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ChemicalBook >> CAS DataBase List >> Empagliflozin

Empagliflozin

Empagliflozin price.
  • $5 - $1950
  • Product name: Empagliflozin
  • CAS: 864070-44-0
  • MF: C23H27ClO7
  • MW: 450.91
  • EINECS:620-176-8
  • MDL Number:MFCD22566222
  • Synonyms:EMPAGLIFLBZIN;EMpagliflozin;BI-10773;EMpagliflozin/ BI-10773;D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]M ethyl]phenyl]-, (1S)-;(1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucitol Empagliflozin BI 10773;Empagliflozin Impurity A;(1S)-1,5-Anhydro-1-C-{4-chloro-3-[(4-{[(3S)-oxolan-3-yl]oxy}phenyl)methyl]phenyl}-D-glucitol
42 prices
Selected condition:
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • TRC
Package
  • 10mg
  • 10mM(in 1mL DMSO)
  • 5MG
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 500mg
  • 1g
  • 5g
  • 10g
  • 25g
  • 100g
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3619-M010
  • Product descriptionEmpagliflozin ≥98%(HPLC)
  • Packaging10mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3619-M050
  • Product descriptionEmpagliflozin ≥98%(HPLC)
  • Packaging50mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX5927
  • Product descriptionEmpagliflozin
  • Packaging10g
  • Price$187
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA112500
  • Product description(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 98+%
  • Packaging10mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA112500
  • Product description(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 98+%
  • Packaging50mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA112500
  • Product description(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 98+%
  • Packaging100mg
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA112500
  • Product description(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 98+%
  • Packaging250mg
  • Price$14
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA112500
  • Product description(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 98+%
  • Packaging1g
  • Price$34
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA112500
  • Product description(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 98+%
  • Packaging5g
  • Price$89
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA112500
  • Product description(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 98+%
  • Packaging10g
  • Price$139
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA112500
  • Product description(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 98+%
  • Packaging25g
  • Price$277
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA112500
  • Product description(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 98+%
  • Packaging100g
  • Price$748
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0046689
  • Product descriptionEMPAGLIFLOZIN 95.00%
  • Packaging5MG
  • Price$459.45
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4601
  • Product descriptionEmpagliflozin(BI10773)
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberSY046855
  • Product description(2S,3R,4R,5S,6R)-2-[4-Chloro-3-[4-[[(S)-3-tetrahydrofuranyl]oxy]benzyl]phenyl]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
  • Packaging10g
  • Price$165
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3361
  • Product descriptionEmpagliflozin
  • Packaging10mg
  • Price$29
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3619-M010 Empagliflozin ≥98%(HPLC) 10mg $70 2021-12-16 Buy
Adipogen Life Sciences AG-CR1-3619-M050 Empagliflozin ≥98%(HPLC) 50mg $180 2021-12-16 Buy
AK Scientific X5927 Empagliflozin 10g $187 2021-12-16 Buy
Ambeed A112500 (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 98+% 10mg $5 2021-12-16 Buy
Ambeed A112500 (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 98+% 50mg $6 2021-12-16 Buy
Ambeed A112500 (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 98+% 100mg $9 2021-12-16 Buy
Ambeed A112500 (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 98+% 250mg $14 2021-12-16 Buy
Ambeed A112500 (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 98+% 1g $34 2021-12-16 Buy
Ambeed A112500 (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 98+% 5g $89 2021-12-16 Buy
Ambeed A112500 (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 98+% 10g $139 2021-12-16 Buy
Ambeed A112500 (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 98+% 25g $277 2021-12-16 Buy
Ambeed A112500 (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 98+% 100g $748 2021-12-16 Buy
American Custom Chemicals Corporation API0046689 EMPAGLIFLOZIN 95.00% 5MG $459.45 2021-12-16 Buy
ApexBio Technology A4601 Empagliflozin(BI10773) 10mM(in 1mL DMSO) $55 2021-12-16 Buy
Arctom SY046855 (2S,3R,4R,5S,6R)-2-[4-Chloro-3-[4-[[(S)-3-tetrahydrofuranyl]oxy]benzyl]phenyl]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol 10g $165 2021-12-16 Buy
AvaChem 3361 Empagliflozin 10mg $29 2021-12-16 Buy

Properties

Boiling point :665℃
Density :1.398
Flash point :356℃
storage temp. :2-8°C
solubility :insoluble in H2O; ≥20.75 mg/mL in DMSO; ≥7.06 mg/mL in EtOH with ultrasonic
form :solid
pka :13.23±0.70(Predicted)
color :White
Stability :Hygroscopic
InChIKey :OBWASQILIWPZMG-QZMOQZSNSA-N
SMILES :C1=C(CC2=CC([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)=CC=C2Cl)C=CC(O[C@H]2CCOC2)=C1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H362 May cause harm to breast-fed children Reproductive toxicity, effects on or via lactation Additional category P201, P260, P263, P264, P270,P308+P313
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P263 Avoid contact during pregnancy/while nursing.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Empagliflozin(trade name Jardiance) is an inhibitor of the sodium glucose co-transporter-2 (SGLT-2), and causes sugar in the blood to be excreted by the kidneys and eliminated in urine. On August 1, 2014, the Food and Drug Administration (FDA) officially approved the drug for the treatment of type 2 diabetes, to improve and control blood glucose of adults. Empagliflozin is the third SGLT-2 inhibiting drugs approved by FDA. Another two SGLT-2 inhibitor drugs, canagliflozin and dapagliflozin, belonging to Johnson Pharmaceuticals, AstraZeneca and Bristol-Myers Squibb respectively, are approved by FDA in November 2013 and January 2014 respectively. The new drug Empagliflozin’s application to FDA can be described as twists and turns. In March 2014, due to a large particle contamination incident at the empagliflozin production plant in Boehringer, the application of new drug submitted by the Boehringer-Eli Lilly Alliance was rejected by FDA. In June 2014, after reviewing the summary and material submitted by Boehring in March, confirming that the quality management and compliance system of the Boehring drug production facility was acceptable, FDA withdrew the previously issued warning letter. The Boehringer-Eli Lilly Alliance also filed an application with the FDA on June 17th.

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