폴리비닐피로리돈

폴리비닐피로리돈 속성

폴리비닐피로리돈 MSDS

Polyvinylpyrrolidone

폴리비닐피로리돈 C화학적 특성, 용도, 생산

용도

결합제, 모발고정제/정발제, 유화안정제, 피막형성제, 현탁화제(비계면활성)

용도

수용액은 혈액 대용으로 사용
직물 휘니시
모발용 로션과 크림등의 첨가제,분산제,천연수지대용
합성세제의 재오염 방지제

제품 소개

폴리 비닐 피 롤리 돈 (PVP) 흰색 또는 크림 백색 분말, 무취, 비 독성, 비 자극, 쉽게 물, 알코올, 아민 및 기타 여러 유기 용매에 녹입니다. 그것은 유기 용매의 물과 다양한 녹일 수있다.

순도시험

  (1) 액성 : 이 품목 5g을 물에 현탁시켜 100mL로 한 수용액의 pH는 3.0～5.0 이어야 한다.

  (2) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.

  (3) 알데히드 : 이 품목 10g을 정밀히 달아 물 300mL에 녹여 25% 황산 80mL을 가하여 1,000mL 둥근플라스크에서 45분간 환류냉각기에서 추출한다. pH 3.1로 맞춘 1N 히드록실아민염산염 20mL이 있는 100mL에 증류한다. 0.1N 수산화나트륨용액으로 pH 3.1까지 pH 미터로서 적정한다. 따로 같은 방법으로 공시험을 한다[0.2% 이하(알데히드로서)].

0.1N 수산화나트륨용액 = 4.405mg C₂H₄O

  (4) 히드라진 : 이 품목 2.5g을 50mL 원심분리관에 취하고 물 25mL을 가하여 녹인 후 살리실알데히드메탄올용액(1→20) 500μL를 가하여 흔든 후 60℃ 수욕상에서 15분간 가열한다. 이를 식힌 후 톨루엔 2.0mL을 가하여 튜브에 넣고 2분 동안 격렬히 흔든 후 원심분리하여 상층액을 취하여 시험용액으로 한다. 시험용액 10μL와 미리 조제한 살리실알다진 표준용액 10μL를 박층크로마토그래피판에 점적한다. 이때 사용되는 박층크로마토그래피판은 디메틸실란화된 실리카겔이 흡착된 것을 사용하고 이동상은 메탄올․물의 혼액(2 : 1)을 사용하여 3/4 지점까지 전개시키고 풍건하여 365nm 자외선하에서 관찰한다. 이때 시험용액의 반점은 표준용액의 것보다 진하여서는 아니 된다(1ppm 이하).

    살리실알다진 표준용액 : 황산히드라진 300mg을 물 5mL에 녹이고 무수초산 1mL와 방금 제조한 20% 살리실알데히드 이소프로필용액을 가하여 노란색의 침전물이 생길 때까지 방치한다. 이를 메틸클로라이드 15mL로 두 번 추출하고 메틸렌클로라이드용액을 제거하여 완전히 증발건고 시킨다. 따뜻한 톨루엔․메탄올의 혼액(60 : 40)을 가한 후 냉각하여 살리실알다진을 재결정화 시켜 여과하고 진공하에서 건조시킨다. 이의 융점은 213～219℃이며 융점 초기와 말기는 1℃이상 초과하여서는 아니 된다. 이 표준용액 1mL는 톨루엔 9.38μg 함유되어 있다.

  (5) 상대점도 : 이 품목을 건조물로서 약 1g을 정밀히 달아 물 50mL에 녹인 후 100mL로 하여 1시간 동안 정치시켜 여과한 다음 시험용액으로 한다. 미리 깨끗이 세척하고 건조시킨 압베점도계를 수욕상에서 25±0.2℃로 유지시킨 다음 시험용액 10mL를 넣고 10분 동안 점도계와 시험용액을 수욕상에서 가온한 후 시험용액의 상층부가 정확히 윗 표시선 위까지 가도록 모세관을 통하여 부드럽게 흡입한다. 흡입을 완화한 다음 모세관속 시험용액 곡면이 윗 표시선에 도달하였을 때 모세관을 통한 흐름시간 측정을 시작한다. 모세관속 시험용액 곡면이 윗 표시선에서 아래 표시선에 도달할 때까지의 정확한 시간을 측정하며 이 과정을 세 번 반복하여 0.1초 단위로 평균을 계산한다. 만약 반복측정시간의 범위가 0.3초를 넘을 경우 점도계를 깨끗이 세척한 다음 시험용액 10mL로 다시 측정한다. 상대점도는 시험용액의 평균흐름시간을 동일하게 측정한 물의 흐름시간으로 나누어 계산한다[1.188～1.325(분자량 약 40,000), 3.225～5.662(분자량 약 360,000)].

  (6) 모노머 : 이 품목 약 4g을 정밀히 달아 물 30mL을 가하여 공전플라스크에서 녹인 후 초산나트륨 0.5g과 혼합하면서 0.1N 요오드용액으로 적정한다. 요오드의 색이 더 이상 변하지 않을 때 적정액 3.0mL을 가하고 5～10분간 방치한 후 0.1N 치오황산나트륨으로 과잉의 요오드를 적정한다(지시액 : 전분시액). 동량의 0.1N 요오드를 사용하여 공시험을 행한다[1% 이하(비닐피로리돈으로서)].

0.1N 요오드용액 1mL = 5.56mg C₆H₉NO

  (7) 질소 : 이 품목 0.1g을 분해플라스크에 취하여 황산칼륨과 황산동(1 : 1)의 혼합물 1g을 넣고 플라스크에 내벽을 소량의 물로 씻어 내린다. 다시 황산 7mL를 가하여 플라스크를 흔들어 주면서 30% 과산화수소 1mL를 서서히 가하여 내용물이 청색의 투명한 액이 될 때까지 가열하여 분해한다. 분해가 완료되면 식힌 다음 물 20mL를 가한 액을 시험용액으로 하여 질소정량법에 따라 시험할 때, 그 양은 12.2～13.0% 이어야 한다.

확인시험

  (1) 이 품목의 수용액(1→50) 10mL에 1N 염산 20mL과 중크롬산칼륨 5mL을 가할 때, 오렌지색의 침전이 생긴다.

  (2) 이 품목의 수용액(1→50) 5mL에 75mg 질산코발트와 0.3g 치오시안산암모늄을 물 2mL에 녹여 혼합하고 묽은염산으로 산성화시킨다. 이 때 엷은 청색의 침전이 생긴다.

화학적 성질

Hygroscopic, white or yellowish-white powder or flakes.

용도

Polyvinylpyrrolidone is used as an adhesive in glue sticks; an emulsifier and a disintegrant for solution polymerization; an additive to Doro's RNA extraction buffer; as a liquid-phase dispersion enhancing agent in diffusion-ordered spectroscopy (DOSY) NMR and as a thickening agent in tooth whitening gels. It finds use in personal care products like shampoos and toothpastes, in ink for inkjet printers as well as in contact lens solutions. It is used as a food additive and in the wine industry as a fining agent for white wine. It is used as a capping agent to synthesize silver nanowires through a polyol process.

생산 방법

Povidone is manufactured by the Reppe process. Acetylene and formaldehyde are reacted in the presence of a highly active copper acetylide catalyst to form butynediol, which is hydrogenated to butanediol and then cyclodehydrogenated to form butyrolactone. Pyrrolidone is produced by reacting butyrolactone with ammonia. This is followed by a vinylation reaction in which pyrrolidone and acetylene are reacted under pressure. The monomer, vinylpyrrolidone, is then polymerized in the presence of a combination of catalysts to produce povidone.

정의

ChEBI: A vinyl polymer composed of repeating -CH2-CR- units where R is a 2-oxopyrrolidin-1-yl group.

제조 방법

N-Vinylpyrrolidone is prepared from 1,4-butanediol as follows:

N -Vinylpyrrolidone is water-soluble and is usually polymerized in aqueous solution at about 50??C with ammonia and hydrogen peroxide. The polymer is also water-soluble and is isolated by spray-drying. Commercial grades of polyvinylpyrrolidone (PVP) have average molecular weights (Mv) ranging from about 10000 up to 360000.
The largest use of polyvinylpyrrolidone is in cosmetic formulations, especially hair lacquers. In the latter applications, polyvinylpyrrolidone is the preferred film-former on account of good adhesion to hair, lustre of the film and ease of removal on washing. The polymer is also used as a binder in pharmaceutical tablets. Polyvinylpyrrolidone also finds use in the textile industry, particularly in colour stripping operations, where the great affinity of the polymer for dyestuffs is utilized. An interesting application of polyvinylpyrrolidone is in aqueous solution as a blood plasma substitute; such material was extensively used in Germany during the Second World War.

World Health Organization (WHO)

Polyvidone, a polymer of vinylpyrrolidinone, is an excipient used as a suspending and dispersing agent. Injectable preparations containing polymers with a molecular weight in the order of 12,000 have caused painful local granulomatous lesions. This has led to the withdrawal of polyvidone from such preparations in some countries. Polyvidone was formerly also used as a plasma expander but, because it was sequestered within the liver and spleen, this use has been discontinued. However, it remains widely used as a vehicle for ophthalmic preparations, and as the major component of artificial tears.

일반 설명

White powder. Compatible with a wide range of hydrophilic and hydrophobic resins.

공기와 물의 반응

Hygroscopic. Water soluble.

반응 프로필

Polyvinylpyrrolidone is a polymeric material and probably has low reactivity. Polyvinylpyrrolidone reacts as a weak base.

위험도

Questionable carcinogen.

건강위험

SYMPTOMS: Polyvinylpyrrolidone may cause interstitial fibrosis in the lungs. Lesions regress when patient is no longer being exposed to the compound.

화재위험

Flash point data for Polyvinylpyrrolidone are not available, but Polyvinylpyrrolidone is probably non-flammable.

Pharmaceutical Applications

Although povidone is used in a variety of pharmaceutical formulations, it is primarily used in solid-dosage forms. In tableting, povidone solutions are used as binders in wet-granulation processes.Povidone is also added to powder blends in the dry form and granulated in situ by the addition of water, alcohol, or hydroalcoholic solutions. Povidone is used as a solubilizer in oral and parenteral formulations, and has been shown to enhance dissolution of poorly soluble drugs from solid-dosage forms. Povidone solutions may also be used as coating agents or as binders when coating active pharmaceutical ingredients on a support such as sugar beads.
Povidone is additionally used as a suspending, stabilizing, or viscosity-increasing agent in a number of topical and oral suspensions and solutions. The solubility of a number of poorly soluble active drugs may be increased by mixing with povidone.
Special grades of pyrogen-free povidone are available and have been used in parenteral formulations;

색상 색인 번호

Polyvinylpyrrolidone is widely used as is in cosmetics such as hair care products and in medical products. It acts as iodophor in iodine-polyvinylpyrrolidone. PVP is an irritant and has been claimed as the allergen in some cases of dermatitis from iodine-polyvinylpyrrolidone (although iodine is more likely the hapten). It may cause type I contact urticaria or anaphylaxis.

Safety Profile

Mtldly toxic by intraperitoneal and intravenous routes. Questionable carcinogen. When heated to decomposition it emits toxic fumes of NOx.

Safety

Povidone has been used in pharmaceutical formulations for many years, being first used in the 1940s as a plasma expander, although it has now been superseded for this purpose by dextran.
Povidone is widely used as an excipient, particularly in oral tablets and solutions. When consumed orally, povidone may be regarded as essentially nontoxic since it is not absorbed from the gastrointestinal tract or mucous membranes.Povidone additionally has no irritant effect on the skin and causes no sensitization. exists that povidone may accumulate in the organs of the body following intramuscular injection.
A temporary acceptable daily intake for povidone has been set by the WHO at up to 25 mg/kg body-weight.
(mouse, IP): 12 g/kg

저장

Povidone darkens to some extent on heating at 150°C, with a reduction in aqueous solubility. It is stable to a short cycle of heat exposure around 110–130°C; steam sterilization of an aqueous solution does not alter its properties. Aqueous solutions are susceptible to mold growth and consequently require the addition of suitable preservatives.
Povidone may be stored under ordinary conditions without undergoing decomposition or degradation. However, since the powder is hygroscopic, it should be stored in an airtight container in a cool, dry place.

Purification Methods

Purify it by dialysis, and freeze-drying. Also by precipitation from CHCl3 solution by pouring into ether. Dry it in a vacuum over P2O5. For the crosslinked polymer purification is by boiling for 10minutes in 10% HCl and then washing with glass-distilled water until free from Cl ions. Finally, Cl ions are removed more readily by neutralising with KOH and continued washing.

비 호환성

Povidone is compatible in solution with a wide range of inorganic salts, natural and synthetic resins, and other chemicals. It forms molecular adducts in solution with sulfathiazole, sodium salicylate, salicylic acid, phenobarbital, tannin, and other compounds; see Section 18. The efficacy of some preservatives, e.g. thimerosal, may be adversely affected by the formation of complexes with povidone.

Regulatory Status

Accepted for use in Europe as a food additive. Included in the FDA Inactive Ingredients Database (IM and IV injections; ophthalmic preparations; oral capsules, drops, granules, suspensions, and tablets; sublingual tablets; topical and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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공급자	전화	이메일	국가	제품 수	이점
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +86-18949832763	info@tnjchem.com	China	2989	55
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	8349	58
Guangzhou TongYi biochemistry technology Co.,LTD	+8613073028829	mack@tongyon.com	China	2996	58
Hebei Kingfiner Technology Development Co.Ltd	+86-15532196582 +86-15373005021	lisa@yibangte.com	China	2987	58
Hebei Jingbo New Material Technology Co., Ltd	+8619931165850	hbjbtech@163.com	China	1000	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+8617702722807	admin@hbouhuang.com	China	2259	58
Anhui Yiao New Material Technology Co., Ltd	+86-199-55145978 +8619955145978	sales8@anhuiyiao.com	China	253	58
Suzhou Sanyi Polymer Chemical Technology Co., Ltd.	+8615571922873	15571922873@163.com	China	106	58
Zibo Wei Bin Import & Export Trade Co. Ltd.	+86-0533-2091136 +8613864437655	ziboweibinmaoyi@163.com	China	100	58

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