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메페리딘 수화염화물

메페리딘 수화염화물
메페리딘 수화염화물 구조식 이미지
카스 번호:
50-13-5
한글명:
메페리딘 수화염화물
동의어(한글):
메페리딘수화염화물;메페리딘수화염화물;페티딘하이드로클로라이드
상품명:
MEPERIDINE HYDROCHLORIDE
동의어(영문):
s140;algil;dolin;lidol;wy554;dolaren;dolosal;endolat;mepadin;petidin
CBNumber:
CB0251343
분자식:
C15H22ClNO2
포뮬러 무게:
283.79
MOL 파일:
50-13-5.mol

메페리딘 수화염화물 속성

녹는점
186-189°
끓는 점
282°C (rough estimate)
밀도
1.0858 (rough estimate)
굴절률
1.5200 (estimate)
인화점
11 °C
저장 조건
2-8°C
용해도
Very soluble in water, freely soluble in alcohol.
CAS 데이터베이스
50-13-5
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T,F
위험 카페고리 넘버 25-39/23/24/25-23/24/25-11
안전지침서 26-36/37/39-45-36/37-16-7
유엔번호(UN No.) 1544
WGK 독일 3
RTECS 번호 NS5950000
위험 등급 6.1(b)
포장분류 III
HS 번호 2933330000
독성 LD50 orally in rats: 170 mg/kg (Barlow, Lewis)
기존화학 물질 KE-24833
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 P264, P270, P301+P310, P321, P330,P405, P501
예방조치문구:
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.

메페리딘 수화염화물 C화학적 특성, 용도, 생산

화학적 성질

White or almost white, crystalline powder.

용도

Analgesic; sedative; anesthetic. Controlled substance (opiate).

정의

An addictive drug, use by prescription only.

Clinical Use

Meperidine is a μ agonist with approximately one-tenth the potency of morphine after intramuscular dose. Meperidine produces the analgesia, respiratory depression, and euphoria caused by other μ opioid agonists, but it causes less constipation and does not inhibit cough. When given orally, meperidine has 40 to 60% bioavailability because of significant first-pass metabolism. Because of the limited bioavailability, it is one-third as potent after an oral dose compared to a parenteral dose.
Meperidine has received extensive use in obstetrics because of its rapid onset and short duration of action. When it is given intravenously in small (25-mg) doses during delivery, the respiratory depression in the newborn child is minimized. Meperidine is used as an analgesic in a variety of nonobstetric anesthetic procedures. Meperidine is extensively metabolized in the liver, with only 5% of the drug being excreted unchanged. Prolonged dosage of meperidine may cause an accumulation of the metabolite normeperidine. Normeperidine has only weak analgesic activity, but it causes CNS excitation and can initiate grand mal seizures. It is recommended that meperidine be discontinued in any patient who exhibits signs of CNS excitation.
Meperidine has a strong adverse reaction when given to patients receiving a monoamine oxidase inhibitor. This drug interaction has been seen recently in patients with Parkinson's disease taking the monoamine oxidase–selective inhibitor selegiline (Eldepryl).
The elimination half-life of meperidine is 3 to 4 hours, and it can double in patients with liver disease. Acidification of the urine will cause enhanced clearance of meperidine, but there is a lesser effect on the clearance of the toxic metabolite normeperidine.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by parenteral route. Experimental teratogenic effects. Mutation data reported. An analgesic. When heated to decomposition it emits very toxic fumes of HCl and NOx.

메페리딘 수화염화물 준비 용품 및 원자재

원자재

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