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Piperonyl aldehyde

Piperonyl aldehyde Basic information
Product Name:Piperonyl aldehyde
Synonyms:Tadalafil Impurity 43 (Piperonal);3,4-Bis(methylenedioxy)benzaldehyde;3,4-Dihydroxybenzaldehyde methylene ketal;3,4-dihydroxybenzaldehydemethyleneketal;3,4-dimethylenedioxybenzaldehyde;3,4-methylenedihydroxybenzaldehyde;3,4-Methylene-dihydroxybenzaldehyde;3,4-Methylenedioxybenzalbehybe
Product Categories:Food and Feed Additive;Aldehydes;Building Blocks;C8;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
Mol File:120-57-0.mol
Piperonyl aldehyde Structure
Piperonyl aldehyde Chemical Properties
Melting point 35-39 °C(lit.)
Boiling point 264 °C(lit.)
density 1.2645 (rough estimate)
vapor pressure 1 mm Hg ( 87 °C)
refractive index 1.4500 (estimate)
Fp >230 °F
storage temp. Dark Room
solubility methanol: 0.1 g/mL, clear
Water Solubility Slightly soluble
Sensitive Air & Light Sensitive
Merck 13,7556
JECFA Number896
BRN 131691
Stability:Stable, but air and light sensitive. Combustible. Incompatible with strong oxidizing agents, bases.
CAS DataBase Reference120-57-0(CAS DataBase Reference)
NIST Chemistry ReferencePiperonal(120-57-0)
EPA Substance Registry System1,3-Benzodioxole- 5-carboxaldehyde(120-57-0)
Safety Information
Hazard Codes Xi
Risk Statements 38-52/53
Safety Statements 61-24/25
WGK Germany 2
RTECS TO1575000
HS Code 29329300
Hazardous Substances Data120-57-0(Hazardous Substances Data)
ToxicityLD50 orally in rats: 2700 mg/kg (Hagan)
MSDS Information
SigmaAldrich English
ALFA English
Piperonyl aldehyde Usage And Synthesis
Chemical Propertieswhite crystalline solid
UsesPiperonal is an impurity of Tadalafil (T004500). Tadalafil impurity A.
DefinitionChEBI: An arenecarbaldehyde that is 1,3-benzodioxole substituted by a formyl substituent at position 5. It has been isolated from Piper nigrum.
UsesIn perfumery, in cherry and vanilla flavors, in organic syntheses.
General DescriptionColorless lustrous crystals.
Air & Water ReactionsSlightly water soluble .
Reactivity ProfilePiperonyl aldehyde is an aldehyde. Aldehydes are frequently involved in self-condensation or polymerization reactions. These reactions are exothermic; they are often catalyzed by acid. Aldehydes are readily oxidized to give carboxylic acids. Flammable and/or toxic gases are generated by the combination of aldehydes with azo, diazo compounds, dithiocarbamates, nitrides, and strong reducing agents. Aldehydes can react with air to give first peroxo acids, and ultimately carboxylic acids. These autoxidation reactions are activated by light, catalyzed by salts of transition metals, and are autocatalytic (catalyzed by the products of the reaction). The addition of stabilizers (antioxidants) to shipments of aldehydes retards autoxidation. Piperonyl aldehyde is sensitive to light. Piperonyl aldehyde may react with oxidizing materials.
Fire HazardFlash point data for Piperonyl aldehyde are not available. Piperonyl aldehyde is probably combustible.
Safety ProfileModerately toxic by ingestion and intraperitoneal routes. Can cause central nervous system depression. A human skin irritant. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidizing materials. See also ALDEHYDES.
Purification MethodsCrystallise piperonal from aqueous 70% EtOH or EtOH/water. [Beilstein 19/4 V 225.]
Tag:Piperonyl aldehyde(120-57-0) Related Product Information
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