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Papaverine hydrochloride

Papaverine hydrochloride 구조식 이미지
카스 번호:
61-25-6
상품명:
Papaverine hydrochloride
동의어(영문):
paph;dipav;lapav;vasal;dynovas;optenyl;pameion;pavabid;pavakey;pavased
CBNumber:
CB7689772
분자식:
C20H22ClNO4
포뮬러 무게:
375.85
MOL 파일:
61-25-6.mol

Papaverine hydrochloride 속성

녹는점
226°C (dec.)
저장 조건
Amber Vial, Refrigerator
용해도
H2O: 25 mg/mL
물리적 상태
powder
색상
white
수소이온지수(pH)
pH (20g/l, 25℃) : 3.0~4.0
수용성
freely soluble
감도
Light Sensitive
Merck
14,7019
BRN
3921435
안정성
Stable, but may be light sensitive.
CAS 데이터베이스
61-25-6(CAS DataBase Reference)
EPA
Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]- 6,7-dimethoxy-, hydrochloride(61-25-6)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,C,F
위험 카페고리 넘버 22-34-11
안전지침서 22-45-36/37/39-26-16
유엔번호(UN No.) UN 1544 6.1/PG 3
WGK 독일 1
RTECS 번호 NW8575000
F 고인화성물질 8
TSCA Yes
위험 등급 6.1
포장분류 III
HS 번호 29391900
유해 물질 데이터 61-25-6(Hazardous Substances Data)
독성 LD50 in mice, rats (mg/kg): 27.5, 20 i.v.; 150, 370 s.c. (Levis)
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P330 입을 씻어내시오.

Papaverine hydrochloride MSDS


Papaverine hydrochloride

Papaverine hydrochloride C화학적 특성, 용도, 생산

화학적 성질

PAPAVERINE HYDROCHLORIDE is Crystalline Solid

용도

Smooth muscle relaxant found in opium. Vasodilator (cerebral)

용도

Vasodilator;Phosphodiesterase inhibitor

용도

Anti-spasmodic, The treatment of erectile dysfunction

상표명

Pavabid (Hoechst Marion Roussel).

일반 설명

White powder. pH (0.05 molar solution) 3.9. pH (2% aqueous solution) 3.3.

일반 설명

Papaverine hydrochloride,6,7-dimethoxy-1-veratrylisoquinoline hydrochloride,was isolated by Merck in 1848 from opium,in which it occurs to the extent of about 1%. Althoughits natural origin is closely related to morphine, the pharmacologicalactions of papaverine hydrochloride areunlike those of morphine. Its main effect is as a spasmolyticon smooth muscle, acting as a direct, nonspecificrelaxant on vascular, cardiac, and other smooth muscle.Because of its broad antispasmodic action on ACh muscarinicreceptors, it is often called a nonspecific antagonist.Papaverine hydrochloride has been used in the treatmentof peripheral vascular disorders, but its use is limitedby lack of potency.
Papaverine hydrochloride interferes with the mechanismof muscle contraction by inhibiting the cyclic nucleotidephosphodiesterases in smooth muscle cells responsible forconverting cAMP and cyclic guanosine monophosphate(cGMP) to 5' -AMP and 5' -GMP, respectively. The increasedlevels of cAMP and cGMP are associated with muscle relaxation through their phosphorylation of myosinlight-chain kinase.

공기와 물의 반응

Water soluble.

반응 프로필

Papaverine hydrochloride is sensitive to light. .

건강위험

SYMPTOMS: Symptoms of exposure to Papaverine hydrochloride may include sleepiness, slowed respiration and slowed heart beat.

화재위험

Flash point data for Papaverine hydrochloride are not available, but Papaverine hydrochloride is probably combustible.

Safety Profile

Poison by ingestion, intraperitoneal, intraduodenal, intravenous, and subcutaneous routes. Human systemic effects: metabolic acidosis, pulse rate increase. An experimental teratogen. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also PAPAVERINE

효소 저해제

This opium metabolite (FWfree-base = 339.39 g/mol; CAS 61-25-6; triboluminescent solid; pKa = 8.07 at 25°C), also known as 1-[(3,4- dimethoxy-phenyl)methyl]-6,7-dimethoxyisoquinoline, is a a smooth muscle relaxant and cerebral vasodilator. It is most stable when stored as the hydrochloride or in aqueous solutions at pH 2.0-2.8. Target(s): acetylcholinesterase; Ca2+ current, voltage-dependent; 3’,5’-cyclicGMP phosphodiesterase, or cGMP phosphodiesterase (5,7,9, 12,24,26); 3’,5’-cyclic-nucleotide phosphodiesterase, or cAMP phosphodiesterase (4- 11,24-27); guanylate cyclase; HIV replication; HVJ (Sendai virus) replication; 15-hydroxyprostaglandin dehydrogenase; K+ current, Ca2+-activated oscillatory; K+ current, voltage-dependent transient outward; lactate dehydrogenase; malate dehydrogenase; monoamine oxidase; NADH dehydrogenase, or complex I; NAD(P)H dehydrogenase, or DT diaphorase; oxidative phosphorylation; purine transport; and rhodopsin kinase, weakly inhibited

Purification Methods

Recrystallise it from H2O. It sublimes at 140o/0.1mm. Its solubility in H2O is 5%. [Saunders & Srivastava J Pharm Pharmacol 3 78 1951, Biggs Trans Faraday Soc 50 800 1954.] The free base has m 148-150o, The picrate has m 186-189o(dec, 186-186.5o(dec) [Bobbitt J Org Chem 22 1729 1957]. [Beilstein 21 II 202, 21 III/IV 2788, 21/6 V 182.]

Papaverine hydrochloride 준비 용품 및 원자재

원자재

준비 용품


Papaverine hydrochloride 공급 업체

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Mainchem Co., Ltd.
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Chemwill Asia Co.,Ltd.
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QUALITY CONTROL CHEMICALS INC.
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J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
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Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40275 62
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 saleschina@alfa-asia.com China 30168 84
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44045 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18
0086-571-85864795 sales@capotchem.com China 18230 66
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1940 70
Chemsky(shanghai)International Co.,Ltd. 021-50135380
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