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10-Hydroxycamptothecin

10-Hydroxycamptothecin Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: 571-85586718 +8613336195806
Email: sales@capotchem.com
Products Intro: Product Name:10-Hydroxycamptothecine
CAS:19685-09-7
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
Email: info@dakenchem.com
Products Intro: Product Name:10-Hydroxycamptothecin
CAS:19685-09-7
Purity:99% Package:100g ,1KG ,5KG 25KG
Company Name: Shanghai Bojing Chemical Co.,Ltd.
Tel: +86-21-37122233 +86-13795318958
Email: Candy@bj-chem.com
Products Intro: Product Name:10-Hydroxycamptothecin
CAS:19685-09-7
Purity:99% Package:1kg;25kg;200kg Cardboard barrels Remarks:White powder
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070
Email: product@chemlin.com.cn
Products Intro: CAS:19685-09-7
Purity:98% Package:g-Kg Remarks:Yellow powder
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Email: zheyansh@163.com
Products Intro: Product Name:10-Hydroxycamptothecin
CAS:19685-09-7
Purity:HPLC>=98% Package:20mg

10-Hydroxycamptothecin manufacturers

  • 10-Hydroxycamptothecin
  • $2.50 / 1g
  • 2021-11-15
  • CAS:19685-09-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 5ton/Month
10-Hydroxycamptothecin Basic information
Product Name:10-Hydroxycamptothecin
Synonyms:Camptothecae Acuminatae extract;hydrate,(s)-dihydroxy;hydroxy-camptotheci;Hydroxycamptothencine;(20S)-10-HYDROXYCAMPTOTHECIN 98%;(20S)-10-Hydroxycamptothecin;HYDROCAMPTOTHECINE;CAMPTOTHECIN, 10-HYDROXY(SH)
CAS:19685-09-7
MF:C20H16N2O5
MW:364.35
EINECS:805-668-4
Product Categories:Inhibitors;natural product;Alkaloids;INTERMEDIATESOFIRINOTECANHCLTRIHYDRATE;Camptothecin series;Natural Plant Extract;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Natural Anti-cancer Medical Materials and It's Derivatives
Mol File:19685-09-7.mol
10-Hydroxycamptothecin Structure
10-Hydroxycamptothecin Chemical Properties
Melting point 265-270°C
Boiling point 820.7±65.0 °C(Predicted)
density 1.60
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka8.93±0.40(Predicted)
InChIKeyHAWSQZCWOQZXHI-FQEVSTJZSA-N
CAS DataBase Reference19685-09-7(CAS DataBase Reference)
Safety Information
Safety Statements 24/25
HS Code 29349990
MSDS Information
10-Hydroxycamptothecin Usage And Synthesis
DescriptionDNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways. (S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM). In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G2/M phase.
Chemical PropertiesYellow Solid
UsesA Camptothecin derivative; a topoisomerase inhibitor for cancer therapy
in vitro10-Hydroxycamptothecin inhibited the growth of BT-20 and MDA-231 cells with IC50 of 34.3nM and 7.27nM, respectively, which was more potent than camptothecin (CPT) with IC50>500nM. 10-Hydroxycamptothecin potently induces the formation of the pBR322 plasmid DNA cleavage complex mediated by human topoisomerase I with an EC50 of 0.35 μM, more than 50-fold more potent than CPT with an EC50 of 18.85 μM. 10-Hydroxycamptothecin treatment caused dose-dependent growth inhibition of human microvascular endothelial cells (HMECs) with IC50 of 0.31 μM and significantly inhibited HMEC migration with IC50 of 0.63 μM. Treatment of HMEC cells with 10-Hydroxycamptothecin also inhibited microtubule formation in a dose-dependent manner with IC50 of 0.96 μM. 10-Hydroxycamptothecin (5-20 nM) significantly inhibits the differentiation of Colo205 cells, arrests the cell cycle in G2 phase, and induces apoptosis through a caspase-3-dependent pathway.
in vivoIn the CAM model, 10-Hydroxycamptothecin treatment inhibited angiogenesis in a concentration-dependent manner, with 95% inhibition at 25 nM, more potent than suramin, which inhibited only 60% of angiogenesis at 125 nM. 10-Hydroxycamptothecin, administered orally at low doses of 2.5-7.5 mg/kg every two days, caused significant growth inhibition in Colo205 xenograft mice, but no acute toxicity. LD50: 104 mg/kg in mice (intraperitoneal injection).
10-Hydroxycamptothecin Preparation Products And Raw materials
Tag:10-Hydroxycamptothecin(19685-09-7) Related Product Information
sodium:(2S)-2-[12-ethyl-8-(hydroxymethyl)-9-oxo-2-(4-piperidin-1-ylpiperidine-1-carbonyl)oxy-11H-indolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoate Irinotecan 7,11-Diethyl-10-hydroxycaMptothecin Irinotecan Impurity 6 Irinotecan EP Impurity H 12-Hydroxy Irinotecan 7-Ethylcamptothecin Irinotecan EP Impurity K (Mixture of Diastereomers) Irinotecan IMpurity G Irinotecan Impurity 5 RPR 121056 GURKHSYORGJETM-MGDILKBHSA-N 12-ethyl-8-methyl-9-oxo-7-propionyl-9,11-dihydroindolizino[1,2-b]quinolin-2-yl [1,4'-bipiperidine]-1'-carboxylate Irinotecan Impurity 26 11-Desethyl Irinotecan Irinotecan Impurity 3 Irinotecan Hydroxyl Acid Irinotecan Impurity 2