.

Purification Methods

Purify it by dialysis, and freeze-drying. Also by precipitation from CHCl3 solution by pouring into ether. Dry it in a vacuum over P2O5. For the crosslinked polymer purification is by boiling for 10minutes in 10% HCl and then washing with glass-distilled water until free from Cl ions. Finally, Cl ions are removed more readily by neutralising with KOH and continued washing.

비 호환성

Povidone is compatible in solution with a wide range of inorganic salts, natural and synthetic resins, and other chemicals. It forms molecular adducts in solution with sulfathiazole, sodium salicylate, salicylic acid, phenobarbital, tannin, and other compounds; see Section 18. The efficacy of some preservatives, e.g. thimerosal, may be adversely affected by the formation of complexes with povidone.

Regulatory Status

Accepted for use in Europe as a food additive. Included in the FDA Inactive Ingredients Database (IM and IV injections; ophthalmic preparations; oral capsules, drops, granules, suspensions, and tablets; sublingual tablets; topical and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

폴리비닐피로리돈 준비 용품 및 원자재

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