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4-Methoxyphenylacetic acid

4-Methoxyphenylacetic acid Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718 +86(0)13336195806
Products Intro: Product Name:2-(4-methoxyphenyl)acetic acid
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
Products Intro: Product Name:4-Methoxyphenylacetic acid
Purity:99% Package:100g ,1KG ,5KG 25KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: CAS:104-01-8
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Shanghai Time Chemicals CO., Ltd.
Tel: +86-021-57951555 +8618017249410
Products Intro: CAS:104-01-8
Company Name: career henan chemical co
Tel: +86-0371-55982848
Products Intro: Product Name:4-Methoxyphenylacetic acid
Purity:as customer's need Package:1kg;1USD

4-Methoxyphenylacetic acid manufacturers

  • 4-Methoxyphenylacetic acid
  • $15.00-10.00 / KG
  • 2021-07-13
  • CAS:104-01-8
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • 4-Methoxyphenylacetic acid
  • $15.00-10.00 / KG
  • 2021-07-10
  • CAS:104-01-8
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
4-Methoxyphenylacetic acid Basic information
Uses Description Reference
Product Name:4-Methoxyphenylacetic acid
Product Categories:Building Blocks;C9;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks;Aromatic Phenylacetic Acids and Derivatives;pharmacetical;Pyridines
Mol File:104-01-8.mol
4-Methoxyphenylacetic acid Structure
4-Methoxyphenylacetic acid Chemical Properties
Melting point 84-86 °C(lit.)
Boiling point 140 °C3 mm Hg(lit.)
density 1.1708 (rough estimate)
refractive index 1.5101 (estimate)
Fp 193°C
storage temp. Store below +30°C.
solubility 6g/l
form Crystalline Powder and Chunks
pkapK1:4.358 (25°C)
color White to light yellow
Water Solubility 6 g/L (20 ºC)
BRN 1101737
CAS DataBase Reference104-01-8(CAS DataBase Reference)
NIST Chemistry ReferenceBenzeneacetic acid, 4-methoxy-(104-01-8)
EPA Substance Registry SystemBenzeneacetic acid, 4-methoxy- (104-01-8)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38-20/21/22
Safety Statements 26-36
WGK Germany 3
RTECS AI8960000
Hazard Note Irritant
HS Code 29189090
MSDS Information
4-Methoxyphenylacetic acid English
SigmaAldrich English
ACROS English
ALFA English
4-Methoxyphenylacetic acid Usage And Synthesis
Uses4-Methoxyphenylacetic Acid is a compound that was found from microbial phenolic metabolites in human feces after the consumption of gin, red wine and dealcholized red wine.
Description4-METHOXYPHENYLACETIC ACID(104-01-8) is used in organic synthesis as well as pharmaceutical industry, especially used as an intermediate of puerarin. It can also be used as potential plasma biomarkers for early detection of non-small cell lung cancer. It is also used in drug industry as an intermediate to make Dextromethorphan.
ReferenceChen, Yan Ping, Y. M. Chen, and M. Tang. "Solubilities of cinnamic acid, phenoxyacetic acid and 4-methoxyphenylacetic acid in supercritical carbon dioxide." Fluid Phase Equilibria 275.1(2008):33-38.
Chemical Propertieswhite to light yellow crystalline powder and

Preparation of pharmaceuticals, other organic compounds.

Uses4-Methoxyphenylacetic Acid is a compound that was found from microbial phenolic metabolites in human feces after the consumption of gin, red wine and dealcholized red wine.
DefinitionChEBI: A monocarboxylic acid that is phenylacetic acid carrying a 4-methoxy substituent. It is used as an intermediate for pharmaceuticals and other organic synthesis. It has been found to inhibit the germination of cress and lettuce seeds.
Synthesis Reference(s)The Journal of Organic Chemistry, 51, p. 4354, 1986 DOI: 10.1021/jo00373a005
Tetrahedron Letters, 35, p. 133, 1994 DOI: 10.1016/0040-4039(94)88182-0
General DescriptionPale yellow or off white colored flakes. Severely irritates skin and eyes. May be toxic by ingestion.
Reactivity ProfileCarboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in 4-Methoxyphenylacetic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.
Health HazardTOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire HazardNon-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Safety ProfileModerately toxic by ingestion and intraperitoneal routes. Questionable carcinogen with experimental neoplastigenic data. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification MethodsCrystallise the acid from EtOH/water, EtOAc/pet ether (m 87o) or *C6H6/pet ether (m 84-86o). [Beilstein 10 III 431, 10 IV 544.] The acid chloride [4693-91-8] has M 184.6, b 143o/10mm, d 254
Tag:4-Methoxyphenylacetic acid(104-01-8) Related Product Information
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