| Company Name: |
Abmart Inc
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| Tel: |
4006-123-828 13162017139 |
| Email: |
abmartname@qq.com |
| Products Intro: |
Cas:
ProductName:Progestin Receptor Beta Antibody
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| Company Name: |
GeneTex, Inc.
|
| Tel: |
0755-26755892 1-949-553-1900 |
| Email: |
GeneTexname@qq.com |
| Products Intro: |
Cas:
ProductName:Progestin Receptor beta antibody
|
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| | Progestin Chemical Properties |
| Melting point | 128-132 °C (lit.) | | Boiling point | 394.13°C (rough estimate) | | alpha | 186 º (c=1, ethanol) | | density | d23 1.166; d20 1.171 | | refractive index | 182 ° (C=2, Dioxane) | | Fp | 2℃ | | storage temp. | room temp | | solubility | H2O: 25 mg/mL, may be clear to slightly hazy | | form | powder | | color | Yellow to yellow-brown | | biological source | synthetic (organic) | | Water Solubility | <0.1 g/100 mL at 19 ºC | | Merck | 7773 | | BRN | 1915950 | | Henry's Law Constant | 1.5×102 mol/(m3Pa) at 25℃, HSDB (2015) | | BCS Class | 4 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | Major Application | pharmaceutical (small molecule) | | Cosmetics Ingredients Functions | SKIN CONDITIONING | | InChI | 1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 | | InChIKey | RJKFOVLPORLFTN-LEKSSAKUSA-N | | SMILES | CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C | | LogP | 3.870 | | CAS DataBase Reference | 57-83-0(CAS DataBase Reference) | | NIST Chemistry Reference | Progesterone(57-83-0) | | EPA Substance Registry System | Progesterone (57-83-0) |
| Hazard Codes | Xn,T,F | | Risk Statements | 40-45-62-36-20/21/22-11 | | Safety Statements | 36/37-45-53-16 | | RIDADR | UN 1648 3 / PGII | | WGK Germany | 3 | | RTECS | TW0175000 | | TSCA | TSCA listed | | HS Code | 29372390 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Carc. 2
Lact.
Repr. 1A | | Hazardous Substances Data | 57-83-0(Hazardous Substances Data) | | Toxicity | LD50 intraperitoneal in rat: 327mg/kg |
| | Progestin Usage And Synthesis |
| Description | Progestin is the synthetic (human-made) form of progesterone. Progesterone is a hormone that occurs naturally in your body. Some people need treatment with progestin to treat symptoms or conditions.
| | Physical properties | Progestin is a white powder, melting point 121°C. Stable in air. Insoluble in water. | | Uses |
Progestin is a synthetic (human-made) form of progesterone that helps treat certain conditions. It is can used to treatment for issues with menstruation, symptoms of menopause, and many others.
| | Health Hazard | Acute/chronic hazards: Progesterone may be absorbed through the skin. | | Side effects |
Common side effects of oral Progesterone include: chest pain, chills, cold or flu-like symptoms; cough or hoarseness; fever, and problems with urination. Rare side effects include: clear or bloody discharge; dimpling of the breast skin, lumps in the breast or armpit; persistent crusting or flaking; redness or swelling of the breast; and sores on the breast skin that do not heal. Other side effects that may occur are: abdominal or stomach pain; constipation, difficulty breathing, dizziness, fast, strong, or irregular heartbeat or pulse; headache, measles, indigestion, itching, joint pain, stiffness, or swelling; rash.
| | Synthesis |
Progestin, pregn-4-en-3,20-dione (28.3.1), is made by oxidizing pregnenolon with aluminum isopropylate in the presence of cyclohexanone as a proton acceptor (Oppenauer oxidation). Progestin itself is made by subsequent oxidation and further cleavage of the side chain of stigmasterin, a sterin of plant origin that is isolated from soybeans.
| | Physiological effects |
Progestin is believed to act by inducing decidualization and atrophy of the endometrial tissue within endometriotic implants. Progestin also interfere with follicular growth probably via a central mechanism on the pituitary–hypothalamic unit, but a local ovarian effect is also possible. This will result in decreased estrogen levels.
| | Toxicity |
Low toxicity
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| | Progestin Preparation Products And Raw materials |
| Raw materials | Cyclohexanone-->16-Dehydropregnenolone acetate-->Aluminium isopropoxide-->Pregnenolone | | Preparation Products | Deoxycorticosterone acetate-->Dexamethasone-17-acetate-->17,21-dihydroxy-16beta-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate-->9-Bromo-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione-21-acetate-->9,11β-Epoxy-17-hydroxy-16β-methyl-3,20-dioxo-9β-pregna-1,4-diene-21-yl Acetate-->16,17-Epoxypregna-5,9(11)-diene-3,20-dione cyclic bis(1,2-ethanediyl acetal)-->11alpha-Hydroxyprogesterone-->17-Hydroxy-16-methylpregna-5,9(11)-diene-3,20-dione 3,20-diethyleneketal-->Pregnanedione-->16-Dehydroprogesterone-->Methyl 4-aza-5alpha-androsta-3-one-17beta-carboxylate-->Pregna-4,14-diene-3,20-dione-->5α-Pregnane-3,20-dione-->4-Aza-5a-androstan-1-ene-3-one-17b-carboxylic acid |
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