Dexrazoxane

Dexrazoxane Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
Email: info@dakenchem.com
Products Intro: Product Name:Dexrazoxane
CAS:24584-09-6
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:24584-09-6
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Email: zheyansh@163.com
Products Intro: Product Name:Dexrazoxane
CAS:24584-09-6
Purity:98%,BR Package:1g
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Dexrazoxane
CAS:24584-09-6
Purity:98% Package:1KG;1USD
Company Name: Zhejiang ZETian Fine Chemicals Co. LTD
Tel:
Email: stella@zetchem.com
Products Intro: Product Name:Dexrazoxane
CAS:24584-09-6
Purity:0.99 Package:5KG;1KG Remarks:Have any requirements, pls contact sales@zetchem.com

Lastest Price from Dexrazoxane manufacturers

  • Dexrazoxane
  • US $1.00 / KG
  • 2021-10-18
  • CAS:24584-09-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 50
  • Dexrazoxane
  • US $0.00 / Kg/Bag
  • 2021-09-29
  • CAS:24584-09-6
  • Min. Order: 1g
  • Purity: 98%-102%
  • Supply Ability: 10KGS
  • Dexrazoxane
  • US $15.00-10.00 / KG
  • 2021-07-13
  • CAS:24584-09-6
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
Dexrazoxane Basic information
Product Name:Dexrazoxane
Synonyms:DEXRAZOXANE;(s)-4,4'-(1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione;4’-(1-methyl-1,2-ethanediyl)bis-6-piperazinedion(+)-4;4’-propylenedi-6-piperazinedion(+)-4;adr529;cardioxane;DEXTRAZOXANE;DEXTRORAZOXANE
CAS:24584-09-6
MF:C11H16N4O4
MW:268.27
EINECS:
Product Categories:API;Chelating Agent
Mol File:24584-09-6.mol
Dexrazoxane Structure
Dexrazoxane Chemical Properties
Melting point 194-196°C
alpha D +11.35° (c = 5 in DMF)
Boiling point 531.5±50.0 °C(Predicted)
density 1.333±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >20mg/mL
form powder
pka2.1(at 25℃)
color white to off-white
Merck 14,8123
InChIKeyBMKDZUISNHGIBY-ZETCQYMHSA-N
CAS DataBase Reference24584-09-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR UN 2811 6.1 / PGIII
WGK Germany 3
RTECS TL6390000
Hazardous Substances Data24584-09-6(Hazardous Substances Data)
MSDS Information
Dexrazoxane Usage And Synthesis
DescriptionDexrazoxane is the dextro-isomer of razoxane approved as a protectant against the cardiotoxicity of doxorubicin in breast cancer patients. This agent does not alter the anticancer effect of doxorubicin. Its mode of action suggests a chelation of free radicals. In mice, dexrazoxane also offers protection against cardiac side effects of epirubicin, but not mitoxantrone.
OriginatorImperial Cancer Research Fund (United Kingdom)
UsesCardioprotectant.
Brand nameZinecard (Pharmacia & Upjohn);Cardioxane.
Biological ActivityTopoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.
Veterinary Drugs and TreatmentsDexrazoxane may be useful to attenuate the cardiotoxic effects of doxorubicin in patients who are showing signs of anthracycline cardiotoxicity, have cardiac disease, or are at maximum cumulative dosages of doxorubicin. It is also used to treat extravasation injuries associated with doxorubicin.
While dexrazoxane has been shown to be cardioprotective when given at dosages of 10 times the doxorubicin dose, there is evidence that it may also partially protect the cancer cells being treated.
Dexrazoxane Preparation Products And Raw materials
Tag:Dexrazoxane(24584-09-6) Related Product Information
ICRF-186 2,2',2'',2'''-[[(1S)-1-Methyl-1,2-ethanediyl]dinitrilo]tetrakisacetamide N-(2-Amino-2-oxoethyl)-N-[(2S)-2-(3,5-dioxo-1-piperazinyl)propyl]-glycine ICRF 198 N-(2-Amino-2-oxoethyl)-N-[(1S)-2-(3,5-dioxo-1-piperazinyl)-1-methylethyl]-glycine (S)-(+)-1,2-Diaminopropane-N,N,N',N'-tetraacetic acid Glycine, N-(2-amino-2-oxoethyl)-N-[(2R)-2-(3,5-dioxo-1-piperazinyl)propyl]- Glycine, N-(2-amino-2-oxoethyl)-N-[2-(3,5-dioxo-1-piperazinyl)propyl]- 1,1'-ethylenedipiperazine Dexrazoxane Intermediate Dexrazoxane hydrochloride Dexrazoxane Chlorhydrate Parathion-methyl 4,4'-propylenebis(piperazine-2,6-dione) Methyl 2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- 4-(2-AMINO-ETHYL)-PIPERAZIN-2-ONE Piperazine-2,6-dione