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ChemicalBook >> CAS DataBase List >> CO-1686

CO-1686

CO-1686 price.
  • $9 - $3510
  • Product name: CO-1686
  • CAS: 1374640-70-6
  • MF: C27H28F3N7O3
  • MW: 555.55
  • EINECS:-0
  • MDL Number:MFCD26793864
  • Synonyms:CO-1686;AVL-301;CNX-419;CO-1686 (AVL-301);CO-1686/CO1686;N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide;Clovis CO-1686;CO-1686(free base)
Price49 Properties Safety Information Description
49 prices
Selected condition：
Brand
  • A1 Biochem Labs
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • TRC
Package
  • 20mg
  • 500mg
  • 1000mg
  • 10mM(in1mLDMSO)
  • 100.00mg
  • 250.00mg
  • 1.00g
  • 10mM*1mLinDMSO
  • 10mM(in 1mL DMSO)
  • 1mg
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 5G
  • ManufacturerA1 Biochem Labs
  • Product numberA1-04311
  • Product descriptionRociletinib
  • Packaging1g
  • Price$700
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA0039ID
  • Product descriptionN-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%
  • Packaging1mg
  • Price$9
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0039ID
  • Product descriptionN-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%
  • Packaging5mg
  • Price$12
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0039ID
  • Product descriptionN-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%
  • Packaging10mg
  • Price$14
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0039ID
  • Product descriptionN-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%
  • Packaging50mg
  • Price$36
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0039ID
  • Product descriptionN-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%
  • Packaging100mg
  • Price$47
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0039ID
  • Product descriptionN-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%
  • Packaging250mg
  • Price$76
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10304
  • Product descriptionCO-1686 98%
  • Packaging100MG
  • Price$50
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10304
  • Product descriptionCO-1686 98%
  • Packaging1G
  • Price$200
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10304
  • Product descriptionCO-1686 98%
  • Packaging5G
  • Price$650
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number2334AH
  • Product descriptionCO-1686
  • Packaging10mg
  • Price$151
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN5708
  • Product descriptionCO-1686
  • Packaging10mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2334AH
  • Product descriptionCO-1686
  • Packaging100mg
  • Price$320
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3320
  • Product descriptionCO-1686 (AVL-301)
  • Packaging100mg
  • Price$303
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3320
  • Product descriptionCO-1686 (AVL-301)
  • Packaging50mg
  • Price$182
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3320
  • Product descriptionCO-1686(AVL-301)
  • Packaging10mM(in 1mL DMSO)
  • Price$60
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
A1 Biochem Labs A1-04311 Rociletinib 1g $700 2021-12-16 Buy
aablocks AA0039ID N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98% 1mg $9 2026-05-28 Buy
aablocks AA0039ID N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98% 5mg $12 2026-05-28 Buy
aablocks AA0039ID N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98% 10mg $14 2026-05-28 Buy
aablocks AA0039ID N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98% 50mg $36 2026-05-28 Buy
aablocks AA0039ID N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98% 100mg $47 2026-05-28 Buy
aablocks AA0039ID N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide 98% 250mg $76 2026-05-28 Buy
ACHEMBLOCK 10304 CO-1686 98% 100MG $50 2026-05-27 Buy
ACHEMBLOCK 10304 CO-1686 98% 1G $200 2026-05-27 Buy
ACHEMBLOCK 10304 CO-1686 98% 5G $650 2026-05-27 Buy
AK Scientific 2334AH CO-1686 10mg $151 2021-12-16 Buy
AK Scientific SYN5708 CO-1686 10mg $160 2021-12-16 Buy
AK Scientific 2334AH CO-1686 100mg $320 2021-12-16 Buy
ApexBio Technology A3320 CO-1686 (AVL-301) 100mg $303 2026-05-06 Buy
ApexBio Technology A3320 CO-1686 (AVL-301) 50mg $182 2026-05-06 Buy
ApexBio Technology A3320 CO-1686(AVL-301) 10mM(in 1mL DMSO) $60 2021-12-16 Buy
Next Last

Properties

Melting point :202 - 205°C (dec.)
Density :1.372±0.06 g/cm3(Predicted)
storage temp. :Amber Vial, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :13.23±0.70(Predicted)
color :Off-White
CAS DataBase Reference :1374640-70-6

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

CO-1686 is an irreversible kinase inhibitor that specifically targets mutant forms of the epidermal growth factor receptor (EGFR) including T790M (Ki = 21.5 nM) with significantly reduced activity at the wild-type form of the receptor (Ki = 303.3 nM). CO-1686 has been shown to inhibit the proliferation of non-small cell lung cancer (NSCLC) cells expressing mutant EGFR with GI50 values ranging from 7-32 nM in vitro, inducing apoptosis. It also demonstrates anti-tumor activity in NSCLC EGFR mutant xenograft and transgenic models dosed orally at 100 mg/kg/day.

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Suppliers and manufacturers

Shanghai Boyle Chemical Co., Ltd. J & K SCIENTIFIC LTD. Chembest Research Laboratories Limited WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. Nanjing Chemlin Chemical Co., Ltd Shanghai Hanhong Scientific Co.,Ltd. Jinan Trio PharmaTech Co., Ltd. Dalian Meilun Biotech Co., Ltd. Shanghai Xiannuo Biotechnology Co., Ltd. Shanghai SynFarm Pharmaceutical Technology Co., Ltd.