아미그달린
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아미그달린 속성
- 녹는점
- 223-226 °C
- 끓는 점
- 563.27°C (rough estimate)
- 알파
- -38.5 º (c=4, H2O)
- 밀도
- 1.4474 (rough estimate)
- 굴절률
- -40 ° (C=2, H2O)
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- H2O: 0.1 g/mL 뜨겁고 투명하거나 매우 희미하게 혼탁하며 무색입니다.
- 산도 계수 (pKa)
- 12.69±0.70(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- optical activity
- [α]20/D 39±2°, c = 2% in H2O
- 수용성
- 83g/L(25℃)
- Merck
- 14,597
- BRN
- 66856
- 안정성
- 흡습성
- InChIKey
- XUCIJNAGGSZNQT-SWRVSKMJSA-N
- LogP
- -2.237 (est)
- CAS 데이터베이스
- 29883-15-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 22 | ||
안전지침서 | 26-36/37/39-45-24/25 | ||
유엔번호(UN No.) | 2811 | ||
WGK 독일 | 3 | ||
RTECS 번호 | OO8450000 | ||
F 고인화성물질 | 10-21 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 29389090 | ||
유해 물질 데이터 | 29883-15-6(Hazardous Substances Data) | ||
독성 | LD50 orl-rat: 522 mg/kg WJMDA2 134,97,81 | ||
기존화학 물질 | KE-17719 |
아미그달린 C화학적 특성, 용도, 생산
개요
Laetrile는 과일과 채소, 특히 살구 구덩이와 쓴 아몬드에서 자연적으로 발견되는 화합물 아밀돌린의 정제 된 형태입니다. Amygdalin은 1830 년에 처음으로 분리되었고 러시아에서 항암제로 일찍 사용되었습니다. laetrile는 암의 통증을 완화시킵니다. 한 가지 이론은 암 세포가 다량의 효소 베타 - 글루코시다 아제를 포함한다는 것입니다. 이 효소는 편도체를 분해하여 암 세포를 죽이는 독성 화학 물질 인 시안화를 방출합니다.용도
1. 은 호흡기, 기침 및 천식을 억제 할 수 있습니다.2. 분말은 항 염증 및 진통 효과를 나타냅니다.
3. 은 항 종양 효과를 나타냅니다.
4. 혈당, 저지방 혈증을 낮출 수 있습니다.
개요
Amygdalin is a cyanogenic glycoside that has been found in seeds from plants of the Rosaceae family and has diverse biological activities. It induces cell cycle arrest at the G0/G1 phase, decreases cyclin A and Cdk2 levels, and inhibits cell growth in UMUC-3, RT112, and TCCSUP bladder cancer cells when used at concentrations ranging from 1.25 to 10 mg/ml. Amygdalin (3 mg/kg) reduces the number of primary microtubules and microvessels in aortic rings isolated from rats with diabetes induced by streptozotocin . In vivo, amygdalin reduces triglyceride, total cholesterol, and LDL levels and aortic sinus plaque area in an LDLR-/- mouse model of atherosclerosis. It also reduces production of TNF-α, IL-1β, and IL-6, as well as neutrophil and macrophage infiltration, in bronchoalveolar lavage fluid (BALF) in a mouse model of LPS-induced acute lung injury.화학적 성질
WHITE FINE CRYSTALLINE POWDER용도
Amygdalin, a cyanide containing glycoside, may be used as a substrate to identify, differentiate and characterize enzymes such as maltase(s), emulsin(s) and β-glucosidase(s).정의
ChEBI: An amygdalin in which the stereocentre on the cyanohydrin function has R-configuration.World Health Organization (WHO)
Laetrile, which consists mainly of amydgalin, a glycoside extracted from the kernels of apricots, peaches and other fruits, has been available for over 30 years in preparations purporting to be beneficial in the treatment of cancer. Although there is no evidence that these are efficacious, preparations continued to be widely used and, until the late 1970s, they were considered to be harmless. However, oral dosage forms, which may be broken down in the gut to hydrogen cyanide, have subsequently been shown to be potentially lethal. This has resulted in restrictive regulatory measures in several countries.일반 설명
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KGSafety Profile
Human poison by ingestion(infant data). Poison experimentally by ingestion. Anexperimental teratogen. Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.Purification Methods
D-Amygdalin recrystallises from water as the trihydrate, or from EtOH. It is present in bitter almonds. [Smith Chem Ber 64 1115 1931, Beilstein 17/8 V 188.]아미그달린 준비 용품 및 원자재
원자재
준비 용품
아미그달린 공급 업체
글로벌( 505)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Changsha Staherb Natural Ingredients Co., Ltd. | +86-0731-84213302 +86-18374838656 |
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Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
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Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 |
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Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
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Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 |
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HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615383190639 |
admin@86-ss.com | China | 1000 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9355 | 55 |
Rixing Chemical CO.,LTD | +86-13237129059 -13237129059 |
sales@rixingchemi.com | CHINA | 229 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |