- Flumethasone Pivalate
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- $0.00 / 1kg
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2024-04-25
- CAS:2002-29-1
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20tons
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| | Flumethasone 21-pivalate Basic information |
| Product Name: | Flumethasone 21-pivalate | | Synonyms: | 21-pivalate;locacorten;flumethasone 21-pivalate;FLUMETHASONE PIVALATE;6a,9a-difluoro-16a-methyl-prednisolone-21-pivalate;6ALPHA,9-DIFLUORO-11BETA,17,21-TRIHYDROXY-16ALPHA-METHYLPREGNA-1,4-DIENE-3,20-DIONE 21-[2,2-DIMETHYLPROPIONATE];Pregna-1,4-diene-3,20-dione, 21-(2,2-dimethyl-1-oxopropoxy)-6,9-difluoro-11,17-dihydroxy-16-methyl-, (6.alpha.,11.beta.,16.alpha.)-;6α,9-difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(2,2-dimethylpropionate) | | CAS: | 2002-29-1 | | MF: | C27H36F2O6 | | MW: | 494.57 | | EINECS: | 217-901-1 | | Product Categories: | Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Organics | | Mol File: | 2002-29-1.mol |  |
| | Flumethasone 21-pivalate Chemical Properties |
| Melting point | >263°C (dec.) | | Boiling point | 600.3±55.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | dioxane: soluble4.0ML, clear, colorless to very faintly yellow (50 mg + 4.0 mL dioxane) | | form | solid | | pka | 11.86±0.70(Predicted) | | color | White to Off-White | | optical activity | [α]25/D 71.0 to 82.0°, c = 1 in dioxane | | CAS DataBase Reference | 2002-29-1(CAS DataBase Reference) | | EPA Substance Registry System | Flumethasone-21-pivalate (2002-29-1) |
| Hazard Codes | Xn | | Risk Statements | 40 | | Safety Statements | 22-36 | | WGK Germany | 3 | | RTECS | TU3832010 | | HS Code | 2937220000 | | Toxicity | mouse,LD50,oral,> 5gm/kg (5000mg/kg),Drugs in Japan Vol. 6, Pg. 705, 1982. |
| | Flumethasone 21-pivalate Usage And Synthesis |
| Chemical Properties | White or almost white, crystalline powder. | | Uses | An anti-inflammatory anti-itching corticosteroid found in topical creams. | | Uses | flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a pivalate, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching. | | Definition | ChEBI: Flumethasone pivalate is a pivalate ester, a glucocorticoid, an 11beta-hydroxy steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It has a role as an anti-inflammatory drug and an antipruritic drug. It is functionally related to a flumethasone. | | Brand name | Locorten (Novartis). |
| | Flumethasone 21-pivalate Preparation Products And Raw materials |
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