- Pilsicainide
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- $1520.00 / 25mg
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2025-04-27
- CAS:88069-67-4
- Min. Order:
- Purity:
- Supply Ability: 10g
- Pilsicainide
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- $1.00 / 1g
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2025-01-03
- CAS:88069-67-4
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 50tons
- PILSICAINIDE
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- $1.00 / 1KG
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2020-02-20
- CAS:88069-67-4
- Min. Order: 1KG
- Purity: 98%HPLC
- Supply Ability: 10Tons
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| | PILSICAINIDE Basic information |
| Product Name: | PILSICAINIDE | | Synonyms: | PILSICAINIDE;PILSICAININIDE;PILSICAINIDE(FORRESEARCHONLY);N-(2，6-Dimethylphenyl)tetrahydro-1H-pyrrolizine-7α(5H)-acetamide;SUN-1165;Sunrhythm;N-(2,6-Dimethylphenyl)-2,3,6,7-tetrahydro-1H-pyrrolizine-7a(5H)-acetamide;N-(2,6-Dimethylphenyl)tetrahydro-1H-pyrrolizine-7a(5H)-acetamide | | CAS: | 88069-67-4 | | MF: | C17H24N2O | | MW: | 272.39 | | EINECS: | | | Product Categories: | | | Mol File: | 88069-67-4.mol |  |
| | PILSICAINIDE Chemical Properties |
| storage temp. | Sealed in dry,2-8°C |
| Hazard Codes | Xn | | Risk Statements | 22 |
| | PILSICAINIDE Usage And Synthesis |
| Chemical Properties | Pilsicainide: C17H24N2O?HCl?1/2H20. [88069-49-2]. It is obtained from the crystallization of ethanol-diethyl ether. Odorless, bitter taste, melting point 212 ~ 214℃. It is highly soluble in glacial acetic acid and soluble in methanol, ethanol or water. | | Uses | Pilsicainide is a class IC antiarrhythmic drug, suitable for the treatment of patients with ventricular tachycardia ineffective or intolerable to other antiarrhythmic drugs. | | Definition | ChEBI: Pilsicainide is a secondary carboxamide resulting from the formal condensation of the amino group of 2,6-dimethylaniline with the carboxy group of (tetrahydro-1H-pyrrolizin-7a(5H)-yl)acetic acid. It is a sodium channel blocker which is used as an antiarrhythmic drug for the management of atrial tachyarrhythmias in Japan. It has a role as an anti-arrhythmia drug and a sodium channel blocker. It is a secondary carboxamide and an organic heterobicyclic compound. | | Synthesis | Pilsicainide was obtained from tetrahydrodithickened pyrrole ethyl acetate and 2, 6-dimethylaniline heated and condensed in dioxane at 100℃ under the action of sodium hydride. It is also possible to hydrolyze tetrahydrodithickened pyrrole ethyl acetate and chlorinate it to tetrahydrodithickened pyrrole acetyl chloride, which is then condensed with 2, 6-dimethylaniline. | | in vivo | Pilsicainide (SUN 1165 free acid; 2 mg/kg; i.v.; once) decreases the conduction velocity in T4-treated rat atrium by decreasing the Max dV/dt and net inward current[1]. | Animal Model: | Male Sprague-Dawley (SD) rats weighing from 200 to 220 g, with levo-thyroxine (T4) treatment[1] | | Dosage: | 2 mg/kg | | Administration: | Bolus injection into right external carotid vein within 2 minutes, once | | Result: | Elongated the QT interval at 15 and 60 minutes after administration.
Shortened P wave and QRS complex durations.
Markedly decreased action potential amplitudes (APA) and Max dV/dt, and significantly lengthened the action potential durations.
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| | PILSICAINIDE Preparation Products And Raw materials |
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