5-(N,N-헥사메틸렌)-아밀로라이드
|
|
5-(N,N-헥사메틸렌)-아밀로라이드 속성
- 녹는점
- 224-225 °C
- 밀도
- 1.63±0.1 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMF: 3mg/mL; DMSO: 10mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL
- 물리적 상태
- 결정성 고체
- 산도 계수 (pKa)
- 8.81±0.46(Predicted)
- 색상
- Light yellow to yellow
안전
- 위험 및 안전 성명
위험품 표기 | T | ||
---|---|---|---|
위험 카페고리 넘버 | 23/24/25 | ||
안전지침서 | 22-36/37/39-45 | ||
유엔번호(UN No.) | 2811 | ||
WGK 독일 | 3 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III |
5-(N,N-헥사메틸렌)-아밀로라이드 C화학적 특성, 용도, 생산
개요
5-(N,N-hexamethylene)-Amiloride (HMA) is a derivative of amiloride with diverse biological activities. It is an allosteric antagonist of adenosine A2A receptors (Ki = 3.3 μM). HMA inhibits the cation-selective ion channel formed by the HIV-1 viral protein Vpu when used at a concentration of 50 μM, as well as budding of virus-like particles in HeLa cells expressing the HIV-1 proteins Gag and Vpu when used at a concentration of 10 μM. It also blocks the cation-selective ion channels formed by the hepatitis C virus (HCV) protein p7. HMA (40 μM) induces necrosis in and reduces the viability of MCF-7, MDA-MB-231, T47D, SK-BR-3, Met-1, and NDL breast cancer cells but not cardiomyocytes or uterine, pulmonary, and renal epithelial cells. HMA protects against post-ischemic contractile dysfunction and reduces coronary effluent creatine phosphokinase activity in a model of ischemia-reperfusion injury using isolated rat right ventricular free walls.정의
ChEBI: A member of the class of pyrazines that is amiloride in which the two amino hydrogens at position N-5 are replaced by a hexamethylene moiety, resulting in the formation of an azepane ring.Biochem/physiol Actions
Inhibitor of Na+/H+ antiport.5-(N,N-헥사메틸렌)-아밀로라이드 준비 용품 및 원자재
원자재
준비 용품
5-(N,N-헥사메틸렌)-아밀로라이드 공급 업체
글로벌( 50)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18629 | 58 |
Shenzhen Excellent Biotech Co., Ltd. | 13480692018 |
ramyan@ex-biotech.com | CHINA | 954 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 |
sales@tnjchem.com | China | 34571 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 24099 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33350 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 |
cooperation@kean-chem.com | China | 40068 | 58 |
HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 |
info@yuhaochemical.com | China | 2029 | 58 |
5-(N,N-헥사메틸렌)-아밀로라이드 관련 검색:
히드로염화 아밀로리드
Labetalol
Torasemide
5-(N,N-HEXAMETHYLENE)-AMILORIDE
AMILORIDE
Amiloride hydrochloride dihydrate
MIA
BENZAMIL HYDROCHLORIDE
PHENAMIL METHANESULFONATE
EIPA
PHENAMIL
3' 4'-DICHLOROBENZAMIL
AMILORIDE MONOHYDROCHLORIDE DIHYDRATE
5-(N-Ethyl-N-isopropyl)amiloridehydrochloride
3',4'-DICHLOROBENZAMIL HYDROCHLORIDE