- 9-fluoroprednisolone
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- $20.00/ kg
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2024-04-25
- CAS:338-95-4
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 20
- 9-fluoroprednisolone
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- $9.00/ g
-
2024-04-25
- CAS:338-95-4
- Min. Order: 10g
- Purity: 99%
- Supply Ability: 10 tons
- Isoflupredone USP/EP/BP
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- $1.10 / 1g
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2021-06-05
- CAS:338-95-4
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons Min
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| | Isoflupredone Basic information |
| Product Name: | Isoflupredone | | Synonyms: | ISOFLUPREDONE;DELTAFLUDROCORTISONE;9-Fluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione;Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11b)-;Pregna-1,4-diene-3,20-dione, 9-fluoro-11b,17,21-trihydroxy-;1,4-PREGNADIEN-9ALPHA-FLUORO-11BETA,17ALPHA,21-TRIOL-3,20-DIONE;1,4-PREGNADIEN-9-ALPHA-FLUORO-11-BETA, 17,21-TRIOL-3,20-DIONE;9-ALPHA-FLUOROPREDNISOLONE | | CAS: | 338-95-4 | | MF: | C21H27FO5 | | MW: | 378.43 | | EINECS: | 206-422-3 | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Steroids | | Mol File: | 338-95-4.mol |  |
| | Isoflupredone Chemical Properties |
| Melting point | 260-262°C (dec.) | | alpha | D23 +108° (c = 0.611 in ethanol); D23 +94° (alcohol)(Fried) | | Boiling point | 566.7±50.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | DMSO (Slightly), Ethanol (Slightly, Heated, Sonicated), Ethyl Acetate (Slightly) | | form | Solid | | pka | 12.10±0.70(Predicted) | | color | White to Pale Brown | | InChIKey | WAIJIHDWAKJCBX-MPVZUUJONA-N | | SMILES | [C@@]12([H])CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)CO |&1:0,10,12,14,17,19,22,r| |
| | Isoflupredone Usage And Synthesis |
| Description | Isoflupredone, also known as deltafludrocortisone and 9α-fluoroprednisolone, is a synthetic glucocorticoid corticosteroid which was never marketed. Its acetate ester is isoflupredone acetate whch is widely used in veterinary medicine[1]. | | Chemical Properties | White Solid | | Originator | Isoflupredon,Farmabios | | Uses | Isoflupredone is an anti-inflammatory. Isoflupredone could be used as an internal standard in the determination of 12 glucocorticoids in bovine milk through liquid chromatography with tandem mass spectrometry[1]. It could be used to treat endometritis by increasing pregnancy rates[2]. Isoflupredone acetate is one of four Food and Drug Administration approved corticosteroids for intra-articular use in horses[3]. | | Definition | ChEBI: 9-Fluoroprednisolone is a 21-hydroxy steroid. | | Manufacturing Process | A 100 ml broth culture containing a 0.1% yeast extract concentration, 9.0 ml
of 0.2 M KH2PO4 and 9.0 ml of 0.2 M Na2HPO4 contained in a 300 ml
Erlenmeyer flask, is seeded with 1 ml of a 24-h broth culture of
Corynehacierium simplex (A. T, C. C. 6946). The flask is incubated at 28°C for
24 h. A second 300 ml Erlenmeyer flask containing 150 mg of sterile 9α-
fluoro-4-pregnen-11β,17α,21-triol-3,20-diene in 5.0 ml acetone is inoculated
with the 24 h culture of Corynebacterium simplex (A. T. C. C. 6946). The
culture-containing steroid solution is incubated for 48 h at 28° to 30°C.
The product is extracted with chloroform and isolated by evaporation to
dryness. Recrytstallizstion of the residue affords 9α-fluoro-δ1,4-pregnadiene-
11β,17α,21-triol-3.20-dione as a solid. | | Therapeutic Function | Glucocorticoid | | References | [1] Ma L, et al. Multiresidue analysis of glucocorticoids in milk by LC-MS/MS with low-temperature purification and dispersive solid-phase extraction. Journal of Separation Science, 2017; 40: 2759-2768.
[2] Wolf C, et al. Uterine nitric oxide levels and isofluopredone treatment effect in mares susceptible to persistent post-breeding endometritis. Animal Reproduction, 2016; 13: 100-104.
[3] Knych H, et al. Expression of inflammatory and structural matrix genes in synovial fluid following intra-articular administration of isoflupredone acetate to exercised horses. Equine Veterinary Journal, 2017; 50: 504-512. |
| | Isoflupredone Preparation Products And Raw materials |
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