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L-Serine Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718
Products Intro: Product Name:L-Serine
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
Products Intro: Product Name:L-Serine
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Taizhou Tianhong Biochemistry Technology Co., Ltd.
Tel: 0523-86132544
Products Intro: Product Name:L-Serine
Purity:99% Package:10g;100g;1Kg;25kg
Company Name: Shanghai Bojing Chemical Co.,Ltd.
Tel: +86-21-37122233
Products Intro: Product Name:L-Serine
Purity:USP24 Package:1Kg;25kg/ Drum or as customer request
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: CAS:56-45-1
Purity:99% Package:500G;1KG;5KG;25KG

Lastest Price from L-Serine manufacturers

  • L-Serine
  • US $48.00-40.00 / KG
  • 2021-10-19
  • CAS:56-45-1
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 200tons
  • L-Serine
  • US $0.00 / Kg/Drum
  • 2021-09-29
  • CAS:56-45-1
  • Min. Order: 1KG
  • Purity: 98.5%-101.5%
  • Supply Ability: 10 TONS
  • L-Serine
  • US $40.00 / KG
  • 2021-08-26
  • CAS:56-45-1
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 5000kg
L-Serine Basic information
Identification test Content analysis Toxicity Usage limitation Chemical Properties Usage Production
Product Name:L-Serine
Synonyms:(s)-2-amino-3-hydroxypropanoicacid;2-Amion-3-hydroxypropionicacid;alpha-Amino-beta-hydroxypropionic acid;alpha-amino-beta-hydroxypropionicacid;Propanoic acid, 2-amino-3-hydroxy-, (S)-;8-HYDROXY-L-ALANINE;L-(-)-SERINE;L-(+)-SERINE
Product Categories:GABA/Glycine receptor;Serine [Ser, S];Amino Acids and Derivatives;alpha-Amino Acids;Amino Acids;Biochemistry;Amino Acid Derivatives;Nutritional Supplements;L-Amino Acids;Amino Acids;amino;Amino acid
Mol File:56-45-1.mol
L-Serine Structure
L-Serine Chemical Properties
Melting point 222 °C (dec.) (lit.)
alpha 15.2 º (c=10, 2N HCl)
Boiling point 197.09°C (rough estimate)
density 1.6
refractive index 1.4368 (estimate)
Fp 150°C
storage temp. 2-8°C
solubility H2O: 50 mg/mL
form powder
pka2.19(at 25℃)
color White
PH5-6 (100g/l, H2O, 20℃)
optical activity[α]20/D +13.5±0.5°, c = 5% in 5 M HCl
Water Solubility 250 g/L (20 ºC)
λmaxλ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.05
Sublimation 150 ºC
Merck 14,8460
BRN 1721404
Stability:Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference56-45-1(CAS DataBase Reference)
NIST Chemistry ReferenceL-Serine(56-45-1)
EPA Substance Registry SystemL-Serine (56-45-1)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 24/25-36-26
WGK Germany 3
RTECS VT8100000
HS Code 29225000
Hazardous Substances Data56-45-1(Hazardous Substances Data)
MSDS Information
Ser English
SigmaAldrich English
ACROS English
ALFA English
L-Serine Usage And Synthesis
Identification test1ml ninhydrin (TS-250) was added to 5ml sample solution (0.1%) should produce red purple or violet color. 200mg Periodic acid was added to the above solution and heated. Dissolving a sample of about 500 rag in 10 ml water, adding 200 mg of Periodic acid and heating, should produce the smell of formaldehyde.
Content analysisSame as "DL-serine (01126)"
ToxicityIt can be used in food safely (FDA,§172.320,2000).
Usage limitationIt takes up to 8.4% of total protein quantity(FDA,§172.320,2000).
Chemical PropertiesSix-sided flaky crystal or prismatic crystal, soluble in water(20℃,25g/100ml water)
UsageUsed as a biochemical reagent and food additive, Used for biochemical research, the preparation of tissue culture, and used as amino acids nutrition medicine.
ProductionL-Serine can be obtained by a variety of methods. Methods common seen are as follows:
1. Obtain it though the hydrolysis of protein with a high content of L – Serine and recycled by ion exchange resin;
2. Obtain it by the reaction between ethyl formate and ethylhippurate;
3. Obtain it by using carbohydrate as the starting material through zymotechnics;
4. In alkaline condition, the raw material of  DL-serine and chloracetyl chloride reacted, then, extracted with ethyl acetate after drying by distillation, treated by active carbon, chiral separated by acylation enzyme to obtain the product;
5. Hydrolysis:
The raw material of silkworm cocoon was hydrolyzed in acid condition and separated and purified with ion exchange water. process engineering: silkworm cocoon [acid hydrolysis]→[HCl, 110℃, 24h] hydrolysate [deacidification,decoloration]→[732resin,ammonia,pH3.5-8] eluant [fractionation]→[717 resin] drips [Concentration, crystallization, and refined]→[film evaporation]→L-serine
Acid hydrolysis: Adding 30 kg silkworm cocoon to a crock, then adding 150 L HCl With a concentration of 6 mol/L, stirting heating to 110 ℃ for 24 h, after cooling below 60 ℃, filtering and washing the filter residue with pure water of five times the amount of filtrate, at five times the filtrate volume of washing, merging the  washing liquor into the filtrate to obtain 800 L of aqueous solution.
Deacidification and liquid-removal: 100L of hydrolysate flows through H + type 732 cation exchange resin column (150 mm x 2000 mm polyvinyl chloride, filled with 25L resin for each of the 2 columns) from top to bottom with a flow velocity of 100-120ml/min,
, then washed with purified water to remove pigments to obtain clear liquid without Cl-.0.3 mol/L ammonia flows through the column from top to bottom with a flow velocity of 80-100ml/min till outflow of amino acids, collecting the eluent within pH3.5-8. Finally, 1 mol/L of ammonia was used to wash Tyrosine followed by deammoniation, concentration and crystallization to obtain crude tyrosine.
The above eluent was separated with 4 regular OH-type 717 Anion exchange resin columns:
Column1 50mm×2000mm, filled with 24L resin (polyvinyl chloride)
Column2 150mm×1800mm, filled with 22L resin (polyvinyl chloride)
Column3 150mm×1600mm, filled with 20L resin (polyvinyl chloride)
Column4 150mm×1400mm, filled with 10L resin (polyvinyl chloride)
Firstly, the pH value of the eluent was adjusted to 7-8 with 1mol/L NaOH Solution. Then, the eluent was separated in the first column with the flow rate of 120-150 ml/min until the saturation of the resin and washed to neutral with pure water. Column1 and column2 were connected in series, eluted using 0.1 mol/L HCl with the flow rate of 80-100 ml/min, collected 25 reagent Bottles ((1000 ml/bottle)until the appearance of amino acid in effluent. Colunm 4 was then connected in series and the elution process was continued. About 50 reagent Bottles were collected until the appearance of amino acid in effluent and the pH value of the eluent reached 2-3.
Paper chromatography was used to purify and collect extracts containing serine.
After concentration, crystallization, and refinement, the above extraction was evaporated and concentrated until crystallization occurrence. After cooling, anhydrous ethanol which is 2 times the amount of the extraction was added, stored in a refrigerator overnight, and dried after crystal precipitation to obtain L-Serine. The yield is about 4% Calculated on cocoon.
6. Hydrolysis:
Fermentation with precursor addition
The in vivo metabolism speed of L-Serine is very fast and direct fermentation production is difficult.  Generally, the method of fermentation with precursor addition is adopted. The precursors mainly include glycine, betaine and glyceric acid, among which Fermentation with glyceric acid precursor has been industrialized. Producing strains include anaerobic type and Methylotrophs.
Heterotroph, glycine produced L-Serin
glycine [Glycine rod acid , Butane Nocardia or white sarcina]→[fermentation] L-Serine.
Methylotrophs   glycine produced L-Serin
glycine[pseudomonas, Hyphomicrobium or Methanol assimilation Arthrobacter globiformis] →[fermentation] L-Serine.
7. Chemical synthesis:
DL-Serine can be synthesized by using glycolaldehyde as raw material and
and chiral separated to obtain L-Serine.
Synthesis by using glycolaldehyde as raw material
Synthesis by using diethyl bromomalonate as raw material
Synthesis by using Vinyl compounds as raw material
8. Enzymatic method:
Chemically synthesized DL-2 Oxazolidine-4-carboxylic acid (DL-OOC)
was used as raw material to produce L – serine under the catalysis of
testosterone pseudomonas produced L-OOC hydrolase or Bacillus subtilis
produced OOC racemase.
DL-2-Oxazolidine-4-carboxylic acid (DL-OOC)[L-OOC hydrolase or racemase]→L-serine
DescriptionSerine (abbreviated as Ser or S) is an amino acid with the formula HO2CCH(NH2)CH2OH. It is one of the proteinogenic amino acids. Its codons in the genetic code are UCU, UCC, UCA, UCG, AGU and AGC. By virtue of the hydroxyl group, serine is classified as a polar amino acid.
Chemical PropertiesWhite crystalline powder
UsesAmino acid.
DefinitionChEBI: The L-enantiomer of serine.
Production MethodsIndustrially , L - serine is produced by fermentation, with an estimated 100 - 1000 tonnes per year produced . In the laboratory, racemic serine can be prepared from methyl acrylate via several steps.
Biotechnological ProductionSerine is the first amino acid produced in the 3-phosphoglycerate pathway. It is further converted to glycine and L-cysteine. Industrially L-serine can be produced by direct fermentation or by an enzymatic process from glycine. The enzymatic route developed by Mitsui reacts glycine with formaldehyde using serine hydroxymethyltransferase (SHMT). With an overexpression of SHMT in E. coli, concentrations of serine of over 300 g/L in 35 h reaction time have been reported, with a glycine conversion of[98 %. This process requires the addition of tetrahydrofolic acid to the system as a cofactor. An alternative to enzymatic production is a direct fermentation to give L-serine. Strains based on Brevibacterium flavum and C. glutamicum have been described. In both strains, the enzymes phosphoglycerate dehydrogenase (serA), phosphoserine phosphatase (serB), and phosphoserine transaminase (serC) have been overexpressed. These enzymes are involved in the biosynthesis pathway from 3-phosphoglycerate. Note that because of product inhibition by L-serine of serA, feedback-resistant mutants have been developed to increase yields. A mutant strain of B. flavum with a feedback-resistant serA* and overexpression of the serA*, serB, and serC has been reported to accumulate 35.2 g/L L-serine with a carbon yield of 32 % based on glucose. In addition it has been shown that increased yields in C. glutamicum can be obtained by deleting the L-serine degrading enzyme L-serine dehydratase (sdaA).
Biological ActivityEndogenous agonist at the inhibitory glycine receptor.
Biotechnological ApplicationsMetabolic
Serine is important in metabolism in that it participates in the biosynthesis of purines and pyrimidines. It is the precursor to several amino acids including glycine and cysteine, and tryptophan in bacteria. It is also the precursor to numerous other metabolites, including sphingolipids and folate, which is the principal donor of one-carbon fragments in biosynthesis.
Structural role
Serine plays an important role in the catalytic function of many enzymes. It has been shown to occur in the active sites of chymotrypsin, trypsin, and many other enzymes. The so-called nerve gases and many substances used in insecticides have been shown to act by combining with a residue of serine in the active site of acetylcholine esterase, inhibiting the enzyme completely.
As a constituent (residue) of proteins, its side chain can undergo O-linked glycosylation, which may be functionally related to diabetes.
It is one of three amino acid residues that are commonly phosphorylated by kinases during cell signaling in eukaryotes. Phosphorylated serine residues are often referred to as phosphoserine.
D-Serine, synthesized in the brain by serine racemase from Lserine (its enantiomer), serves as both a neuro transmitter and a gliotransmitter by coactivating NMDA receptors, making them able to open if they then also bind glutamate. D-serine is a potent agonist at the glycine site of the NMDA-type glutamate receptor. For the receptor to open, glutamate and either glycine or D-serine must bind to it. In fact, D-serine is a more potent agonist at the glycine site on the NMDAR than glycine itself. D-serine was only thought to exist in bacteria until relatively recently; it was the second D amino acid discovered to naturally exist in humans, present as a signalling molecule in the brain, soon after the discovery of D-aspartate. Had D amino acids been discovered in humans sooner, the glycine site on the NMDA receptor might instead be named the D-serine site.
Gustatory sensation
Pure D-Serine is an off-white crystalline powder with a very faint funky or dirty aroma. L-Serine is sweet with minor umami and sour tastes at high concentration. D-Serine is sweet with an additional minor sour taste at medium and high concentrations.
Chemical SynthesisThis compound is one of the naturally occurring proteinogenic amino acids. Only the L-stereoisomer appears naturally in proteins. It is not essential to the human diet, since it is synthesized in the body from other metabolites, including glycine. Serine was first obtained from silk protein, a particularly rich source, in 1865. Its name is derived from the Latin for silk, sericum. Serine's structure was established in 1902.
The biosynthesis of serine starts with the oxidation of 3- phosphoglycerate to 3-phosphohydroxypyruvate and NADH. Reductive amination of this ketone followed by hydrolysis gives serine. Serine hydroxymethyltransferase catalyzes the reversible, simultaneous conversions of L-serine to glycine (retro-aldol cleavage) and 5,6,7,8-tetra hydrofolate to 5,10-methylene tetra hydrofolate (hydrolysis).
This compound may also be naturally produced when UV light illuminates simple ices such as a combination of water, methanol, hydrogen cyanide, and ammonia, suggesting that it may be easily produced in cold regions of space.
Purification MethodsA likely impurity is glycine. Crystallise L-serine from H2O by adding 4volumes of EtOH. Dry and store it in a desiccator. It sublimes at 160-170o/0.3mm with 99.7% recovery, and unracemised [Gross & Gradsky J Am
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