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P-아니시딘

P-아니시딘 구조식 이미지

카스 번호:: 104-94-9

한글명:: P-아니시딘

동의어(한글):: p-아니시딘;1-아미노-4-메톡시벤젠;4-메톡시아닐린

상품명:: p-Anisidine

동의어(영문):: 4-METHOXYANILINE;PARA ANISIDINE;P-METHOXYANILINE;4-ANISIDINE;P-AMINOANISOLE;4-Methoxy-phenylamine;p-Anisylamine;4-AMINOANISOLE;4-METHOXY-BENZENAMINE;4-[4-(4-Aminophenyl)phenyl]aniline

CBNumber:: CB6852649

분자식:: C7H9NO

포뮬러 무게:: 123.15

MOL 파일:: 104-94-9.mol

MSDS 파일:: SDS

속성

안전

MSDS

용도

공급 업체 539

P-아니시딘 속성

녹는점: 56-59 °C(lit.)

끓는 점: 240-243 °C(lit.)

밀도: 1.06

증기 밀도: 4.28

증기압: 0.02 hPa (20 °C)

굴절률: 1.5559

인화점: 122 °C

저장 조건: Store below +30°C.

용해도: 21g/L

산도 계수 (pKa): 5.34(at 25℃)

물리적 상태: 수정 같은

색상: 짙은 회색에서 갈색까지

Specific Gravity: 1.07

수소이온지수(pH): 7.7 (1g/l, H2O, 20℃)

수용성: 21g/L(20℃)

Merck: 14,667

BRN: 471556

Henry's Law Constant: (x 10^-8 atm?m³/mol): 6.62 at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)

노출 한도: NIOSH REL: TWA 0.5 mg/m³, IDLH 50 mg/m³; OSHA PEL: TWA 0.5 mg/m³; ACGIH TLV: TWA 0.1 ppm (adopted).

Dielectric constant: 8.8399999999999999

안정성: Hygroscopic, Material Darkens In Storage With No Loss In Purity

LogP: 0.950

CAS 데이터베이스: 104-94-9(CAS DataBase Reference)

NIST: Benzenamine, 4-methoxy-(104-94-9)

IARC: 3 (Vol. 27, Sup 7) 1987

EPA: p-Anisidine (104-94-9)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	T+,N,Xi
위험 카페고리 넘버	45-26/27/28-33-50
안전지침서	53-28-36/37-45-61-28A
유엔번호(UN No.)	UN 2811 6.1/PG 3
WGK 독일	2
RTECS 번호	BZ5450000
F 고인화성물질	8
자연 발화 온도	959 °F
TSCA	Yes
위험 등급	6.1
포장분류	III
HS 번호	29222200
유해 물질 데이터	104-94-9(Hazardous Substances Data)
독성	Acute oral LD₅₀ for rats 1,400 mg/kg, mice 810 mg/kg, rabbits 2,900 mg/kg (quoted, RTECS, 1985).
IDLA	50 mg/m3
기존화학 물질	KE-23212

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H350	암을 일으킬 수 있음 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재)	발암성 물질	구분 1A, 1B	위험
H373	장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킬 수 있음	특정 표적장기 독성 - 반복 노출	구분 2	경고	P260, P314, P501
H400	수생생물에 매우 유독함	수생 환경유해성 물질 - 급성	구분 1	경고	P273, P391, P501

예방조치문구:

P201	사용 전 취급 설명서를 확보하시오.
P202	모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P273	환경으로 배출하지 마시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.

NFPA 704

	1
3		0

P-아니시딘 MSDS

4-Methoxybenzeneamine

P-아니시딘 C화학적 특성, 용도, 생산

화학적 성질

Anisidine exists as ortho-, meta-, and paraisomers. They have characteristic amine (fishy) odors. releases toxic nitrogen oxides when heated to decomposition (Sax and Lewis, 1987).

물리적 성질

Yellow to light brown powder, leaflets, solid or crystals with a characteristic amine or ammonialike odor. soluble in ethanol and ether, slightly soluble in water.

용도

p-Anisidine is used mostly for producing dyes, and some smaller quantities are employed in making pharmaceuticals and liquid crystals.

주요 응용

p-Anisidine is used as a reagent to indicate the secondary stage of the oxidation, it is one of the three possible isomers of the Anisidine or methoxyaniline. The other two isomers are o-Anisidine (2-methoxyaniline) and m-Anisidine (3-methoxyaniline).
The p-anisidine is widely used as an intermediate in the production of numerous azo and triphenylmethane dyes, and pigments. It is also used in the production of pharmaceuticals including the guaiacol expectorant, as an antioxidant for polymercaptan resins, and as a corrosion inhibitor for steel. Apart from the beneficial use of p-anisidine, it is toxic for human beings. The acute exposure may cause skin irritation, whereas the chronic exposure may cause headaches, vertigo, and blood complications like sulfhemoglobin, and methemoglobin. The oral exposure to anisidine hydrochloride resulted in cancer of the urinary bladder in male and female rats.
https://www.longdom.org/open-access/physicochemical-and-spectroscopic-characterization-of-biofield-energytreated-panisidine-paco-1000102.pdf

제조 방법

p-Anisidine is an important intermediate for synthesis of dye, medicine and perfume. Traditional preparation of p-Anisidine uses iron powder or sodium sulfide as reductant, which produces a large amount of waste and results in serious environment pollution problem. Liquid phase catalytic hydrogenation is not only an environmentally benign technique but also of high yield.
Synthesis of p-Anisidine by Hydrogenation with Raney-RuNiC as Catalyst

일반 설명

P-anisidine appears as brown crystals or dark brown solid. Characteristic amine odor. (NTP, 1992)

공기와 물의 반응

Insoluble in water.

반응 프로필

p-Anisidine may be sensitive to heat, light and moisture. Reacts with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents. Incompatible with alkaline materials. Incompatible with aldehydes, ketones and nitrates.

위험도

Strong irritant. Toxic when absorbed through the skin. Questionable carcinogen.

화재위험

p-Anisidine is flammable.

Safety Profile

Moderately toxic by several routes. A mild sensitizer. May cause a contact dermatitis. Mutation data reported. Questionable carcinogen. See also ANILINE. When heated to decomposition it emits toxic fumes of Nox

잠재적 노출

Anisidines are used in the manufacture of azo dyes; pharmaceuticals; textile-processing chemicals Incompatibilities: Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine,bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Attacks some coatings and some forms of plastic and rubber.

Carcinogenicity

Available data were inadequate to evaluate the carcinogenicity of p-anisidine.

운송 방법

UN2431 Anisidines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Purification Methods

Crystallise p-anisidine from H2O or aqueous EtOH. Dry it in a vacuum oven at 35o for 6hours and store it in a dry box. [More et al. J Am Chem Soc 108 2257 1986.] Purify it also by vacuum sublimation [Guarr et al. J Am Chem Soc 107 5104 1985]. [Beilstein 13 IV 1015.]

폐기물 처리

Dissolve in combustible solvent (alcohols, benzene, etc.) and spray solution into furnace equipped with afterburner and scrubber, or burn spill residue on sand and soda ash absorbent in a furnace.

P-아니시딘 준비 용품 및 원자재

원자재

4-나이트로아니솔 P-클로로니트로벤젠 황화나트륨 물 메틸알콜 수산화나트륨

준비 용품

2-Amino-6-methoxybenzothiazole cleaner LS beta-Methyl vinyl phosphate (MAP) Anisonitrile 1-(4-Methoxyphenyl)piperazine dihydrochloride 청색 054 기초염료 디스페르스 블루 79 인드메타신 부틸레이티드 하이드록시 아니솔 1-(4-Methoxyphenyl)piperazine 5-Methoxy-3-indazolecarboxylic acid Reactive Red Violet X-2R 3- 하이드 록시 -4- 메 톡시 -2- 나프탈닐리드 2-Hydroxy-N-(4-methoxyphenyl)-11H-benzo[a]carbazole-3-carboxamide 4-METHOXYBENZENEDIAZONIUM TETRAFLUOROBORATE 6-Methoxyquinaldine 4-메톡시페닐이소시아네이트 VARIAMINE BLUE B DIAZONIUM SALT Methacetin 4-메톡시-2-나이트로아닐린 4-chloro-1'-(4-methoxyphenyl)benzohydrazide 6-METHOXYBENZOTHIAZOLE-2-CARBOXYLIC ACID 2-(4-METHOXYPHENYL)HYDRAZINESULFONIC ACID SODIUM SALT MONOHYDRATE 4-METHOXYPHENYLTHIOUREA 4-Amino-2,5-dichlorophenol 6-히드록시퀴노린 6-Methoxyquinoline 6-METHOXY-4-METHYLQUINOLINE 5-Methoxyisatin 2-[[(4-메톡시페닐)메틸하이드라조노]메틸]-1,3,3-트라이메틸-3H-인돌륨 2-Cyano-6-methoxybenzothiazole 4-Aminopyrimidine 6-METHOXY-2-METHYLBENZOTHIAZOLE 2-CARBOMETHOXY-6-METHOXYBENZOTHIAZOLE 4-CHLORO-2-(4-METHOXY-PHENYLAMINO)-BENZOIC ACID Reactive Violet 8 4-[(4-methoxyphenyl)amino]benzenediazonium Pigment Red 190 5-METHOXYBENZIMIDAZOLE 황색 013 기초염료

P-아니시딘 공급 업체

글로벌( 539)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Firsky International Trade (Wuhan) Co., Ltd	+8615387054039	admin@firsky-cn.com	China	436	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +86-18949832763	info@tnjchem.com	China	2989	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58