Tyramine hydrochloride manufacturers
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| | Tyramine hydrochloride Basic information |
| Product Name: | Tyramine hydrochloride | | Synonyms: | fMLP (misnomer but widely used);TYRAMINE HCL(P);TYRAMINE HCL(RG);N-Formylmethionine Leucyl-Phenylalanine;Chemotactic peptide, fMLF, fMLP (misnomer but widely used), N-Formyl-L-methionyl-L-leucyl-L-phenylalanine;Formyl-L-Met-L-Leu-L-Phe-OH;N-Formyl-L-Met-L-Leu-L-Phe-OH;N-Formyl-L-methionyl-L-leucyl-L-phenylalanine
For-Met-Leu-Phe-OH | | CAS: | 59880-97-6 | | MF: | C21H31N3O5S | | MW: | 437.55 | | EINECS: | 200-462-5 | | Product Categories: | | | Mol File: | 59880-97-6.mol |  |
| | Tyramine hydrochloride Chemical Properties |
| Melting point | 271-274 °C(lit.) | | Boiling point | 269 °C | | density | 1.198±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMF: 50 mg/mL, clear, colorless | | pka | 3.50±0.10(Predicted) | | form | White to off-white lyophilized solid | | color | White to Almost white | | BRN | 2315783 | | Sequence | N-Formyl-Met-Leu-Phe-OH | | Major Application | cell analysis | | InChIKey | PRQROPMIIGLWRP-BZSNNMDCSA-N | | SMILES | C(O)(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC=O | | CAS DataBase Reference | 59880-97-6(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-22 | | WGK Germany | 3 | | RTECS | SJ6050000 | | F | 3-10 | | HS Code | 2930.90.9250 | | Storage Class | 11 - Combustible Solids |
| | Tyramine hydrochloride Usage And Synthesis |
| Uses | Induces leucocyte chemotaxis, and activates macrophages | | Uses | N-Formyl-Met-Leu-Phe has been used for:
- creating gradients in Zigmond chamber chemotaxis assay performed on neutrophils
- use in neutrophil chemotaix assay and
- determination of the involvement of MAPK-activating protein kinase-2 (MAPKAPK-2) and/or p38, in the signaling pathway of human polymorphonuclear leukocytes (PMNs) stimulated by N-Formyl-Met-Leu-Phe.
| | Definition | ChEBI: A tripeptide composed of L-Met, L-Leu and L-Phe in a linear sequence with a formyl group at the amino terminus. It acts as a potent inducer of leucocyte chemotaxis and macrophage activator as well as a ligand for the FPR receptor. | | General Description | N-Formyl-Met-Leu-Phe is a chemotactin peptide, which functions on polymorphonuclear leukocytes (PMN), neutrophils etc. | | Biochem/physiol Actions | Potent chemotactic peptide. Induces a metabolic burst in macrophages accompanied by an increase in respiratory rate, secretion of lysosomal enzymes, and production of superoxide anion. | | storage | Store at -20°C |
| | Tyramine hydrochloride Preparation Products And Raw materials |
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