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Dimethyl chlorothiophosphate

Dimethyl chlorothiophosphate Basic information
Product Name:Dimethyl chlorothiophosphate
Synonyms:O,O’-Dimethylphosphonochloridothioate;o,o-Dimethyl chloridothiophosphate;O,O-Dimethyl chlorophosphorothioate;O,O-Dimethyl chlorothionophosphate;O,O-Dimethyl chlorothiophosphate;O,O-Dimethyl phosphorothionochloridate;O,O-Dimethyl thionophosphorochloridate;O,O-Dimethyl thionophosphoryl chloride
Product Categories:Biochemistry;Nucleosides, Nucleotides & Related Reagents;Phosphorylating and Phosphorothioating Agents;Protecting Agents, Phosphorylating Agents & Condensing Agents;Pharmaceutical Intermediates
Mol File:2524-03-0.mol
Dimethyl chlorothiophosphate Structure
Dimethyl chlorothiophosphate Chemical Properties
Boiling point 66-67 °C16 mm Hg(lit.)
density 1.322 g/mL at 25 °C(lit.)
vapor pressure 0.67 psi ( 20 °C)
refractive index n20/D 1.482(lit.)
Fp 221 °F
solubility Chloroform (Sparingly), Methanol (Slightly)
form Oil
color Colourless
Water Solubility slowly hydrolyzes
Stability:Moisture Sensitive
CAS DataBase Reference2524-03-0(CAS DataBase Reference)
NIST Chemistry ReferencePhosphorochloridothioic acid, o,o-dimethyl ester(2524-03-0)
EPA Substance Registry SystemDimethyl chlorothiophosphate (2524-03-0)
Safety Information
Hazard Codes T
Risk Statements 23/24/25-34-23-21/22
Safety Statements 23-26-36/37/39-45-24/25
RIDADR UN 2267 6.1/PG 2
WGK Germany 3
RTECS TD1830000
HazardClass 6.1(a)
PackingGroup II
HS Code 29309099
Hazardous Substances Data2524-03-0(Hazardous Substances Data)
Toxicitymouse,LC50,inhalation,320mg/m3/2H (320mg/m3),"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 56, 1982.
MSDS Information
O,O-Dimethyl phosphorochloridothioate English
SigmaAldrich English
Dimethyl chlorothiophosphate Usage And Synthesis
Chemical Propertiesclear colorless to light yellow liquid
UsesDimethyl chlorothiophosphate is used as an intermediate in the manufacture of insecticides, pesticides, fungicides, oil and gasoline additives, plasticizers, corrosion inhibitors, flame-retardants, and flotation agents.
PreparationDimethyl chlorothiophosphate is prepared by reaction of phosphorus pentasulfide & methyl alcohol followed by reaction of the resulting dimethyl phosphorodithioate with chlorine.
General DescriptionDimethyl chlorothiophosphate is a colorless to light amber liquid. Used as a chemical intermediate for insecticides, pesticides, and fungicides; oil and gasoline additives; plasticizers; corrosion inhibitors; flame retardants; and flotation agents. Not registered as a pesticide in the U.S. (EPA, 1998)
Reactivity ProfileOrganothiophosphates, such as Dimethyl chlorothiophosphate, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Health HazardDimethyl chlorothiophosphate is a strong irritant to the eyes, skin, and mucous membranes.
Fire HazardDimethyl chlorothiophosphate may burn but does not ignite readily. Dimethyl chlorothiophosphate may ignite combustibles (wood, paper, oil, etc.). When heated Dimethyl chlorothiophosphate emits very toxic fumes of chlorine containing compounds, phosphorus oxides, and sulfur oxides.
Flammability and ExplosibilityNon flammable
Safety ProfilePoison by inhalation. Moderately toxic by ingestion and skin contact. Corrosive. When heated to decomposition it emits very toxic fumes of Cl-, POx, and SOx
Tag:Dimethyl chlorothiophosphate(2524-03-0) Related Product Information
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