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Propanolol

Propanolol Suppliers list
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-188-71490254
Email: peter@hubeijusheng.com
Products Intro: Product Name:Propranolol
CAS:525-66-6
Purity:99% Package:5KG;1KG Remarks:C16H21NO2
Company Name: QUALITY CONTROL CHEMICALS INC.
Tel: (323) 306-3136
Email: orders@qcchemical.com
Products Intro: Product Name:Propranolol
CAS:525-66-6
Purity:95% Package:10mg;25mg;50mg;100mg;250mg Remarks:Brand: QCC CAT#QP181500
Company Name: Chengdu Saint - Kay Biotechnology Co., Ltd.  Gold
Tel: 15882256948
Email: 676046971@qq.com
Products Intro: CAS:525-66-6
Purity:0.98 Package:MG G
Company Name: LGM Pharma  
Tel: 1-(800)-881-8210
Email: inquiries@lgmpharma.com
Products Intro: Product Name:Propranolol
CAS:525-66-6
Purity:Typically NLT 98%
Company Name: Beijing HuaMeiHuLiBiological Chemical   
Tel: 010-56205725;010-86181995
Email: waley188@sohu.com
Products Intro: Product Name:Propranolol
CAS:525-66-6
Purity:99% Package:25kg
Propanolol Basic information
Product Name:Propanolol
Synonyms:Propranolol Base;1-[Isopropylamino]-3-[1-naphthyloxy]-2-propanol;2-Propanol, 1-(1-methylethyl)amino-3-(1-naphthalenyloxy)-;1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol;1-(1-Naphthyloxy)-3-(isopropylamino)-2-propanol;2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)- (7CI, 8CI);2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)- (9CI);Betalong
CAS:525-66-6
MF:C16H21NO2
MW:259.34344
EINECS:208-378-0
Product Categories:
Mol File:525-66-6.mol
Propanolol Structure
Propanolol Chemical Properties
Melting point 163-164 °C
Boiling point 402.6°C (rough estimate)
density 1.0280 (rough estimate)
refractive index 1.5500 (estimate)
CAS DataBase Reference525-66-6
NIST Chemistry ReferencePropranolol(525-66-6)
Safety Information
MSDS Information
Propanolol Usage And Synthesis
Chemical PropertiesColorless crystals.Soluble in water and alcohol; insoluble in benzene and ether.
UsesCardiac depressant (anti-arrhythmic); anti-adrenergic (β-receptor).
DefinitionChEBI: A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Brand nameInderal (Wyeth); Innopran (Reliant).
HazardHighly toxic.
Contact allergensPropranolol is a beta-blocking agent that was responsible for the sensitization of workers in drug synthesis. In one case, epichlorhydrin was used for the production of drugs propranolol and oxprenolol. Crossreactivity is expected between beta-blockers.
Enzyme inhibitorThis b-blocking antihypertensive (FWfree-base = 259.35 g/mol; CAS 525-66- 6; stable at acidic/neutral pH, but not at alkaline pH), widely known as Inderal? and systematically named as 1-[(1-methylethyl)amino]-3-(1- naphthalenyloxy)-2-propanol, is widely used to treat hypertension, cardiac arrhythmia, and migraines. Propranolol is both a b-adrenergic receptor antagonist and a 5-HT1/5-HT2 serotonin receptor antagonist. While the (S)- enantiomer is the active b-antagonist, racemic propranolol is most often dispensed. Propranolol is also effective for controlling intentional tremor, but with a requirement for escalating drug levels, when used chronically. For his germinal work on b-antagonists, including propranolol, the Scottish pharmacologist James Whyte Black was awarded the Nobel Prize in Physiology or Medicine in 1988. Key Pharmacokinetic Parameters: See Appendix II in Goodman & Gilman’s THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, 12th Edition (Brunton, Chabner & Knollmann, eds.) McGraw-Hill Medical, New York. Target(s): acetylcholine esterase; b-adrenergic receptor; [b-adrenergic-receptor] kinase; alcohol dehydrogenase; aldehyde dehydrogenase; 1- alkylglycerophosphocholine O-acetyltransferase; 5-aminolevulinate synthase; Ca2+-dependent ATPase; cellobiohydrolase; choline-phosphate cytidylyltransferase; cholinesterase; CYP2D and a few other cytochrome P450, or CYP, family members; glycosylphosphatidylinositol diacylglycerol-lyase; hexokinase; K+ channels, ATP-sensitive; lecithin:cholesterol acyltransferase, or LCAT; lipoprotein lipase; Mg2+-dependent ATPase; Na+/K+- exchanging ATPase; phosphatidate phosphatase; phospholipase A; prolyl hydroxylase, or procollagen-proline monooxygenase; prostaglandin-endoperoxide synthase, or cyclooxygenase; protein kinase C; serotonin 5-HT1/5-HT2 receptor; thyroxine 5’-deiodinase; and xanthine oxidase.
Propanolol Preparation Products And Raw materials
Tag:Propanolol(525-66-6) Related Product Information
1-(2,6-Dimethylphenoxy)-2-propanamine DL-PROPRANOLOL-D7 (RING-D7) 5-Hydroxy Propranolol 7-Hydroxy Propranolol N-nitrosopropranolol AURORA KA-6823 S-PROPRANOLOL Propranolol hydrochloride Pranolium chloride (S)-(-)-PROPRANOLOL HYDROCHLORIDE PROPRANOLOL GLUCURONIDE SODIUM SALT DL-PROPRANOLOL-[4-3H] HYDROCHLORIDE (R)-(+)-PROPRANOLOL Propanolol MEN 935 RAC PROPANOLOL-D7 4'-methylthiopropranolol Adimolol