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Dovitinib Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:Dovitinib
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: CAS:915769-50-5
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: career henan chemical co
Tel: +86-371-86658258
Products Intro: Product Name:Dovitinib
Purity:99% Package:1kg;2USD
Company Name: Guangzhou Isun Pharmaceutical Co., Ltd  Gold
Tel: 020-39119399 18927568969
Products Intro: Product Name:Dovitinib lactate
Purity:98% Package:25mg; 100mg; 1g; 5g; 25g;100g
Company Name: Shanghai Boyle Chemical Co., Ltd.  
Products Intro: Product Name:Dovitinib

Lastest Price from Dovitinib manufacturers

  • Dovitinib
  • US $2.00 / kg
  • 2018-12-26
  • CAS:915769-50-5
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
Dovitinib Basic information
Anticancer drugs
Product Name:Dovitinib
Synonyms:dovitinib;4-Amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone 2-hydroxypropanoate hydrate (1:1:1);Unii-69vky8p7ea;Dovitinib lactate;Dovitinib lactate(TKI258);Propanoic acid, 2-hydroxy-, coMpd. with 4-aMino-5-fluoro-3-[6-(4-Methyl-1-piperazinyl)-1H-benziMidazol-2-yl]-2(1H)-quinolinone, hydrate (1:1:1);MultidiMensional iMatinib;Dovitinib lactate(TKI-258, CHIR-258)
Product Categories:Anti-cancer&immunity;Inhibitors
Mol File:915769-50-5.mol
Dovitinib Structure
Dovitinib Chemical Properties
Safety Information
MSDS Information
Dovitinib Usage And Synthesis
Anticancer drugsDovitinib is an orally active small molecule multi-targeted tyrosine kinase inhibitor which can act directly on the tumor cells and provide nutritional support for blood vessels and stromal tumor cells, it has inhibition effect on a variety of growth factors such as VEGFR1-3, FGFR1-3, PDGFRB, e-KIT, Ret, TraA and csf-1. At present, Dovitinib is in clinical trail phase III ,clinical studies show that it has significant therapeutic effect on breast cancer, urinary tract carcinoma, prostate cancer, multiple myeloma, melanoma. With the development of clinical researches, cancer treatment is expected to expand its scope.
Dovitinib performs its anti-tumor effects by anti-angiogenic activity and anti-proliferative survival activity . The drug is used for inoperable/local treatment of advanced hepatocellular carcinoma patients,it requires the lesion diameter greater than 1cm , blood, liver function is good, physical condition is good ,patients do not receive any systemic therapy (allow surgery 4 weeks outside and radiotherapy and intervention ).
Preparation: use 5-chloro-2-nitroaniline and N-methyl piperazine as raw materials,after substitution,and reduction, form a ring with β-ethoxy-β-imino-propionate hydrochloride .Finally,after cyclization with 2-amino-6-fluorobenzonitrileto, generate Dovitinib , a total yield of 44.1%.
The above information is edited by the chemicalbook of Tian Ye.
Dovitinib Preparation Products And Raw materials
Tag:Dovitinib(915769-50-5) Related Product Information
Imatinib fluoro jade Dasatinib monohydrate Basic Violet 1 Sunitinib Methyl acetate Lapatinib Gefitinib Paraquat dichloride Kresoxim-methyl L(+)-Lactic acid Methyl Acetonitrile Methanol Benzimidazole Methyl acrylate 8-Hydroxyquinoline benzimidazolone