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Levothyroxine sodium

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Products Intro: Product Name:Sodium (S)-2-amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate pentahydrate
CAS:55-03-8
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
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CAS:55-03-8
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Products Intro: Product Name:levothyroxine sodium
CAS:55-03-8
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CAS:55-03-8
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Levothyroxine sodium manufacturers

  • Levothyroxine sodium
  • $3095.00 / Kg/Bag
  • 2021-11-30
  • CAS:55-03-8
  • Min. Order: 1KG
  • Purity: 99
  • Supply Ability: 1T
  • Levothyroxine sodium
  • $0.00 / Kg/Bag
  • 2021-09-29
  • CAS:55-03-8
  • Min. Order: 100g
  • Purity: 97%-103% HPLC
  • Supply Ability: 10KGS
  • Levothyroxine sodium
  • $10.00 / KG
  • 2021-08-31
  • CAS:55-03-8
  • Min. Order: 25Kg/Drum
  • Purity: 99.99%
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Levothyroxine sodium Basic information
Product Name:Levothyroxine sodium
Synonyms:Levothyroxine sodium;Sodium 4-O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine;(S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionic Acid odium;(s)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionic acid sodium salt;sodium (s)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionate;L-THYROXINE SODIUM ANHYDROUS;Levothyroxine Sdium;levothyroxine sodium anhydrous
CAS:55-03-8
MF:C15H12I4NNaO4
MW:800.87
EINECS:200-221-4
Product Categories:Amino Acids & Derivatives;Aromatics;Medicine intermediate;Amino Acids;Biochemistry;Biological-modified Amino Acids;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone
Mol File:55-03-8.mol
Levothyroxine sodium Structure
Levothyroxine sodium Chemical Properties
Melting point 207-210 (dec.)(lit.)
alpha D20 -4.4° (c = 3 in 70% ethanol)
density d420 2.381
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility cell culture medium: 0.1 mg/mL
form powder
InChIKeyJMHCCAYJTTWMCX-QWPJCUCISA-M
EPA Substance Registry SystemLevothyroxine sodium (55-03-8)
Safety Information
Safety Statements 22-24/25
RIDADR 2811
WGK Germany 3
RTECS YP2833760
3-8-10
HazardClass 6.1(a)
PackingGroup II
HS Code 2937909000
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
Levothyroxine sodium Usage And Synthesis
Chemical PropertiesLevothyroxine sodium  is White Solid
OriginatorSynthroid,Flint,US,1953
UsesOne of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.
DefinitionChEBI: The sodium salt of L-thyoxine. It is used as replacement therapy in the treatment of hypothyroidism.
IndicationsLevothyroxine sodium (Levothroid, Synthroid, Levoxine) is the sodium salt of the naturally occurring levorotatory isomer of T4. It is the preparation of choice for maintenance of plasma T4 and T3 concentrations for thyroid hormone replacement therapy in hypothyroid patients. It is absorbed intact from the gastrointestinal tract, and its long half-life allows for convenient oncedaily administration. Since much of the T4 is deiodinated to T3, it is usually unnecessary to use more expensive preparations containing both T4 and T3.The aim is to establish euthyroidism with measured serum concentrations of T4, T3, and TSH within the normal range.
The TSH-suppressive effects of exogenous T4 also prove useful in removing the stimulatory effects of TSH on the thyroid gland in the management of simple nonendemic goiter, chronic thyroiditis, and TSHdependent thyroid carcinoma.
Manufacturing ProcessA 9.30 g portion of N-acetyl-L-diiodotyrosinamide was suspended in 100 ml of 0.05M boric acid (H3BO3) and 100 ml of 95% ethanol, and the solid was dissolved by adjusting the pH to 10.5 with 2N sodium hydroxide (NaOH). A 15% (by weight) portion of manganese sulfate monohydrate was added and the solution heated at 44°C under conditions of oxygenation while being agitated mechanically. After approximately 24 hours of incubation, the precipitated product was collected and separated from the catalyst, providing the amide of N-acetyl-L-thyroxine in 30.6% yield. On hydrolysis (removal of both amide functions), achieved by refluxing in glacial acetic acid-hydrochloric acid (approximately 2:1), L-thyroxine is obtained. It was isolated as the sodium salt, containing approximately 5 molecules of water of hydration.
Brand nameLevo-T (Alara); Levolet (Vintage); Levothroid (Lloyd); Levoxyl (Jones); Novothyrox (Genpharm); Synthroid (Abbott); Unithroid (Stevens J).
Therapeutic FunctionThyroid hormone
General DescriptionLevothyroxine sodium,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-2-tyrosinemonosodium salt, hydrate (Synthroid, Letter, Levoxine,Levoid), is the sodium salt of the levo isomer of thyroxine,which is an active physiological principle obtained from thethyroid gland of domesticated animals used for food by humans.It is also prepared synthetically. The salt is a light yellow,tasteless, odorless powder. It is hygroscopic but stablein dry air at room temperature. It is soluble in alkali hydroxides,1:275 in alcohol, and 1:500 in water, to give a pH ofabout 8.9.
Clinical UseLiothyronine sodium occurs in vivo together withlevothyroxine sodium; it has the same qualitative activitiesas thyroxine but is more active. It is absorbed readily fromthe gastrointestinal tract, is cleared rapidly from the bloodstream,and is bound more loosely to plasma proteins than isthyroxine, probably because of the less acidic phenolic hydroxylgroup.Its uses are the same as those of levothyroxine sodium,including treatment of metabolic insufficiency, male infertility,and certain gynecological disorders.
Veterinary Drugs and TreatmentsLevothyroxine sodium is indicated for the treatment of hypothyroidism in all species.
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