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Hesperadin

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Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: 21-51619050
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Products Intro: CAS:422513-13-1
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G
Company Name: Biochempartner
Tel: 0086-13720134139
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Products Intro: Product Name:Hesperadin
CAS:422513-13-1
Purity:98% HPLC LCMS Package:10G;20G
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
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Products Intro: Product Name:Hesperadin
CAS:422513-13-1
Purity:0.99 Package:5KG;1KG
Company Name: career henan chemical co
Tel: +86-0371-86658258
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Products Intro: Product Name:Hesperadin
CAS:422513-13-1
Purity:99% Package:1g;1USD
Company Name: Dideu Industries Group Limited
Tel: 029-88380327 +8617691182729
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Products Intro: Product Name:Hesperadin
CAS:422513-13-1
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer

Hesperadin manufacturers

  • Hesperadin
  • $1.00 / 1g
  • 2020-01-13
  • CAS:422513-13-1
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 1ton
Hesperadin Basic information
Product Name:Hesperadin
Synonyms:(Z)-N-(2-oxo-3-(phenyl(4-(piperidin-1-ylmethyl)phenylamino)methylene)indolin-5-yl)ethanesulfonamide;Hesperadin Hesperadine;N-[2,3-Dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]ethanesulfonamide Hesperadin;Hesperadin, >=98%;Hesperadin;Hesperadin hydrochloride;N-[(3Z)-2-Oxo-3-[phenyl-[4-(piperidin-1-ylMethyl)anilino]Methylidene]-1H-indol-5-yl]ethanesulfonaMide;Hesperadine
CAS:422513-13-1
MF:C29H32N4O3S
MW:516.65
EINECS:200-258-5
Product Categories:Inhibitor;Inhibitors
Mol File:422513-13-1.mol
Hesperadin Structure
Hesperadin Chemical Properties
Melting point 228 °C
density 1.326
storage temp. Refrigerator
solubility DMSO, Methanol
form Solid
pka9.14±0.20(Predicted)
color Yellow
CAS DataBase Reference422513-13-1
Safety Information
MSDS Information
Hesperadin Usage And Synthesis
DescriptionHesperadin is a multi-kinase inhibitor. It inhibits human Aurora kinase B (IC50 = 250 nM) and its T. brucei homolog Aurora kinase-1 (IC50 = 40 nM) in in vitro kinase assays. Hesperadin (1 μM) inhibits AMPK, LCK, MKK1, MAPKAP-K1, CHK1, and PHK in a panel of 25 kinases. It also inhibits MEKK2 in ATPase and transphosphorylation assays with IC50s of 60 and 34 nM, respectively. Hesperadin (50-100 nM) induces polyploidy and defects in cytokinesis and spindle assembly as well as inhibits proliferation of HeLa cells and overrides mitotic arrest induced by paclitaxel or monastrol . Hesperadin also induces toxicity in HepG2 cells with a toxic concentration (TC50) value of less than 0.2 μM. It inhibits replication of clinical isolates of influenza A and B viruses with EC50s ranging from 0.22 to 2.21 μM in a plaque formation assay. Hesperadin inhibits the growth of T. brucei, L. major promastigotes and amastigotes, and P. falciparum with EC50 values ranging from 0.01 to 2.37 μM, but has less activity against T. cruzi (EC50 = 39 μM).
UsesHesperadin phosphorylates human mitotic protein complexes that control physiological changes within the cell to allow for proper and successful chromosome segregation. It also targets aurora kinases i n cancer treatment, affecting the chromosomes’regulation during mitosis.
UsesHesperadin phosphorylates human mitotic protein complexes that control physiological changes within the cell to allow for proper and successful chromosome segregation. It also targets aurora kinases in cancer treatment, affecting the chromosomes’ regulation during mitosis.
DefinitionChEBI: An oxindole that is indolin-2-one which is substituted at position 5 by an (ethylsulfonyl)nitrilo group and at position 2 by a methylidene group, which is itself substituted by a phenyl group and a [4-(piperidin-1-ylmethyl)phenyl]amino group. An Aurora B k nase inhibitor, it is used to inhibit chromosome alignment and segregation.
Hesperadin Preparation Products And Raw materials
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