- Nifuratel
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- US $0.00-0.00 / KG
- 2020-05-04
- CAS:4936-47-4
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 600 Tons
- Nifuratel
-
- US $50.00 / g
- 2020-04-25
- CAS:4936-47-4
- Min. Order: 10g
- Purity: 99.8%
- Supply Ability: 10tons
- Nifuratel
-
- US $1.00 / Kg/Drum
- 2019-10-30
- CAS:4936-47-4
- Min. Order: 25Kg/Drum
- Purity: 99%
- Supply Ability: 1ton
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| Product Name: | Nifuratel | | Synonyms: | 5-[(Methylsulfanyl)Methyl]-4-[(E)-[(5-nitrofuran-2-yl)Methylidene]aMino]-1,3-oxazolidin-2-one;3-[(5-Nitro-2-furfurylidene)aMino]-5-[(Methylthio)Methyl]-2-oxazolidinone;5-(MethylMercaptoMethyl)-3-(5-nitro-2-furfurylidenaMino)-2-oxazolidinone;2-Oxazolidinone,5-[(Methylthio)Methyl]-3-[[(5-nitro-2-furanyl)Methylene]aMino]-;MACMIROR;5-[(METHYLTHIO)METHYL]-3-[[(5-NITRO-2-FURANYL)METHYLENE]AMINO-]-2-OXAZO-LIDINONE;5-methylthiomethyl-3-(5-nitrofurfurylideneamino)-2-oxazolidone;NIFURATEL | | CAS: | 4936-47-4 | | MF: | C10H11N3O5S | | MW: | 285.28 | | EINECS: | 225-576-2 | | Product Categories: | Pharmaceuticals;APIS;API;Intermediates & Fine Chemicals | | Mol File: | 4936-47-4.mol |  |
| | Nifuratel Chemical Properties |
| Melting point | 176-178°C | | Boiling point | 423.6±53.0 °C(Predicted) | | density | 1.57±0.1 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | pka | -2.49±0.40(Predicted) | | CAS DataBase Reference | 4936-47-4(CAS DataBase Reference) |
| Risk Statements | 68 | | Safety Statements | 36/37 | | HS Code | 29321900 | | Toxicity | LD50 oral in mouse: > 4500mg/kg |
| | Nifuratel Usage And Synthesis |
| The main effects | Nifuratel is a derivative of nitrofuran , it is a broad spectrum antibiotic with broad-spectrum antimicrobial effect, Nystatin is a polyene antifungal,it has strong effects on trichomoniasis, bacteria, Candida albicans , it plays a strong killing role especially in common pathogens for gynecological infections such as gram-positive and gram-negative bacteria, trichomoniasis, mold, chlamydia and mycoplasma . After oral administration, it is absorbed by gastrointestinal ,most of it is excreted through the kidneys, it has higher concentrations in blood, urine, genital tissues ,so it can have a strong antibacterial effect in the urinary system, and its metabolites still have antibacterial activity, and it is excreted through the urine . Oral nifuratel can be rapidly absorbed, after oral administration of 200mg, the peak plasma concentration is 9.48μg/L in two hours . The animals acute toxicity test proves that in toxicity of the product is mild.
Nifuratel indications include:
1, bacterial vaginosis, trichomonas vaginitis, vulvovaginal candidiasis, vaginal mixed infections.
2, urinary tract infections.
3, gastrointestinal amoebiasis and trichomoniasis Jia.
The above information is edited by the chemicalbook of Tian Ye. | | Chemical Properties | Yellow Solid | | Originator | Macmiror,Poli,Italy,1965 | | Uses | Nifuratel is a drug used as an antibacterial, antifungal, antiprotozoal (Trichomonas). Nifuratel appears to have a broad antibacterial spectrum of action and is effective against Chlamydia trachomatis
and Mycoplasma spp. as well as fungal infections from Candida spp. | | Manufacturing Process | In an initial step of reactions, methyl mercaptan is reacted with
epichlorohydrin to give 1chloro-3-methylthio-2-propanol. That is reacted with
hydrazine hydrate to give 3-methylmercapto-2-hydroxypropyl hydrazine.
11.8 grams of diethyl carbonate (0.1 mols) and a solution of sodium
methoxide prepared from 0.12 gram of sodium in 4 cc of anhydrous methanol,
were added to 13.2 grams of 3-methylmercapto-2-hydroxypropyl hydrazine.
After the reaction vessel had been fitted with a Liebig condenser, the reaction
mixture was heated by means of an oil bath which was gradually heated up to
110°C, to remove first methyl alcohol and then ethyl alcohol formed during
the reaction. After about two-thirds of the theoretical amount of ethyl alcohol
had been distilled off, the heating was discontinued and the reaction mixture
was diluted with 50 cc of ethyl alcohol and poured into a 5-nitro-2-
furfuraldehyde solution prepared by boiling for 30 minutes 0.1 mol of
nitrofurfuraldehyde diacetate in 100 ml of ethyl alcohol and 50 ml of 1:10
sulfuric acid.
A yellow crystalline precipitate was immediately formed, which, after
crystallization from acetic acid, melted at 182°C and consisted of N-(5-nitro-
2-furfurylidene)-3-amino-5-methyl-mercaptomethyl-2-oxazolidinone. | | Brand name | Macmiror (Polichimica Sap, Italy); Magmilor
(Polichimica Sap, Italy); Polmiror (Polichimica Sap,
Italy); Tydantil (Polichimica Sap, Italy). | | Therapeutic Function | Vaginal antiinfective | | Pharmaceutical Applications | A synthetic compound available as tablets and vaginal preparations.
It is poorly soluble in water, but readily soluble in
dimethylformamide.
The activity is similar to that of nitrofurantoin but it is
more active, especially against Gram-negative anaerobes.
It also has modest, but clinically useful, activity against
Candida albicans. Little is known about the pharmacokinetics.
It structurally resembles furazolidone, and may
undergo a similar degree of metabolism. It does not achieve
therapeutic concentrations in the bloodstream after oral
administration and it seems likely that the antibacterial
activity in urine is due to active metabolites. There is little
or no systemic absorption when vaginal suppositories are
used.
As with other members of the group, side effects are mostly
associated with the upper gastrointestinal tract. It is used to
treat urinary infections and vaginal candidiasis. |
| | Nifuratel Preparation Products And Raw materials |
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